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Murcko scaffold

Ring system with 5 rings and 33 atoms

143 chemicals on CompoundList share this ring system.

Rings
5
Scaffold atoms
33
Chemicals
143
With full pages
4
Scaffold SMILES

O=c1ncccn1C1CCC(COC(c2ccccc2)(c2ccccc2)c2ccccc2)O1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1ncccn1C1CCC(COC(c2ccccc2)(c2ccccc2)c2ccccc2)O1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 143 chemicals

4-Amino-1-[3,4-dihydroxy-5-(trityloxymethyl)oxolan-2-yl]pyrimidin-2-one chemical structure, C28H27N3O5, CAS 7075-13-0
4-Amino-1-[3,4-dihydroxy-5-(trityloxymethyl)oxolan-2-yl]pyrimidin-2-one
CAS 7075-13-0C28H27N3O5
1-(2,3-Dideoxy-2-fluoro-5-O-trityl-beta-D-erythro-pentofuranosyl)-5-methylcytosine chemical structure, C29H28FN3O3, CAS 132776-31-9
1-(2,3-Dideoxy-2-fluoro-5-O-trityl-beta-D-erythro-pentofuranosyl)-5-methylcytosine
CAS 132776-31-9C29H28FN3O3
N(4)-Tadmd chemical structure, C48H64F3N6O10P, CAS 117032-52-7
N(4)-Tadmd
CAS 117032-52-7C48H64F3N6O10P
3'-Azido-5'-trityl-2',3'-dideoxycytidine chemical structure, C28H26N6O3, CAS 142820-94-8
3'-Azido-5'-trityl-2',3'-dideoxycytidine
CAS 142820-94-8C28H26N6O3
Cytidine, 2'-deoxy-5'-O-(triphenylmethyl)- chemical structure, C28H27N3O4, CAS 18531-20-9
Cytidine, 2'-deoxy-5'-O-(triphenylmethyl)-
CAS 18531-20-9C28H27N3O4
Ctk8F6945 chemical structure, C34H37N3O7, CAS 100898-62-2
Ctk8F6945
CAS 100898-62-2C34H37N3O7
N-(1-((2R,3R,4S,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide chemical structure, C32H33N3O8, CAS 121058-82-0
N-(1-((2R,3R,4S,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide
CAS 121058-82-0C32H33N3O8
5'-O-Dmt-2'-o-methylcytidine chemical structure, C31H33N3O7, CAS 103285-21-8
5'-O-Dmt-2'-o-methylcytidine
CAS 103285-21-8C31H33N3O7
3-((1-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsilyl)oxy)-4-hydroxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)thio)propanenitrile chemical structure, C39H47N3O7SSi, CAS 154665-03-9
3-((1-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsilyl)oxy)-4-hydroxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)thio)propanenitrile
CAS 154665-03-9C39H47N3O7SSi
3-[[(2R,3S,5R)-5-(4-Amino-5-fluoro-2-oxopyrimidin-1-yl)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile chemical structure, C39H47FN5O7P, CAS 143774-48-5
3-[[(2R,3S,5R)-5-(4-Amino-5-fluoro-2-oxopyrimidin-1-yl)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
CAS 143774-48-5C39H47FN5O7P
5'-O-DMT-cytidine chemical structure, C30H31N3O7, CAS 112897-99-1
5'-O-DMT-cytidine
CAS 112897-99-1C30H31N3O7
N(iPr)2P(OCH2CH2CN)(-3)[DMT(-5)]Ribf2Me(b)-cytosin-1-yl chemical structure, C40H50N5O8P, CAS 138906-72-6
N(iPr)2P(OCH2CH2CN)(-3)[DMT(-5)]Ribf2Me(b)-cytosin-1-yl
CAS 138906-72-6C40H50N5O8P
5'-DMTr-dC (Ac)-methylphosphonamidite chemical structure, C39H49N4O7P, CAS 178094-78-5
5'-DMTr-dC (Ac)-methylphosphonamidite
CAS 178094-78-5C39H49N4O7P
N-Acetyl-5'-O-(bis(4-methoxyphenyl)(phenyl)methyl)-2'-O-(tert-butyl(dimethyl)silyl)cytidine chemical structure, C38H47N3O8Si, CAS 121058-85-3
N-Acetyl-5'-O-(bis(4-methoxyphenyl)(phenyl)methyl)-2'-O-(tert-butyl(dimethyl)silyl)cytidine
CAS 121058-85-3C38H47N3O8Si
DMT-N4-Acetyl-2'-Deoxycytidine chemical structure, C32H33N3O7, CAS 100898-63-3
DMT-N4-Acetyl-2'-Deoxycytidine
CAS 100898-63-3C32H33N3O7
(2R,3S,5R)-5-(4-Amino-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite chemical structure, C39H48N5O7P, CAS 140613-57-6
(2R,3S,5R)-5-(4-Amino-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
CAS 140613-57-6C39H48N5O7P
1-((2R,4S,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-4-imino-5-methyl-1,4-dihydropyrimidin-2-ol chemical structure, C31H33N3O6, CAS 176755-83-2
1-((2R,4S,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-4-imino-5-methyl-1,4-dihydropyrimidin-2-ol
CAS 176755-83-2C31H33N3O6
DMT-dC(ac) Phosphoramidite chemical structure, C41H50N5O8P, CAS 154110-40-4
DMT-dC(ac) Phosphoramidite
CAS 154110-40-4C41H50N5O8P
N-[1-[(2R,3R,4R,5R)-5-[[Bis(4-methoxyphenyl)-phenyl-methoxy]methyl]-4-[2-cyanoethoxy-(diisopropylamino)phosphanyl]oxy-3-(2-cyanoethoxymethoxy)tetrahydrofuran-2-yl]-2-oxo-pyrimidin-4-yl]acetamide chemical structure, C45H55N6O10P, CAS 863408-47-3
N-[1-[(2R,3R,4R,5R)-5-[[Bis(4-methoxyphenyl)-phenyl-methoxy]methyl]-4-[2-cyanoethoxy-(diisopropylamino)phosphanyl]oxy-3-(2-cyanoethoxymethoxy)tetrahydrofuran-2-yl]-2-oxo-pyrimidin-4-yl]acetamide
CAS 863408-47-3C45H55N6O10P
5'-O-(4,4'-Dimethoxytrityl)-2'-deoxycytidine chemical structure, C30H31N3O6, CAS 76512-82-8
5'-O-(4,4'-Dimethoxytrityl)-2'-deoxycytidine
CAS 76512-82-8C30H31N3O6
Ac-rC Phosphoramidite chemical structure, C47H64N5O9PSi
Ac-rC Phosphoramidite
C47H64N5O9PSi
Cytidine, 5a(2)-O-[bis(4-methoxyphenyl)phenylmethyl]-2a(2)-deoxy-2a(2)-fluoro-, 3a(2)-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite] chemical structure, C39H47FN5O7P, CAS 200404-36-0
Cytidine, 5a(2)-O-[bis(4-methoxyphenyl)phenylmethyl]-2a(2)-deoxy-2a(2)-fluoro-, 3a(2)-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
CAS 200404-36-0C39H47FN5O7P
IBU-DC Phosphoramidite chemical structure, C43H54N5O8P, CAS 110522-84-4
IBU-DC Phosphoramidite
CAS 110522-84-4C43H54N5O8P
5'-O-DMT-3'-O-TBDMS-Ac-rC chemical structure, C38H47N3O8Si, CAS 123956-65-0
5'-O-DMT-3'-O-TBDMS-Ac-rC
CAS 123956-65-0C38H47N3O8Si