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Murcko scaffold

Ring system with 4 rings and 23 atoms

33 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
23
Chemicals
33
With full pages
11
Scaffold SMILES

O=C(c1cc2ccccc2o1)N1CCN(c2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(c1cc2ccccc2o1)N1CCN(c2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 33 of 33 chemicals

Piperazine, 1-((6,7-dimethoxy-3-methyl-2-benzofuranyl)carbonyl)-4-phenyl- chemical structure, C22H24N2O4, CAS 40713-20-0
Piperazine, 1-((6,7-dimethoxy-3-methyl-2-benzofuranyl)carbonyl)-4-phenyl-
CAS 40713-20-0C22H24N2O4
1-(2-Methoxyphenyl)-4-(3,4,6-trimethyl-1-benzofuran-2-carbonyl)piperazine chemical structure, C23H26N2O3, CAS 724741-67-7
1-(2-Methoxyphenyl)-4-(3,4,6-trimethyl-1-benzofuran-2-carbonyl)piperazine
CAS 724741-67-7C23H26N2O3
1-(5-Fluoro-3-methyl-1-benzofuran-2-carbonyl)-4-(2-methoxyphenyl)piperazine chemical structure, C21H21FN2O3, CAS 724741-85-9
1-(5-Fluoro-3-methyl-1-benzofuran-2-carbonyl)-4-(2-methoxyphenyl)piperazine
CAS 724741-85-9C21H21FN2O3
2-{4-[(5-Bromo-3-methyl-1-benzofuran-2-yl)carbonyl]-1-piperazinyl}phenyl methyl ether chemical structure, C21H21BrN2O3, CAS 724742-06-7
2-{4-[(5-Bromo-3-methyl-1-benzofuran-2-yl)carbonyl]-1-piperazinyl}phenyl methyl ether
CAS 724742-06-7C21H21BrN2O3
(3,5-Dimethyl-1-benzofuran-2-yl)[4-(4-methoxyphenyl)piperazin-1-yl]methanone chemical structure, C22H24N2O3, CAS 620587-88-4
(3,5-Dimethyl-1-benzofuran-2-yl)[4-(4-methoxyphenyl)piperazin-1-yl]methanone
CAS 620587-88-4C22H24N2O3
(5-Bromo-3-methyl-1-benzofuran-2-yl)-[4-(2,3-dimethylphenyl)piperazin-1-yl]methanone chemical structure, C22H23BrN2O2, CAS 765285-08-3
(5-Bromo-3-methyl-1-benzofuran-2-yl)-[4-(2,3-dimethylphenyl)piperazin-1-yl]methanone
CAS 765285-08-3C22H23BrN2O2
1-Benzofuran-2-yl[4-(2-methoxyphenyl)piperazin-1-yl]methanone chemical structure, C20H20N2O3, CAS 190775-72-5
1-Benzofuran-2-yl[4-(2-methoxyphenyl)piperazin-1-yl]methanone
CAS 190775-72-5C20H20N2O3
1-Benzofuran-2-yl-[4-(5-chloro-2-methylphenyl)piperazin-1-yl]methanone chemical structure, C20H19ClN2O2, CAS 794576-65-1
1-Benzofuran-2-yl-[4-(5-chloro-2-methylphenyl)piperazin-1-yl]methanone
CAS 794576-65-1C20H19ClN2O2
1-Benzofuran-2-yl-[4-(4-fluorophenyl)piperazin-1-yl]methanone chemical structure, C19H17FN2O2, CAS 794560-30-8
1-Benzofuran-2-yl-[4-(4-fluorophenyl)piperazin-1-yl]methanone
CAS 794560-30-8C19H17FN2O2
1-Benzofuran-2-yl-[4-(4-methoxyphenyl)piperazin-1-yl]methanone chemical structure, C20H20N2O3, CAS 872212-42-5
1-Benzofuran-2-yl-[4-(4-methoxyphenyl)piperazin-1-yl]methanone
CAS 872212-42-5C20H20N2O3
1-Benzofuran-2-yl[4-(2-chloro-4-nitrophenyl)piperazin-1-yl]methanone chemical structure, C19H16ClN3O4, CAS 347340-27-6
1-Benzofuran-2-yl[4-(2-chloro-4-nitrophenyl)piperazin-1-yl]methanone
