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Murcko scaffold

Ring system with 3 rings and 24 atoms

22 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
24
Chemicals
22
With full pages
2
Scaffold SMILES

O=C(COc1ccccc1)N(c1ccccc1)C1C=CS(=O)(=O)C1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(COc1ccccc1)N(c1ccccc1)C1C=CS(=O)(=O)C1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 22 of 22 chemicals

N-(2,4-Dimethoxyphenyl)-N-(1,1-dioxido-2,3-dihydrothien-3-yl)-2-phenoxyacetamide chemical structure, C20H21NO6S, CAS 863443-48-5
N-(2,4-Dimethoxyphenyl)-N-(1,1-dioxido-2,3-dihydrothien-3-yl)-2-phenoxyacetamide
CAS 863443-48-5C20H21NO6S
N-(1,1-Dioxido-2,3-dihydrothien-3-yl)-N-(4-methoxyphenyl)-2-phenoxyacetamide chemical structure, C19H19NO5S, CAS 852439-18-0
N-(1,1-Dioxido-2,3-dihydrothien-3-yl)-N-(4-methoxyphenyl)-2-phenoxyacetamide
CAS 852439-18-0C19H19NO5S
2-(4-Bromophenoxy)-N-(1,1-dioxo-2,3-dihydrothiophen-3-yl)-N-phenylacetamide chemical structure, C18H16BrNO4S, CAS 342595-25-9
2-(4-Bromophenoxy)-N-(1,1-dioxo-2,3-dihydrothiophen-3-yl)-N-phenylacetamide
CAS 342595-25-9C18H16BrNO4S
N-(3-Chloro-4-methylphenyl)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)-2-phenoxyacetamide chemical structure, C19H18ClNO4S, CAS 863008-05-3
N-(3-Chloro-4-methylphenyl)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)-2-phenoxyacetamide
CAS 863008-05-3C19H18ClNO4S
N-(3,4-Dimethylphenyl)-N-(1,1-dioxido-2,3-dihydrothien-3-yl)-2-phenoxypropanamide chemical structure, C21H23NO4S, CAS 863021-54-9
N-(3,4-Dimethylphenyl)-N-(1,1-dioxido-2,3-dihydrothien-3-yl)-2-phenoxypropanamide
CAS 863021-54-9C21H23NO4S
N-(4-Bromophenyl)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)-2-phenoxyacetamide chemical structure, C18H16BrNO4S, CAS 863445-55-0
N-(4-Bromophenyl)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)-2-phenoxyacetamide
CAS 863445-55-0C18H16BrNO4S
N-(1,1-Dioxo-2,3-dihydro-1lambda6-thiophen-3-yl)-N-(4-ethoxyphenyl)-2-phenoxyacetamide chemical structure, C20H21NO5S, CAS 863020-87-5
N-(1,1-Dioxo-2,3-dihydro-1lambda6-thiophen-3-yl)-N-(4-ethoxyphenyl)-2-phenoxyacetamide
CAS 863020-87-5C20H21NO5S
2-(4-Chlorophenoxy)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)-N-(4-ethoxyphenyl)acetamide chemical structure, C20H20ClNO5S, CAS 863020-88-6
2-(4-Chlorophenoxy)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)-N-(4-ethoxyphenyl)acetamide
CAS 863020-88-6C20H20ClNO5S
2-(4-Chlorophenoxy)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)-N-(4-methoxyphenyl)acetamide chemical structure, C19H18ClNO5S, CAS 863022-94-0
2-(4-Chlorophenoxy)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)-N-(4-methoxyphenyl)acetamide
CAS 863022-94-0C19H18ClNO5S
N-(3,5-Dimethylphenyl)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)-2-phenoxyacetamide chemical structure, C20H21NO4S, CAS 863445-90-3
N-(3,5-Dimethylphenyl)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)-2-phenoxyacetamide
CAS 863445-90-3C20H21NO4S
2-(4-Chlorophenoxy)-N-(3,5-dimethylphenyl)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)acetamide chemical structure, C20H20ClNO4S, CAS 863445-91-4
