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Murcko scaffold

2-[4-(Pyridin-2-yl)piperazine-1-carbonyl]-1H-indole scaffold

53 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
23
Chemicals
53
With full pages
10
Scaffold SMILES

O=C(c1cc2ccccc2[nH]1)N1CCN(c2ccccn2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2-[4-(Pyridin-2-yl)piperazine-1-carbonyl]-1H-indole page
Murcko scaffold O=C(c1cc2ccccc2[nH]1)N1CCN(c2ccccn2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 53 chemicals

Delavirdine chemical structure, C22H28N6O3S, CAS 136817-59-9
Delavirdine
CAS 136817-59-9C22H28N6O3S
Atevirdine mesylate chemical structure, C22H29N5O5S, CAS 138540-32-6
Atevirdine mesylate
CAS 138540-32-6C22H29N5O5S
Atevirdine chemical structure, C21H25N5O2, CAS 136816-75-6
Atevirdine
CAS 136816-75-6C21H25N5O2
Methanesulfonic acid--N-[2-(4-{4-[(propan-2-yl)amino]pyridin-2-yl}piperazine-1-carbonyl)-1H-indol-5-yl]methanesulfonamide (1/1) chemical structure, C23H32N6O6S2, CAS 148692-47-1
Methanesulfonic acid--N-[2-(4-{4-[(propan-2-yl)amino]pyridin-2-yl}piperazine-1-carbonyl)-1H-indol-5-yl]methanesulfonamide (1/1)
CAS 148692-47-1C23H32N6O6S2
Delavuridine chemical structure, C21H25N5O, CAS 136816-76-7
Delavuridine
CAS 136816-76-7C21H25N5O
N-Desethylatevirdine chemical structure, C19H21N5O2, CAS 160360-41-8
N-Desethylatevirdine
CAS 160360-41-8C19H21N5O2
Delavirdine mesylate chemical structure, C23H32N6O6S2, CAS 147221-93-0
Delavirdine mesylate
CAS 147221-93-0C23H32N6O6S2
Piperazine, 1-(3-(ethylamino)-2-pyridinyl)-4-(1H-indol-2-ylcarbonyl)- chemical structure, C20H23N5O, CAS 136816-72-3
Piperazine, 1-(3-(ethylamino)-2-pyridinyl)-4-(1H-indol-2-ylcarbonyl)-
CAS 136816-72-3C20H23N5O
Piperazine, 1-((5-fluoro-1H-indol-2-yl)carbonyl)-4-(3-((1-methylethyl)amino)-2-pyridinyl)- chemical structure, C21H24FN5O, CAS 136816-84-7
Piperazine, 1-((5-fluoro-1H-indol-2-yl)carbonyl)-4-(3-((1-methylethyl)amino)-2-pyridinyl)-
CAS 136816-84-7C21H24FN5O
Piperazine, 1-(3-((1-methylethyl)amino)-2-pyridinyl)-4-((3-methyl-1H-indol-2-yl)carbonyl)- chemical structure, C22H27N5O, CAS 136817-30-6
Piperazine, 1-(3-((1-methylethyl)amino)-2-pyridinyl)-4-((3-methyl-1H-indol-2-yl)carbonyl)-
CAS 136817-30-6C22H27N5O
Piperazine, 1-((4-methoxy-1H-indol-2-yl)carbonyl)-4-(3-((1-methylethyl)amino)-2-pyridinyl)- chemical structure, C22H27N5O2, CAS 138863-11-3
Piperazine, 1-((4-methoxy-1H-indol-2-yl)carbonyl)-4-(3-((1-methylethyl)amino)-2-pyridinyl)-
CAS 138863-11-3C22H27N5O2
Piperazine, 1-(3-((1-methylethyl)amino)-2-pyridinyl)-4-((4-methyl-1H-indol-2-yl)carbonyl)- chemical structure, C22H27N5O, CAS 136817-51-1
Piperazine, 1-(3-((1-methylethyl)amino)-2-pyridinyl)-4-((4-methyl-1H-indol-2-yl)carbonyl)-
CAS 136817-51-1C22H27N5O