CAS 347340-27-6C19H16ClN3O4
(3-Methyl-1-benzofuran-2-yl)-[4-(4-nitrophenyl)piperazin-1-yl]methanone chemical structure, C20H19N3O4, CAS 403710-79-2
(3-Methyl-1-benzofuran-2-yl)-[4-(4-nitrophenyl)piperazin-1-yl]methanone
CAS 403710-79-2C20H19N3O4
1-Benzofuran-2-yl-[4-[2-nitro-4-(trifluoromethyl)phenyl]piperazin-1-yl]methanone chemical structure, C20H16F3N3O4, CAS 402961-57-3
1-Benzofuran-2-yl-[4-[2-nitro-4-(trifluoromethyl)phenyl]piperazin-1-yl]methanone
CAS 402961-57-3C20H16F3N3O4
1-Benzofuran-2-yl-[4-[3-(ethylamino)-4-nitrophenyl]piperazin-1-yl]methanone chemical structure, C21H22N4O4, CAS 725706-61-6
1-Benzofuran-2-yl-[4-[3-(ethylamino)-4-nitrophenyl]piperazin-1-yl]methanone
CAS 725706-61-6C21H22N4O4
[4-(2-Methoxyphenyl)piperazin-1-yl]-(3-methyl-1-benzofuran-2-yl)methanone chemical structure, C21H22N2O3, CAS 325733-77-5
[4-(2-Methoxyphenyl)piperazin-1-yl]-(3-methyl-1-benzofuran-2-yl)methanone
CAS 325733-77-5C21H22N2O3
RefChem:381674 chemical structure, C22H24N2O2, CAS 588676-07-7
RefChem:381674
CAS 588676-07-7C22H24N2O2
4-(4-Fluorophenyl)piperazinyl 3-methylbenzo[d]furan-2-yl ketone chemical structure, C20H19FN2O2, CAS 588676-08-8
4-(4-Fluorophenyl)piperazinyl 3-methylbenzo[d]furan-2-yl ketone
CAS 588676-08-8C20H19FN2O2
[4-(5-Chloro-2-methylphenyl)piperazin-1-yl]-(7-methoxy-1-benzofuran-2-yl)methanone chemical structure, C21H21ClN2O3, CAS 915881-27-5
[4-(5-Chloro-2-methylphenyl)piperazin-1-yl]-(7-methoxy-1-benzofuran-2-yl)methanone
CAS 915881-27-5C21H21ClN2O3
(4-(2-Fluorophenyl)piperazin-1-yl)(7-methoxybenzofuran-2-yl)methanone chemical structure, C20H19FN2O3, CAS 879070-19-6
(4-(2-Fluorophenyl)piperazin-1-yl)(7-methoxybenzofuran-2-yl)methanone
CAS 879070-19-6C20H19FN2O3
N-[4-[4-(1-Benzofuran-2-carbonyl)piperazin-1-yl]phenyl]butanamide chemical structure, C23H25N3O3, CAS 887693-66-5
N-[4-[4-(1-Benzofuran-2-carbonyl)piperazin-1-yl]phenyl]butanamide
CAS 887693-66-5C23H25N3O3
N-[4-[4-(1-Benzofuran-2-carbonyl)piperazin-1-yl]phenyl]propanamide chemical structure, C22H23N3O3, CAS 887693-54-1
N-[4-[4-(1-Benzofuran-2-carbonyl)piperazin-1-yl]phenyl]propanamide
CAS 887693-54-1C22H23N3O3
N-[4-[4-(1-Benzofuran-2-carbonyl)piperazin-1-yl]phenyl]-2-methylpropanamide chemical structure, C23H25N3O3, CAS 887693-82-5
N-[4-[4-(1-Benzofuran-2-carbonyl)piperazin-1-yl]phenyl]-2-methylpropanamide
CAS 887693-82-5C23H25N3O3
[3-(Methoxymethyl)-1-benzofuran-2-yl]-[4-(2-methylphenyl)piperazin-1-yl]methanone chemical structure, C22H24N2O3, CAS 878224-49-8
[3-(Methoxymethyl)-1-benzofuran-2-yl]-[4-(2-methylphenyl)piperazin-1-yl]methanone
CAS 878224-49-8C22H24N2O3
(2-{[4-(2-Methoxyphenyl)piperazin-1-yl]carbonyl}-1-benzofuran-3-yl)amine chemical structure, C20H21N3O3, CAS 902938-89-0
(2-{[4-(2-Methoxyphenyl)piperazin-1-yl]carbonyl}-1-benzofuran-3-yl)amine
CAS 902938-89-0C20H21N3O3