2-(4-Chlorophenoxy)-N-(3,5-dimethylphenyl)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)acetamide
CAS 863445-91-4C20H20ClNO4S
2-(4-Chlorophenoxy)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)-N-(4-fluorophenyl)-2-methylpropanamide chemical structure, C20H19ClFNO4S, CAS 863022-47-3
2-(4-Chlorophenoxy)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)-N-(4-fluorophenyl)-2-methylpropanamide
CAS 863022-47-3C20H19ClFNO4S
N-(4-Chlorophenyl)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)-2-phenoxyacetamide chemical structure, C18H16ClNO4S, CAS 852438-14-3
N-(4-Chlorophenyl)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)-2-phenoxyacetamide
CAS 852438-14-3C18H16ClNO4S
N-(1,1-Dioxido-2,3-dihydrothiophen-3-yl)-2-phenoxy-N-(p-tolyl)propanamide chemical structure, C20H21NO4S, CAS 863008-37-1
N-(1,1-Dioxido-2,3-dihydrothiophen-3-yl)-2-phenoxy-N-(p-tolyl)propanamide
CAS 863008-37-1C20H21NO4S
2-(4-Chlorophenoxy)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)-2-methyl-N-(p-tolyl)propanamide chemical structure, C21H22ClNO4S, CAS 852438-26-7
2-(4-Chlorophenoxy)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)-2-methyl-N-(p-tolyl)propanamide
CAS 852438-26-7C21H22ClNO4S
N-(1,1-Dioxo-2,3-dihydro-1lambda6-thiophen-3-yl)-N-(4-ethoxyphenyl)-2-phenoxypropanamide chemical structure, C21H23NO5S, CAS 863020-80-8
N-(1,1-Dioxo-2,3-dihydro-1lambda6-thiophen-3-yl)-N-(4-ethoxyphenyl)-2-phenoxypropanamide
CAS 863020-80-8C21H23NO5S
2-(4-Chlorophenoxy)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)-2-methyl-N-phenylpropanamide chemical structure, C20H20ClNO4S, CAS 852438-59-6
2-(4-Chlorophenoxy)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)-2-methyl-N-phenylpropanamide
CAS 852438-59-6C20H20ClNO4S
N-(3,4-Dimethylphenyl)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)-2-phenoxyacetamide chemical structure, C20H21NO4S, CAS 852438-79-0
N-(3,4-Dimethylphenyl)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)-2-phenoxyacetamide
CAS 852438-79-0C20H21NO4S
N-(1,1-Dioxido-2,3-dihydrothiophen-3-yl)-N-(4-fluorophenyl)-2-phenoxyacetamide chemical structure, C18H16FNO4S, CAS 852438-87-0
N-(1,1-Dioxido-2,3-dihydrothiophen-3-yl)-N-(4-fluorophenyl)-2-phenoxyacetamide
CAS 852438-87-0C18H16FNO4S
2-(4-Chlorophenoxy)-N-(1,1-dioxido-2,3-dihydrothien-3-yl)-N-(4-fluorophenyl)acetamide chemical structure, C18H15ClFNO4S, CAS 852438-89-2
2-(4-Chlorophenoxy)-N-(1,1-dioxido-2,3-dihydrothien-3-yl)-N-(4-fluorophenyl)acetamide
CAS 852438-89-2C18H15ClFNO4S
N-(1,1-Dioxido-2,3-dihydrothiophen-3-yl)-N-(4-methoxyphenyl)-2-phenoxypropanamide chemical structure, C20H21NO5S, CAS 863022-80-4
N-(1,1-Dioxido-2,3-dihydrothiophen-3-yl)-N-(4-methoxyphenyl)-2-phenoxypropanamide
CAS 863022-80-4C20H21NO5S
2-(4-Chlorophenoxy)-N-(1,1-dioxido-2,3-dihydro-3-thiophenyl)-N-(4-isopropylphenyl)acetamide chemical structure, C21H22ClNO4S, CAS 852439-63-5
2-(4-Chlorophenoxy)-N-(1,1-dioxido-2,3-dihydro-3-thiophenyl)-N-(4-isopropylphenyl)acetamide
CAS 852439-63-5C21H22ClNO4S