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Murcko scaffold

4-Phenylpiperazin-2-one scaffold

74 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
13
Chemicals
74
With full pages
4
Scaffold SMILES

O=C1CN(c2ccccc2)CCN1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 4-Phenylpiperazin-2-one page
Murcko scaffold O=C1CN(c2ccccc2)CCN1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 74 chemicals

4-(2-Nitrophenyl)piperazin-2-one chemical structure, C10H11N3O3, CAS 955396-16-4
4-(2-Nitrophenyl)piperazin-2-one
CAS 955396-16-4C10H11N3O3
4-(4-Acetylphenyl)-1-hydroxypiperazin-2-one chemical structure, C12H14N2O3, CAS 153805-52-8
4-(4-Acetylphenyl)-1-hydroxypiperazin-2-one
CAS 153805-52-8C12H14N2O3
4-[4-(Trifluoroacetyl)phenyl]piperazin-2-one chemical structure, C12H11F3N2O2, CAS 918129-48-3
4-[4-(Trifluoroacetyl)phenyl]piperazin-2-one
CAS 918129-48-3C12H11F3N2O2
4-(3-Oxopiperazin-1-yl)benzoic acid chemical structure, C11H12N2O3, CAS 918129-41-6
4-(3-Oxopiperazin-1-yl)benzoic acid
CAS 918129-41-6C11H12N2O3
4-(2-Aminophenyl)piperazin-2-one chemical structure, C10H13N3O, CAS 926199-99-7
4-(2-Aminophenyl)piperazin-2-one
CAS 926199-99-7C10H13N3O
4-(2-Amino-6-chlorophenyl)piperazin-2-one chemical structure, C10H12ClN3O, CAS 926260-60-8
4-(2-Amino-6-chlorophenyl)piperazin-2-one
CAS 926260-60-8C10H12ClN3O
4-(4-Amino-2-chlorophenyl)piperazin-2-one chemical structure, C10H12ClN3O, CAS 926250-84-2
4-(4-Amino-2-chlorophenyl)piperazin-2-one
CAS 926250-84-2C10H12ClN3O
4-[2-Amino-4-(trifluoromethyl)phenyl]piperazin-2-one chemical structure, C11H12F3N3O, CAS 882672-41-5
4-[2-Amino-4-(trifluoromethyl)phenyl]piperazin-2-one
CAS 882672-41-5C11H12F3N3O
4-(4-Aminophenyl)piperazin-2-one chemical structure, C10H13N3O, CAS 223786-04-7
4-(4-Aminophenyl)piperazin-2-one
CAS 223786-04-7C10H13N3O
4-(2-Amino-4-chlorophenyl)piperazin-2-one chemical structure, C10H12ClN3O, CAS 926239-48-7
4-(2-Amino-4-chlorophenyl)piperazin-2-one
CAS 926239-48-7C10H12ClN3O
4-(4-Isothiocyanatophenyl)-2-piperazinone chemical structure, C11H11N3OS, CAS 223786-05-8
4-(4-Isothiocyanatophenyl)-2-piperazinone
CAS 223786-05-8C11H11N3OS
4-(4-Aminophenyl)-1-methylpiperazin-2-one chemical structure, C11H15N3O, CAS 223786-01-4
4-(4-Aminophenyl)-1-methylpiperazin-2-one
CAS 223786-01-4C11H15N3O
4-(4-Nitrophenyl)piperazin-2-one chemical structure, C10H11N3O3, CAS 223785-99-7
4-(4-Nitrophenyl)piperazin-2-one
CAS 223785-99-7C10H11N3O3
1-Methyl-4-(4-nitrophenyl)piperazin-2-one chemical structure, C11H13N3O3, CAS 223786-00-3
1-Methyl-4-(4-nitrophenyl)piperazin-2-one
CAS 223786-00-3C11H13N3O3
5-Amino-2-(4-ethyl-3-oxopiperazin-1-yl)fluorobenzene chemical structure, C12H16FN3O, CAS 194350-98-6
5-Amino-2-(4-ethyl-3-oxopiperazin-1-yl)fluorobenzene
CAS 194350-98-6C12H16FN3O
3-Fluoro-4-(4-ethyl-3-oxopiperazin-1-yl)nitrobenzene chemical structure, C12H14FN3O3, CAS 194350-97-5
3-Fluoro-4-(4-ethyl-3-oxopiperazin-1-yl)nitrobenzene
CAS 194350-97-5C12H14FN3O3
3-Fluoro-4-(4-methyl-3-oxopiperazin-1-yl)nitrobenzene chemical structure, C11H12FN3O3, CAS 194350-89-5
3-Fluoro-4-(4-methyl-3-oxopiperazin-1-yl)nitrobenzene
CAS 194350-89-5C11H12FN3O3
4-(4-Amino-2-fluorophenyl)-1-methylpiperazin-2-one chemical structure, C11H14FN3O, CAS 194350-90-8
4-(4-Amino-2-fluorophenyl)-1-methylpiperazin-2-one
CAS 194350-90-8C11H14FN3O
4-(2-Amino-4-bromophenyl)piperazin-2-one chemical structure, C10H12BrN3O, CAS 1016845-08-1
4-(2-Amino-4-bromophenyl)piperazin-2-one
CAS 1016845-08-1C10H12BrN3O
4-(4-Aminophenyl)-1-ethyl-2-piperazinone chemical structure, C12H17N3O, CAS 1082266-88-3
4-(4-Aminophenyl)-1-ethyl-2-piperazinone
CAS 1082266-88-3C12H17N3O
3-Nitro-4-(3-oxo-1-piperazinyl)benzoic acid chemical structure, C11H11N3O5, CAS 1019359-77-3
3-Nitro-4-(3-oxo-1-piperazinyl)benzoic acid
CAS 1019359-77-3C11H11N3O5
4-[4-(Aminomethyl)phenyl]piperazin-2-one chemical structure, C11H15N3O, CAS 1019575-67-7
4-[4-(Aminomethyl)phenyl]piperazin-2-one
CAS 1019575-67-7C11H15N3O
4-(3-Oxopiperazin-1-yl)benzonitrile chemical structure, C11H11N3O, CAS 1019601-14-9
4-(3-Oxopiperazin-1-yl)benzonitrile
CAS 1019601-14-9C11H11N3O
4-(2-Amino-4-fluorophenyl)piperazin-2-one chemical structure, C10H12FN3O, CAS 1019581-56-6
4-(2-Amino-4-fluorophenyl)piperazin-2-one
CAS 1019581-56-6C10H12FN3O