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Murcko scaffold

1-(Pyridin-2-yl)pyrrolidin-2-one scaffold

39 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
12
Chemicals
39
With full pages
3
Scaffold SMILES

O=C1CCCN1c1ccccn1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-(Pyridin-2-yl)pyrrolidin-2-one page
Murcko scaffold O=C1CCCN1c1ccccn1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 39 of 39 chemicals

1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]pyrrolidin-2-one chemical structure, C10H8ClF3N2O, CAS 338791-67-6
1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]pyrrolidin-2-one
CAS 338791-67-6C10H8ClF3N2O
1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-2-oxopyrrolidine-3-carbonitrile chemical structure, C11H7ClF3N3O, CAS 400087-72-1
1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-2-oxopyrrolidine-3-carbonitrile
CAS 400087-72-1C11H7ClF3N3O
5-Oxo-1-(2-pyridyl)pyrrolidine-3-carboxylic acid chemical structure, C10H10N2O3, CAS 39629-95-3
5-Oxo-1-(2-pyridyl)pyrrolidine-3-carboxylic acid
CAS 39629-95-3C10H10N2O3
1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-3-[(Z)-hydroxyiminomethyl]pyrrolidin-2-one chemical structure, C11H9ClF3N3O2, CAS 339010-73-0
1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-3-[(Z)-hydroxyiminomethyl]pyrrolidin-2-one
CAS 339010-73-0C11H9ClF3N3O2
1-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-2-oxo-3-pyrrolidinecarbaldehyde O-methyloxime chemical structure, C12H11ClF3N3O2, CAS 866051-42-5
1-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-2-oxo-3-pyrrolidinecarbaldehyde O-methyloxime
CAS 866051-42-5C12H11ClF3N3O2
1-(Pyridin-2-yl)pyrrolidin-2-one chemical structure, C9H10N2O, CAS 91596-63-3
1-(Pyridin-2-yl)pyrrolidin-2-one
CAS 91596-63-3C9H10N2O
3-Bromo-1-pyridin-2-ylpyrrolidin-2-one chemical structure, C9H9BrN2O, CAS 178946-27-5
3-Bromo-1-pyridin-2-ylpyrrolidin-2-one
CAS 178946-27-5C9H9BrN2O
1-(6-Bromopyridin-2-yl)pyrrolidin-2-one chemical structure, C9H9BrN2O, CAS 1027511-95-0
1-(6-Bromopyridin-2-yl)pyrrolidin-2-one
CAS 1027511-95-0C9H9BrN2O
1-(4-Bromopyridin-2-yl)pyrrolidin-2-one chemical structure, C9H9BrN2O, CAS 1142194-39-5
1-(4-Bromopyridin-2-yl)pyrrolidin-2-one
CAS 1142194-39-5C9H9BrN2O
1-(5-Bromopyridin-2-yl)pyrrolidin-2-one chemical structure, C9H9BrN2O, CAS 928775-04-6
1-(5-Bromopyridin-2-yl)pyrrolidin-2-one
CAS 928775-04-6C9H9BrN2O
1-(5-Methylpyridin-2-yl)pyrrolidin-2-one chemical structure, C10H12N2O, CAS 876518-95-5
1-(5-Methylpyridin-2-yl)pyrrolidin-2-one
CAS 876518-95-5C10H12N2O
5-Oxo-1-(pyridin-2-yl)pyrrolidine-2-carboxylic acid chemical structure, C10H10N2O3, CAS 2089674-26-8
5-Oxo-1-(pyridin-2-yl)pyrrolidine-2-carboxylic acid
CAS 2089674-26-8C10H10N2O3
1-(5-Nitropyridin-2-yl)pyrrolidin-2-one chemical structure, C9H9N3O3, CAS 1354223-60-1
1-(5-Nitropyridin-2-yl)pyrrolidin-2-one
CAS 1354223-60-1C9H9N3O3
1-(3-Methyl-2-pyridyl)-2-pyrrolidinone chemical structure, C10H12N2O, CAS 91596-66-6
1-(3-Methyl-2-pyridyl)-2-pyrrolidinone
CAS 91596-66-6C10H12N2O
5-Oxo-1-(pyridin-2-yl)pyrrolidine-3-carboxylic acid hydrochloride chemical structure, C10H11ClN2O3, CAS 1384427-91-1
5-Oxo-1-(pyridin-2-yl)pyrrolidine-3-carboxylic acid hydrochloride
CAS 1384427-91-1C10H11ClN2O3
1-(5-Bromo-6-methyl-2-pyridyl)-2-pyrrolidinone chemical structure, C10H11BrN2O, CAS 1288992-37-9
1-(5-Bromo-6-methyl-2-pyridyl)-2-pyrrolidinone
CAS 1288992-37-9C10H11BrN2O
1-(5-Iodo-2-pyridyl)-2-pyrrolidinone chemical structure, C9H9IN2O, CAS 1515256-91-3
1-(5-Iodo-2-pyridyl)-2-pyrrolidinone
CAS 1515256-91-3C9H9IN2O
1-(5-Bromo-3-methyl-2-pyridyl)-2-pyrrolidinone chemical structure, C10H11BrN2O, CAS 1289198-39-5
1-(5-Bromo-3-methyl-2-pyridyl)-2-pyrrolidinone
CAS 1289198-39-5C10H11BrN2O
1-(5-Fluoro-2-pyridyl)-2-pyrrolidinone chemical structure, C9H9FN2O, CAS 1554434-54-6
1-(5-Fluoro-2-pyridyl)-2-pyrrolidinone
CAS 1554434-54-6C9H9FN2O
1-(4-Chloropyridin-2-yl)pyrrolidin-2-one chemical structure, C9H9ClN2O, CAS 1556053-75-8
1-(4-Chloropyridin-2-yl)pyrrolidin-2-one
CAS 1556053-75-8C9H9ClN2O
1-(6-Amino-2-pyridyl)pyrrolidin-2-one chemical structure, C9H11N3O, CAS 1779906-95-4
1-(6-Amino-2-pyridyl)pyrrolidin-2-one
CAS 1779906-95-4C9H11N3O
1-(5-Aminopyridin-2-yl)pyrrolidin-2-one chemical structure, C9H11N3O, CAS 1354223-61-2
1-(5-Aminopyridin-2-yl)pyrrolidin-2-one
CAS 1354223-61-2C9H11N3O
1-(3-Aminopyridin-2-yl)pyrrolidin-2-one chemical structure, C9H11N3O, CAS 1196972-30-1
1-(3-Aminopyridin-2-yl)pyrrolidin-2-one
CAS 1196972-30-1C9H11N3O
1-[4-(Aminomethyl)pyridin-2-yl]pyrrolidin-2-one chemical structure, C10H13N3O, CAS 1784119-14-7
1-[4-(Aminomethyl)pyridin-2-yl]pyrrolidin-2-one
CAS 1784119-14-7C10H13N3O