Murcko scaffold
Ring system with 4 rings and 28 atoms
70 chemicals on CompoundList share this ring system.
- Rings
- 4
- Scaffold atoms
- 28
- Chemicals
- 70
- With full pages
- 2
Scaffold SMILES
O=C(NC(=S)Nc1ccccc1)c1cc(-c2ccccc2)nc2ccccc12
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 70 chemicals
![N-[(3-Hydroxyphenyl)carbamothioyl]-2-[3-(2-methylpropoxy)phenyl]quinoline-4-carboxamide chemical structure, C27H25N3O3S, CAS 438195-46-1](/s/QOSQQTDSARXZLH-UHFFFAOYSA-N.svg)
N-[(3-Hydroxyphenyl)carbamothioyl]-2-[3-(2-methylpropoxy)phenyl]quinoline-4-carboxamide
CAS 438195-46-1C27H25N3O3S
![N-[(2-Hydroxyphenyl)carbamothioyl]-2-[3-(2-methylpropoxy)phenyl]quinoline-4-carboxamide chemical structure, C27H25N3O3S, CAS 438196-62-4](/s/IPVGQFLHGVMYGF-UHFFFAOYSA-N.svg)
N-[(2-Hydroxyphenyl)carbamothioyl]-2-[3-(2-methylpropoxy)phenyl]quinoline-4-carboxamide
CAS 438196-62-4C27H25N3O3S
![N-[(2,5-Dimethoxyphenyl)carbamothioyl]-2-(3-propan-2-yloxyphenyl)quinoline-4-carboxamide chemical structure, C28H27N3O4S, CAS 445237-54-7](/s/LKNQQNHVKQOMCU-UHFFFAOYSA-N.svg)
N-[(2,5-Dimethoxyphenyl)carbamothioyl]-2-(3-propan-2-yloxyphenyl)quinoline-4-carboxamide
CAS 445237-54-7C28H27N3O4S
![N-[(2-Methoxyphenyl)carbamothioyl]-2-phenylquinoline-4-carboxamide chemical structure, C24H19N3O2S, CAS 75792-06-2](/s/PQASAMHHPGZMCD-UHFFFAOYSA-N.svg)
N-[(2-Methoxyphenyl)carbamothioyl]-2-phenylquinoline-4-carboxamide
CAS 75792-06-2C24H19N3O2S
![N-[(3-Hydroxyphenyl)carbamothioyl]-2-(3-propan-2-yloxyphenyl)quinoline-4-carboxamide chemical structure, C26H23N3O3S, CAS 445237-84-3](/s/FGLXEZIETVXVEP-UHFFFAOYSA-N.svg)
N-[(3-Hydroxyphenyl)carbamothioyl]-2-(3-propan-2-yloxyphenyl)quinoline-4-carboxamide
CAS 445237-84-3C26H23N3O3S
![N-[(3-Methoxyphenyl)carbamothioyl]-2-phenylquinoline-4-carboxamide chemical structure, C24H19N3O2S, CAS 438211-69-9](/s/UORPDYFRNILSCX-UHFFFAOYSA-N.svg)
N-[(3-Methoxyphenyl)carbamothioyl]-2-phenylquinoline-4-carboxamide
CAS 438211-69-9C24H19N3O2S
![N-[(4-Methoxyphenyl)carbamothioyl]-2-phenylquinoline-4-carboxamide chemical structure, C24H19N3O2S, CAS 75792-07-3](/s/MGIMRCIQYOBBIP-UHFFFAOYSA-N.svg)
N-[(4-Methoxyphenyl)carbamothioyl]-2-phenylquinoline-4-carboxamide
CAS 75792-07-3C24H19N3O2S
![N-[(2-Methylphenyl)carbamothioyl]-2-phenylquinoline-4-carboxamide chemical structure, C24H19N3OS, CAS 75792-03-9](/s/AQIZMZUKERFYOV-UHFFFAOYSA-N.svg)
N-[(2-Methylphenyl)carbamothioyl]-2-phenylquinoline-4-carboxamide
CAS 75792-03-9C24H19N3OS
![Methyl 4-[({[(2-phenyl-4-quinolinyl)carbonyl]amino}carbothioyl)amino]benzoate chemical structure, C25H19N3O3S, CAS 438212-45-4](/s/VKXGPLFAXZZVQV-UHFFFAOYSA-N.svg)
