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Murcko scaffold

Ring system with 4 rings and 24 atoms

24 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
24
Chemicals
24
With full pages
4
Scaffold SMILES

c1ccc(-c2noc(CN3CCN(c4ccccc4)CC3)n2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(-c2noc(CN3CCN(c4ccccc4)CC3)n2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 24 of 24 chemicals

1-(4-Fluorophenyl)-4-[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]piperazine chemical structure, C19H19FN4O, CAS 667879-31-4
1-(4-Fluorophenyl)-4-[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]piperazine
CAS 667879-31-4C19H19FN4O
1-{[3-(4-Methylphenyl)-1,2,4-oxadiazol-5-yl]methyl}-4-phenylpiperazine chemical structure, C20H22N4O, CAS 693269-95-3
1-{[3-(4-Methylphenyl)-1,2,4-oxadiazol-5-yl]methyl}-4-phenylpiperazine
CAS 693269-95-3C20H22N4O
1-(2-Fluorophenyl)-4-[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]piperazine chemical structure, C19H19FN4O, CAS 708990-16-3
1-(2-Fluorophenyl)-4-[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]piperazine
CAS 708990-16-3C19H19FN4O
1-(2-Methoxyphenyl)-4-{[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl}piperazine chemical structure, C21H24N4O2, CAS 727366-25-8
1-(2-Methoxyphenyl)-4-{[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl}piperazine
CAS 727366-25-8C21H24N4O2
1-(4-Methoxyphenyl)-4-{[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl}piperazine chemical structure, C21H24N4O2, CAS 692774-03-1
1-(4-Methoxyphenyl)-4-{[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl}piperazine
CAS 692774-03-1C21H24N4O2
1-{[3-(4-Chlorophenyl)-1,2,4-oxadiazol-5-yl]methyl}-4-phenylpiperazine chemical structure, C19H19ClN4O, CAS 832683-27-9
1-{[3-(4-Chlorophenyl)-1,2,4-oxadiazol-5-yl]methyl}-4-phenylpiperazine
CAS 832683-27-9C19H19ClN4O
1-{[3-(3,4-Dimethoxyphenyl)-1,2,4-oxadiazol-5-yl]methyl}-4-(2-methoxyphenyl)piperazine chemical structure, C22H26N4O4, CAS 767322-75-8
1-{[3-(3,4-Dimethoxyphenyl)-1,2,4-oxadiazol-5-yl]methyl}-4-(2-methoxyphenyl)piperazine
CAS 767322-75-8C22H26N4O4
1-{[3-(4-Chlorophenyl)-1,2,4-oxadiazol-5-yl]methyl}-4-(2-methoxyphenyl)piperazine chemical structure, C20H21ClN4O2, CAS 833443-16-6
1-{[3-(4-Chlorophenyl)-1,2,4-oxadiazol-5-yl]methyl}-4-(2-methoxyphenyl)piperazine
CAS 833443-16-6C20H21ClN4O2
1-{[3-(3-Methylphenyl)-1,2,4-oxadiazol-5-yl]methyl}-4-phenylpiperazine chemical structure, C20H22N4O, CAS 836662-16-9
1-{[3-(3-Methylphenyl)-1,2,4-oxadiazol-5-yl]methyl}-4-phenylpiperazine
CAS 836662-16-9C20H22N4O
1-(3-Chlorophenyl)-4-{[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl}piperazine chemical structure, C20H21ClN4O, CAS 693813-15-9
1-(3-Chlorophenyl)-4-{[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl}piperazine
CAS 693813-15-9C20H21ClN4O
1-(2-Methoxyphenyl)-4-[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]piperazine chemical structure, C20H22N4O2, CAS 693815-86-0
1-(2-Methoxyphenyl)-4-[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]piperazine
CAS 693815-86-0C20H22N4O2
5-[[4-(4-Methoxyphenyl)piperazin-1-yl]methyl]-3-phenyl-1,2,4-oxadiazole chemical structure, C20H22N4O2, CAS 708285-75-0