Piperazine, 1-((5-hydroxy-1H-indol-2-yl)carbonyl)-4-(3-((1-methylethyl)amino)-2-pyridinyl)- chemical structure, C21H25N5O2, CAS 136816-97-2
Piperazine, 1-((5-hydroxy-1H-indol-2-yl)carbonyl)-4-(3-((1-methylethyl)amino)-2-pyridinyl)-
CAS 136816-97-2C21H25N5O2
Piperazine, 1-(3-((1-methylethyl)amino)-2-pyridinyl)-4-((5-methyl-1H-indol-2-yl)carbonyl)- chemical structure, C22H27N5O, CAS 136817-43-1
Piperazine, 1-(3-((1-methylethyl)amino)-2-pyridinyl)-4-((5-methyl-1H-indol-2-yl)carbonyl)-
CAS 136817-43-1C22H27N5O
Piperazine, 1-((5-amino-1H-indol-2-yl)carbonyl)-4-(3-((1-methylethyl)amino)-2-pyridinyl)- chemical structure, C21H26N6O, CAS 136817-55-5
Piperazine, 1-((5-amino-1H-indol-2-yl)carbonyl)-4-(3-((1-methylethyl)amino)-2-pyridinyl)-
CAS 136817-55-5C21H26N6O
Acetamide, N-(2-((4-(3-((1-methylethyl)amino)-2-pyridinyl)-1-piperazinyl)carbonyl)-1H-indol-5-yl)- chemical structure, C23H28N6O2, CAS 136817-58-8
Acetamide, N-(2-((4-(3-((1-methylethyl)amino)-2-pyridinyl)-1-piperazinyl)carbonyl)-1H-indol-5-yl)-
CAS 136817-58-8C23H28N6O2
Piperazine, 1-((6-methoxy-1H-indol-2-yl)carbonyl)-4-(3-((1-methylethyl)amino)-2-pyridinyl)- chemical structure, C22H27N5O2, CAS 136817-42-0
Piperazine, 1-((6-methoxy-1H-indol-2-yl)carbonyl)-4-(3-((1-methylethyl)amino)-2-pyridinyl)-
CAS 136817-42-0C22H27N5O2
Piperazine, 1-((6-fluoro-1H-indol-2-yl)carbonyl)-4-(3-((1-methylethyl)amino)-2-pyridinyl)- chemical structure, C21H24FN5O, CAS 136817-84-0
Piperazine, 1-((6-fluoro-1H-indol-2-yl)carbonyl)-4-(3-((1-methylethyl)amino)-2-pyridinyl)-
CAS 136817-84-0C21H24FN5O
1-(Indolyl-2-carbonyl)-4-(3-nitro-2-pyridyl)piperazine chemical structure, C18H17N5O3, CAS 136816-99-4
1-(Indolyl-2-carbonyl)-4-(3-nitro-2-pyridyl)piperazine
CAS 136816-99-4C18H17N5O3
Piperazine, 1-(3-amino-2-pyridinyl)-4-(1H-indol-2-ylcarbonyl)- chemical structure, C18H19N5O, CAS 136818-09-2
Piperazine, 1-(3-amino-2-pyridinyl)-4-(1H-indol-2-ylcarbonyl)-
CAS 136818-09-2C18H19N5O
Acetamide, N-(2-(4-(1H-indol-2-ylcarbonyl)-1-piperazinyl)-3-pyridinyl)- chemical structure, C20H21N5O2, CAS 153473-53-1
Acetamide, N-(2-(4-(1H-indol-2-ylcarbonyl)-1-piperazinyl)-3-pyridinyl)-
CAS 153473-53-1C20H21N5O2
Acetamide, N-ethyl-N-(2-(4-(1H-indol-2-ylcarbonyl)-1-piperazinyl)-3-pyridinyl)- chemical structure, C22H25N5O2, CAS 153473-54-2
Acetamide, N-ethyl-N-(2-(4-(1H-indol-2-ylcarbonyl)-1-piperazinyl)-3-pyridinyl)-
CAS 153473-54-2C22H25N5O2
Piperazine, 1-(3-((1,1-dimethylethyl)amino)-2-pyridinyl)-4-(1H-indol-2-ylcarbonyl)- chemical structure, C22H27N5O, CAS 136817-01-1
Piperazine, 1-(3-((1,1-dimethylethyl)amino)-2-pyridinyl)-4-(1H-indol-2-ylcarbonyl)-
CAS 136817-01-1C22H27N5O
Piperazine, 1-(1H-indol-2-ylcarbonyl)-4-(3-((1-methylpropyl)amino)-2-pyridinyl)- chemical structure, C22H27N5O, CAS 153473-57-5
Piperazine, 1-(1H-indol-2-ylcarbonyl)-4-(3-((1-methylpropyl)amino)-2-pyridinyl)-
CAS 153473-57-5C22H27N5O