CompoundList
Sign in
Murcko scaffold

2-(4-Phenyl-piperazin-1-ylmethyl)-1H-benzoimidazole scaffold

18 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
22
Chemicals
18
With full pages
5
Scaffold SMILES

c1ccc(N2CCN(Cc3nc4ccccc4[nH]3)CC2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2-(4-Phenyl-piperazin-1-ylmethyl)-1H-benzoimidazole page
Murcko scaffold c1ccc(N2CCN(Cc3nc4ccccc4[nH]3)CC2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 18 of 18 chemicals

2-[4-(4-Methoxy-phenyl)-piperazin-1-ylmethyl]-1H-benzoimidazole chemical structure, C19H22N4O, CAS 159307-85-4
2-[4-(4-Methoxy-phenyl)-piperazin-1-ylmethyl]-1H-benzoimidazole
CAS 159307-85-4C19H22N4O
1-Methyl-2-[(4-phenylpiperazin-1-yl)methyl]-1H-1,3-benzodiazole chemical structure, C19H22N4, CAS 794551-92-1
1-Methyl-2-[(4-phenylpiperazin-1-yl)methyl]-1H-1,3-benzodiazole
CAS 794551-92-1C19H22N4
1-[4-[4-(1H-Benzimidazol-2-ylmethyl)piperazin-1-yl]phenyl]ethanone chemical structure, C20H22N4O, CAS 762256-29-1
1-[4-[4-(1H-Benzimidazol-2-ylmethyl)piperazin-1-yl]phenyl]ethanone
CAS 762256-29-1C20H22N4O
Dopamine D4 receptor antagonist-1 chemical structure, C18H19ClN4, CAS 444724-92-9
Dopamine D4 receptor antagonist-1
CAS 444724-92-9C18H19ClN4
2-[[4-(2-Methoxyphenyl)piperazin-1-yl]methyl]-1H-benzimidazole chemical structure, C19H22N4O, CAS 70006-22-3
2-[[4-(2-Methoxyphenyl)piperazin-1-yl]methyl]-1H-benzimidazole
CAS 70006-22-3C19H22N4O
2-(4-Phenyl-piperazin-1-ylmethyl)-1H-benzoimidazole chemical structure, C18H20N4, CAS 70006-20-1
2-(4-Phenyl-piperazin-1-ylmethyl)-1H-benzoimidazole
CAS 70006-20-1C18H20N4
Benzenemethanol, 4-(4-(1H-benzimidazol-2-ylmethyl)-1-piperazinyl)-2-chloro- chemical structure, C19H21ClN4O, CAS 444725-49-9
Benzenemethanol, 4-(4-(1H-benzimidazol-2-ylmethyl)-1-piperazinyl)-2-chloro-
CAS 444725-49-9C19H21ClN4O
2-{[4-(2-Nitrophenyl)piperazin-1-yl]methyl}-1H-1,3-benzodiazole chemical structure, C18H19N5O2, CAS 474417-30-6
2-{[4-(2-Nitrophenyl)piperazin-1-yl]methyl}-1H-1,3-benzodiazole
CAS 474417-30-6C18H19N5O2
2-[[4-(3,4-Dimethylphenyl)piperazin-1-yl]methyl]-1H-benzimidazole chemical structure, C20H24N4, CAS 726174-00-1
2-[[4-(3,4-Dimethylphenyl)piperazin-1-yl]methyl]-1H-benzimidazole
CAS 726174-00-1C20H24N4
[(2-{[4-(2-Ethoxyphenyl)piperazinyl]methyl}-1-ethylbenzimidazol-5-yl)sulfonyl] dimethylamine chemical structure, C24H33N5O3S, CAS 879437-40-8
[(2-{[4-(2-Ethoxyphenyl)piperazinyl]methyl}-1-ethylbenzimidazol-5-yl)sulfonyl] dimethylamine
CAS 879437-40-8C24H33N5O3S
N-(2-{4-[(1-Methyl-1H-benzimidazol-2-yl)methyl]piperazin-1-yl}phenyl)methanesulfonamide chemical structure, C20H25N5O2S, CAS 903854-22-8
N-(2-{4-[(1-Methyl-1H-benzimidazol-2-yl)methyl]piperazin-1-yl}phenyl)methanesulfonamide
CAS 903854-22-8C20H25N5O2S
N-(2-{4-[(1-Methyl-1H-benzimidazol-2-yl)methyl]piperazin-1-yl}phenyl)butanamide chemical structure, C23H29N5O, CAS 903584-08-7
N-(2-{4-[(1-Methyl-1H-benzimidazol-2-yl)methyl]piperazin-1-yl}phenyl)butanamide
CAS 903584-08-7C23H29N5O
N-(3-Chloro-4-{4-[(1-methyl-1H-benzimidazol-2-yl)methyl]piperazin-1-yl}phenyl)methanesulfonamide chemical structure, C20H24ClN5O2S, CAS 903200-54-4
N-(3-Chloro-4-{4-[(1-methyl-1H-benzimidazol-2-yl)methyl]piperazin-1-yl}phenyl)methanesulfonamide
CAS 903200-54-4C20H24ClN5O2S
3-Methyl-N-(2-{4-[(1-methyl-1H-benzimidazol-2-yl)methyl]piperazin-1-yl}phenyl)butanamide chemical structure, C24H31N5O, CAS 903202-62-0
3-Methyl-N-(2-{4-[(1-methyl-1H-benzimidazol-2-yl)methyl]piperazin-1-yl}phenyl)butanamide
CAS 903202-62-0C24H31N5O
N-(3-Chloro-4-{4-[(1-methyl-1H-benzimidazol-2-yl)methyl]piperazin-1-yl}phenyl)acetamide chemical structure, C21H24ClN5O, CAS 903590-63-6
N-(3-Chloro-4-{4-[(1-methyl-1H-benzimidazol-2-yl)methyl]piperazin-1-yl}phenyl)acetamide
CAS 903590-63-6C21H24ClN5O
N-(3-Chloro-4-{4-[(1-methyl-1H-benzimidazol-2-yl)methyl]piperazin-1-yl}phenyl)propanamide chemical structure, C22H26ClN5O, CAS 903200-69-1
N-(3-Chloro-4-{4-[(1-methyl-1H-benzimidazol-2-yl)methyl]piperazin-1-yl}phenyl)propanamide
CAS 903200-69-1C22H26ClN5O
6-Methyl-2-[(4-phenyl-1-piperazinyl)methyl]-1H-benzimidazole chemical structure, C19H22N4, CAS 946667-93-2
6-Methyl-2-[(4-phenyl-1-piperazinyl)methyl]-1H-benzimidazole
CAS 946667-93-2C19H22N4
2-[[4-(4-Fluorophenyl)piperazin-1-yl]methyl]-1,5-dimethylbenzimidazole chemical structure, C20H23FN4, CAS 915931-13-4
2-[[4-(4-Fluorophenyl)piperazin-1-yl]methyl]-1,5-dimethylbenzimidazole
CAS 915931-13-4C20H23FN4