5-[[4-(4-Methoxyphenyl)piperazin-1-yl]methyl]-3-phenyl-1,2,4-oxadiazole
CAS 708285-75-0C20H22N4O2
1-(4-Methoxyphenyl)-4-{[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]methyl}piperazine chemical structure, C21H24N4O3, CAS 833434-61-0
1-(4-Methoxyphenyl)-4-{[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]methyl}piperazine
CAS 833434-61-0C21H24N4O3
1-{[3-(4-Chlorophenyl)-1,2,4-oxadiazol-5-yl]methyl}-4-(2,6-dimethylphenyl)piperazine chemical structure, C21H23ClN4O, CAS 860784-30-1
1-{[3-(4-Chlorophenyl)-1,2,4-oxadiazol-5-yl]methyl}-4-(2,6-dimethylphenyl)piperazine
CAS 860784-30-1C21H23ClN4O
1-(4-Nitrophenyl)-4-[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]piperazine chemical structure, C19H19N5O3, CAS 587006-22-2
1-(4-Nitrophenyl)-4-[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]piperazine
CAS 587006-22-2C19H19N5O3
3-(2-Chlorophenyl)-5-[[4-(4-methoxyphenyl)piperazin-1-yl]methyl]-1,2,4-oxadiazole chemical structure, C20H21ClN4O2, CAS 727366-30-5
3-(2-Chlorophenyl)-5-[[4-(4-methoxyphenyl)piperazin-1-yl]methyl]-1,2,4-oxadiazole
CAS 727366-30-5C20H21ClN4O2
1-(4-Methoxyphenyl)-4-{[3-(3-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl}piperazine chemical structure, C21H24N4O2, CAS 876893-40-2
1-(4-Methoxyphenyl)-4-{[3-(3-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl}piperazine
CAS 876893-40-2C21H24N4O2
1-{[3-(4-Chlorophenyl)-1,2,4-oxadiazol-5-yl]methyl}-4-(4-fluorophenyl)piperazine chemical structure, C19H18ClFN4O, CAS 890325-21-0
1-{[3-(4-Chlorophenyl)-1,2,4-oxadiazol-5-yl]methyl}-4-(4-fluorophenyl)piperazine
CAS 890325-21-0C19H18ClFN4O
1-{[3-(4-Chlorophenyl)-1,2,4-oxadiazol-5-yl]methyl}-4-(4-methoxyphenyl)piperazine chemical structure, C20H21ClN4O2, CAS 878974-86-8
1-{[3-(4-Chlorophenyl)-1,2,4-oxadiazol-5-yl]methyl}-4-(4-methoxyphenyl)piperazine
CAS 878974-86-8C20H21ClN4O2
1-(3-Chlorophenyl)-4-{[3-(3-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl}piperazine chemical structure, C20H21ClN4O, CAS 878974-82-4
1-(3-Chlorophenyl)-4-{[3-(3-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl}piperazine
CAS 878974-82-4C20H21ClN4O
1-(2-Fluorophenyl)-4-{[3-(3-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl}piperazine chemical structure, C20H21FN4O, CAS 878974-78-8
1-(2-Fluorophenyl)-4-{[3-(3-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl}piperazine
CAS 878974-78-8C20H21FN4O
1-(4-Fluorophenyl)-4-{[3-(3-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl}piperazine chemical structure, C20H21FN4O, CAS 890324-61-5
1-(4-Fluorophenyl)-4-{[3-(3-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl}piperazine
CAS 890324-61-5C20H21FN4O
2-{4-[(3-Phenyl-1,2,4-oxadiazol-5-yl)methyl]piperazin-1-yl}phenol chemical structure, C19H20N4O2, CAS 878562-41-5
2-{4-[(3-Phenyl-1,2,4-oxadiazol-5-yl)methyl]piperazin-1-yl}phenol
CAS 878562-41-5C19H20N4O2
1-{[3-(2-Chlorophenyl)-1,2,4-oxadiazol-5-yl]methyl}-4-(2-fluorophenyl)piperazine chemical structure, C19H18ClFN4O, CAS 924425-09-2
1-{[3-(2-Chlorophenyl)-1,2,4-oxadiazol-5-yl]methyl}-4-(2-fluorophenyl)piperazine
CAS 924425-09-2C19H18ClFN4O