Methyl 4-[({[(2-phenyl-4-quinolinyl)carbonyl]amino}carbothioyl)amino]benzoate
CAS 438212-45-4C25H19N3O3S
![N-[(4-Acetylphenyl)carbamothioyl]-2-phenylquinoline-4-carboxamide chemical structure, C25H19N3O2S, CAS 438213-10-6](/s/LRGAKUBJHHLLFS-UHFFFAOYSA-N.svg)
N-[(4-Acetylphenyl)carbamothioyl]-2-phenylquinoline-4-carboxamide
CAS 438213-10-6C25H19N3O2S
![N-[(3-Nitrophenyl)carbamothioyl]-2-phenylquinoline-4-carboxamide chemical structure, C23H16N4O3S, CAS 438214-33-6](/s/NIHJQLQPSZDXKP-UHFFFAOYSA-N.svg)
N-[(3-Nitrophenyl)carbamothioyl]-2-phenylquinoline-4-carboxamide
CAS 438214-33-6C23H16N4O3S
![N-[(2-Methyl-5-nitrophenyl)carbamothioyl]-2-phenylquinoline-4-carboxamide chemical structure, C24H18N4O3S, CAS 438213-98-0](/s/SCLUPTGQYKJWQJ-UHFFFAOYSA-N.svg)
N-[(2-Methyl-5-nitrophenyl)carbamothioyl]-2-phenylquinoline-4-carboxamide
CAS 438213-98-0C24H18N4O3S
![N-[(2-Iodophenyl)carbamothioyl]-2-(3-propan-2-yloxyphenyl)quinoline-4-carboxamide chemical structure, C26H22IN3O2S, CAS 445237-22-9](/s/VRACDJDZZIMFKF-UHFFFAOYSA-N.svg)
N-[(2-Iodophenyl)carbamothioyl]-2-(3-propan-2-yloxyphenyl)quinoline-4-carboxamide
CAS 445237-22-9C26H22IN3O2S
![N-[(4-Iodo-2-methylphenyl)carbamothioyl]-2-(3-propan-2-yloxyphenyl)quinoline-4-carboxamide chemical structure, C27H24IN3O2S, CAS 445237-26-3](/s/KKZJBJSIVANQGW-UHFFFAOYSA-N.svg)
N-[(4-Iodo-2-methylphenyl)carbamothioyl]-2-(3-propan-2-yloxyphenyl)quinoline-4-carboxamide
CAS 445237-26-3C27H24IN3O2S
![N-[(4-Acetylphenyl)carbamothioyl]-2-(3-propan-2-yloxyphenyl)quinoline-4-carboxamide chemical structure, C28H25N3O3S, CAS 445237-32-1](/s/AIYVGVRYIKWBAM-UHFFFAOYSA-N.svg)
N-[(4-Acetylphenyl)carbamothioyl]-2-(3-propan-2-yloxyphenyl)quinoline-4-carboxamide
CAS 445237-32-1C28H25N3O3S
![N-[(2-Methoxyphenyl)carbamothioyl]-2-(3-propan-2-yloxyphenyl)quinoline-4-carboxamide chemical structure, C27H25N3O3S, CAS 445237-35-4](/s/CTSBVOPTENVQSB-UHFFFAOYSA-N.svg)
N-[(2-Methoxyphenyl)carbamothioyl]-2-(3-propan-2-yloxyphenyl)quinoline-4-carboxamide
CAS 445237-35-4C27H25N3O3S
![Butyl 4-[(2-phenylquinoline-4-carbonyl)carbamothioylamino]benzoate chemical structure, C28H25N3O3S, CAS 445237-37-6](/s/NDCPAOXIYLCJJD-UHFFFAOYSA-N.svg)
Butyl 4-[(2-phenylquinoline-4-carbonyl)carbamothioylamino]benzoate
CAS 445237-37-6C28H25N3O3S
![Ethyl 4-[[2-(3-propan-2-yloxyphenyl)quinoline-4-carbonyl]carbamothioylamino]benzoate chemical structure, C29H27N3O4S, CAS 445237-41-2](/s/BZBQKTWJWFSLHI-UHFFFAOYSA-N.svg)
Ethyl 4-[[2-(3-propan-2-yloxyphenyl)quinoline-4-carbonyl]carbamothioylamino]benzoate
