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Murcko scaffold

Ring system with 4 rings and 23 atoms

21 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
23
Chemicals
21
With full pages
2
Scaffold SMILES

O=C(c1cc2ccccc2s1)N1CCN(c2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(c1cc2ccccc2s1)N1CCN(c2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 21 of 21 chemicals

[4-(3-Chlorophenyl)piperazin-1-yl]-(3,4-dichloro-1-benzothiophen-2-yl)methanone chemical structure, C19H15Cl3N2OS, CAS 445229-65-2
[4-(3-Chlorophenyl)piperazin-1-yl]-(3,4-dichloro-1-benzothiophen-2-yl)methanone
CAS 445229-65-2C19H15Cl3N2OS
1-[(3,6-Dichloro-1-benzothien-2-yl)carbonyl]-4-(4-fluorophenyl)piperazine chemical structure, C19H15Cl2FN2OS, CAS 445238-32-4
1-[(3,6-Dichloro-1-benzothien-2-yl)carbonyl]-4-(4-fluorophenyl)piperazine
CAS 445238-32-4C19H15Cl2FN2OS
(3,4-Dichloro-1-benzothiophen-2-yl)-[4-(2-fluorophenyl)piperazin-1-yl]methanone chemical structure, C19H15Cl2FN2OS, CAS 444905-35-5
(3,4-Dichloro-1-benzothiophen-2-yl)-[4-(2-fluorophenyl)piperazin-1-yl]methanone
CAS 444905-35-5C19H15Cl2FN2OS
(3-Chloro-6-methyl-1-benzothiophen-2-yl)-[4-(4-fluorophenyl)piperazin-1-yl]methanone chemical structure, C20H18ClFN2OS, CAS 339361-95-4
(3-Chloro-6-methyl-1-benzothiophen-2-yl)-[4-(4-fluorophenyl)piperazin-1-yl]methanone
CAS 339361-95-4C20H18ClFN2OS
1-[(3-Chloro-6-fluoro-1-benzothien-2-yl)carbonyl]-4-(3-chlorophenyl)piperazine chemical structure, C19H15Cl2FN2OS, CAS 612525-41-4
1-[(3-Chloro-6-fluoro-1-benzothien-2-yl)carbonyl]-4-(3-chlorophenyl)piperazine
CAS 612525-41-4C19H15Cl2FN2OS
3,6-Dichlorobenzo[b]thiophen-2-yl 4-(4-methoxyphenyl)piperazinyl ketone chemical structure, C20H18Cl2N2O2S, CAS 488718-67-8
3,6-Dichlorobenzo[b]thiophen-2-yl 4-(4-methoxyphenyl)piperazinyl ketone
CAS 488718-67-8C20H18Cl2N2O2S
(3-Chloro-6-methyl-1-benzothiophen-2-yl)-[4-(2,3-dimethylphenyl)piperazin-1-yl]methanone chemical structure, C22H23ClN2OS, CAS 352693-84-6
(3-Chloro-6-methyl-1-benzothiophen-2-yl)-[4-(2,3-dimethylphenyl)piperazin-1-yl]methanone
CAS 352693-84-6C22H23ClN2OS
1-[4-[4-(3-Chloro-1-benzothiophene-2-carbonyl)piperazin-1-yl]phenyl]ethanone chemical structure, C21H19ClN2O2S, CAS 717857-11-9
1-[4-[4-(3-Chloro-1-benzothiophene-2-carbonyl)piperazin-1-yl]phenyl]ethanone
CAS 717857-11-9C21H19ClN2O2S
1-(3-Chloro-1-benzothiophene-2-carbonyl)-4-(4-methoxyphenyl)piperazine chemical structure, C20H19ClN2O2S, CAS 622354-18-1
1-(3-Chloro-1-benzothiophene-2-carbonyl)-4-(4-methoxyphenyl)piperazine
CAS 622354-18-1C20H19ClN2O2S
(3-Chloro-1-benzothiophen-2-yl)[4-(4-fluorophenyl)piperazino]methanone chemical structure, C19H16ClFN2OS, CAS 351329-77-6
(3-Chloro-1-benzothiophen-2-yl)[4-(4-fluorophenyl)piperazino]methanone