CAS 445237-41-2C29H27N3O4S
![N-[(4-Iodophenyl)carbamothioyl]-2-(3-propan-2-yloxyphenyl)quinoline-4-carboxamide chemical structure, C26H22IN3O2S, CAS 445237-42-3](/s/LRQKAYNLKFNYIQ-UHFFFAOYSA-N.svg)
N-[(4-Iodophenyl)carbamothioyl]-2-(3-propan-2-yloxyphenyl)quinoline-4-carboxamide
CAS 445237-42-3C26H22IN3O2S
![N-[(3-Methylphenyl)carbamothioyl]-2-(3-propan-2-yloxyphenyl)quinoline-4-carboxamide chemical structure, C27H25N3O2S, CAS 445237-49-0](/s/UWAPXEIXZHGXNO-UHFFFAOYSA-N.svg)
N-[(3-Methylphenyl)carbamothioyl]-2-(3-propan-2-yloxyphenyl)quinoline-4-carboxamide
CAS 445237-49-0C27H25N3O2S
![N-[(4-Methoxyphenyl)carbamothioyl]-2-(3-propan-2-yloxyphenyl)quinoline-4-carboxamide chemical structure, C27H25N3O3S, CAS 445237-50-3](/s/FCAZWKAVYXDECF-UHFFFAOYSA-N.svg)
N-[(4-Methoxyphenyl)carbamothioyl]-2-(3-propan-2-yloxyphenyl)quinoline-4-carboxamide
CAS 445237-50-3C27H25N3O3S
![N-[(2-Bromophenyl)carbamothioyl]-2-phenylquinoline-4-carboxamide chemical structure, C23H16BrN3OS, CAS 445237-56-9](/s/VHTIGGQVRYUMNZ-UHFFFAOYSA-N.svg)
N-[(2-Bromophenyl)carbamothioyl]-2-phenylquinoline-4-carboxamide
CAS 445237-56-9C23H16BrN3OS
![N-[Ethyl(phenyl)carbamothioyl]-2-(3-propan-2-yloxyphenyl)quinoline-4-carboxamide chemical structure, C28H27N3O2S, CAS 445237-57-0](/s/UBYRBNORTHQXHK-UHFFFAOYSA-N.svg)
N-[Ethyl(phenyl)carbamothioyl]-2-(3-propan-2-yloxyphenyl)quinoline-4-carboxamide
CAS 445237-57-0C28H27N3O2S
![N-[(2-Methylphenyl)carbamothioyl]-2-(3-propan-2-yloxyphenyl)quinoline-4-carboxamide chemical structure, C27H25N3O2S, CAS 445237-63-8](/s/SBWCLCHJYTVXQT-UHFFFAOYSA-N.svg)
N-[(2-Methylphenyl)carbamothioyl]-2-(3-propan-2-yloxyphenyl)quinoline-4-carboxamide
CAS 445237-63-8C27H25N3O2S
- N-[(2-Bromo-4-methylphenyl)carbamothioyl]-2-(3-propan-2-yloxyphenyl)quinoline-4-carboxamide445237-64-9C27H24BrN3O2S
- N-[(2-Iodophenyl)carbamothioyl]-2-phenylquinoline-4-carboxamide445237-65-0C23H16IN3OS
- N-[(4-Iodo-2-methylphenyl)carbamothioyl]-2-phenylquinoline-4-carboxamide515874-42-7C24H18IN3OS
- N-[(2-Bromo-4-methylphenyl)carbamothioyl]-2-phenylquinoline-4-carboxamide445237-71-8C24H18BrN3OS
- Methyl 4-[[2-(3-propan-2-yloxyphenyl)quinoline-4-carbonyl]carbamothioylamino]benzoate445237-79-6C28H25N3O4S
- N-[(2-Chlorophenyl)carbamothioyl]-2-(3-propan-2-yloxyphenyl)quinoline-4-carboxamide445237-87-6C26H22ClN3O2S
- 2-(4-Chlorophenyl)-N-[(4-iodo-2-methylphenyl)carbamothioyl]quinoline-4-carboxamide445237-90-1C24H17ClIN3OS
- N-[(2-Bromophenyl)carbamothioyl]-2-(3-propan-2-yloxyphenyl)quinoline-4-carboxamide445237-92-3C26H22BrN3O2S
- N-[(2-Methyl-5-nitrophenyl)carbamothioyl]-2-(3-propan-2-yloxyphenyl)quinoline-4-carboxamide445240-59-5C27H24N4O4S
- N-[(2-Methyl-5-nitrophenyl)carbamothioyl]-2-[3-(2-methylpropoxy)phenyl]quinoline-4-carboxamide438195-51-8C28H26N4O4S
- Ethyl 3-[(2-phenylquinoline-4-carbonyl)carbamothioylamino]benzoate438212-66-9C26H21N3O3S
- N-[(2-Bromophenyl)carbamothioyl]-2-[3-(2-methylpropoxy)phenyl]quinoline-4-carboxamide438196-59-9C27H24BrN3O2S
- N-[(2-Bromophenyl)carbamothioyl]-2-(4-chlorophenyl)quinoline-4-carboxamide438613-00-4C23H15BrClN3OS
- N-[(4-Acetylphenyl)carbamothioyl]-2-(4-chlorophenyl)quinoline-4-carboxamide438194-70-8C25H18ClN3O2S
- 2-(4-Chlorophenyl)-N-[(4-ethoxy-2-nitrophenyl)carbamothioyl]quinoline-4-carboxamide438613-57-1C25H19ClN4O4S
- Butyl 4-[[2-[3-(2-methylpropoxy)phenyl]quinoline-4-carbonyl]carbamothioylamino]benzoate438196-30-6C32H33N3O4S
- N-[(2-Bromo-4-methylphenyl)carbamothioyl]-2-(4-chlorophenyl)quinoline-4-carboxamide438613-69-5C24H17BrClN3OS
- N-[(4-Iodophenyl)carbamothioyl]-2-[3-(2-methylpropoxy)phenyl]quinoline-4-carboxamide438196-95-3C27H24IN3O2S
- Ethyl 3-[[2-[3-(2-methylpropoxy)phenyl]quinoline-4-carbonyl]carbamothioylamino]benzoate438196-00-0C30H29N3O4S
- N-[(3-Methoxyphenyl)carbamothioyl]-2-(3-propan-2-yloxyphenyl)quinoline-4-carboxamide438195-32-5C27H25N3O3S
- N-[(4-Methoxyphenyl)carbamothioyl]-2-[3-(2-methylpropoxy)phenyl]quinoline-4-carboxamide438195-54-1C28H27N3O3S
- N-[(2-Chlorophenyl)carbamothioyl]-2-[3-(2-methylpropoxy)phenyl]quinoline-4-carboxamide438194-79-7C27H24ClN3O2S
- 2-[3-(2-Methylpropoxy)phenyl]-N-[(4-nitrophenyl)carbamothioyl]quinoline-4-carboxamide438195-98-3C27H24N4O4S
- Ethyl 4-[[2-[3-(2-methylpropoxy)phenyl]quinoline-4-carbonyl]carbamothioylamino]benzoate438196-51-1C30H29N3O4S
Related scaffolds
Same ring framework with different atoms or bond orders
O=C(COC(=O)c1cc(-c2ccccc2)nc2ccccc12)c1ccccc1202 chemicals
O=C(NN=Cc1ccccc1)c1cc(-c2ccccc2)nc2ccccc1217 chemicals
O=C(NN=Cc1cccnc1)c1cc(-c2ccccc2)nc2ccccc125 chemicals
O=C(NCCc1ccccc1)c1cc(-c2ccccc2)nc2ccccc124 chemicals
c1ccc(-c2nc(NCCCN3CCOCC3)c3ccccc3n2)cc13 chemicals
O=C(NCCN1CCOCC1)c1cc(-c2ccccc2)nc2ccccc122 chemicals
O=C(OCC(=O)N1CCOCC1)c1cc(-c2ccccc2)nc2ccccc122 chemicals
O=C(Cn1c(=O)n(-c2ccccc2)c(=O)c2ccccc21)OCc1ccccc12 chemicals![Scaffold O=C(CSc1nc(-c2ccccc2)nc2[nH]c(=O)[nH]c(=O)c12)Nc1ccccc1](/scaffold/ORPWRIYAPFXEIT-UHFFFAOYSA-N/structure.svg)
O=C(CSc1nc(-c2ccccc2)nc2[nH]c(=O)[nH]c(=O)c12)Nc1ccccc12 chemicals
O=C(NCCc1ccccc1)c1cc(-c2ccccn2)nc2ccccc122 chemicals
O=C(OCC(=O)N1CCCCC1)c1cc(-c2ccccc2)nc2ccccc121 chemical
O=C(NCCC1=CCCCC1)c1cc(-c2ccncc2)nc2ccccc121 chemical