CAS 351329-77-6C19H16ClFN2OS
(3-Chloro-6-methoxybenzo[b]thiophen-2-yl)(4-(4-methoxyphenyl)piperazin-1-yl)methanone chemical structure, C21H21ClN2O3S, CAS 489441-53-4
(3-Chloro-6-methoxybenzo[b]thiophen-2-yl)(4-(4-methoxyphenyl)piperazin-1-yl)methanone
CAS 489441-53-4C21H21ClN2O3S
3-Chloro-6-methoxybenzo[b]thiophen-2-yl 4-phenylpiperazinyl ketone chemical structure, C20H19ClN2O2S, CAS 326007-95-8
3-Chloro-6-methoxybenzo[b]thiophen-2-yl 4-phenylpiperazinyl ketone
CAS 326007-95-8C20H19ClN2O2S
(3-Chloro-1-benzothiophen-2-yl)[4-(4-nitrophenyl)piperazin-1-yl]methanone chemical structure, C19H16ClN3O3S, CAS 347336-56-5
(3-Chloro-1-benzothiophen-2-yl)[4-(4-nitrophenyl)piperazin-1-yl]methanone
CAS 347336-56-5C19H16ClN3O3S
(3-Chloro-1-benzothiophen-2-yl){4-[2-nitro-4-(trifluoromethyl)phenyl]piperazin-1-yl}methanone chemical structure, C20H15ClF3N3O3S, CAS 347337-41-1
(3-Chloro-1-benzothiophen-2-yl){4-[2-nitro-4-(trifluoromethyl)phenyl]piperazin-1-yl}methanone
CAS 347337-41-1C20H15ClF3N3O3S
[4-(2-Chloro-4-nitrophenyl)piperazin-1-yl]-(3,6-dichloro-1-benzothiophen-2-yl)methanone chemical structure, C19H14Cl3N3O3S, CAS 714930-38-8
[4-(2-Chloro-4-nitrophenyl)piperazin-1-yl]-(3,6-dichloro-1-benzothiophen-2-yl)methanone
CAS 714930-38-8C19H14Cl3N3O3S
(3-Chloro-1-benzothiophen-2-yl)-[4-[3-(ethylamino)-4-nitrophenyl]piperazin-1-yl]methanone chemical structure, C21H21ClN4O3S, CAS 717831-56-6
(3-Chloro-1-benzothiophen-2-yl)-[4-[3-(ethylamino)-4-nitrophenyl]piperazin-1-yl]methanone
CAS 717831-56-6C21H21ClN4O3S
[4-(4-Chloro-2-nitrophenyl)piperazin-1-yl]-(3,6-dichloro-1-benzothiophen-2-yl)methanone chemical structure, C19H14Cl3N3O3S, CAS 714224-77-8
[4-(4-Chloro-2-nitrophenyl)piperazin-1-yl]-(3,6-dichloro-1-benzothiophen-2-yl)methanone
CAS 714224-77-8C19H14Cl3N3O3S
(3-Chloro-4-fluoro-1-benzothiophen-2-yl)[4-(4-fluorophenyl)piperazin-1-yl]methanone chemical structure, C19H15ClF2N2OS, CAS 588675-50-7
(3-Chloro-4-fluoro-1-benzothiophen-2-yl)[4-(4-fluorophenyl)piperazin-1-yl]methanone
CAS 588675-50-7C19H15ClF2N2OS
3-Chloro-4-fluorobenzo[b]thiophen-2-yl 4-(3-chlorophenyl)piperazinyl ketone chemical structure, C19H15Cl2FN2OS, CAS 588675-51-8
3-Chloro-4-fluorobenzo[b]thiophen-2-yl 4-(3-chlorophenyl)piperazinyl ketone
CAS 588675-51-8C19H15Cl2FN2OS
(5-Nitro-1-benzothiophen-2-yl)-(4-phenylpiperazin-1-yl)methanone chemical structure, C19H17N3O3S, CAS 361167-81-9
(5-Nitro-1-benzothiophen-2-yl)-(4-phenylpiperazin-1-yl)methanone
CAS 361167-81-9C19H17N3O3S
Piperazine, 1-[(5-aminobenzo[b]thien-2-yl)carbonyl]-4-phenyl- chemical structure, C19H19N3OS, CAS 832102-99-5
Piperazine, 1-[(5-aminobenzo[b]thien-2-yl)carbonyl]-4-phenyl-
CAS 832102-99-5C19H19N3OS