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Murcko scaffold

1-Phenyl-4-(4-phenylpiperazine-1-carbonyl)pyrrolidin-2-one scaffold

23 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 26
Chemicals: 23
With full pages: 9

Scaffold SMILES

O=C(C1CC(=O)N(c2ccccc2)C1)N1CCN(c2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold Open the 1-Phenyl-4-(4-phenylpiperazine-1-carbonyl)pyrrolidin-2-one page

Murcko scaffold O=C(C1CC(=O)N(c2ccccc2)C1)N1CCN(c2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 23 of 23 chemicals

1-(4-Methylphenyl)-4-(4-phenylpiperazine-1-carbonyl)pyrrolidin-2-one chemical structure, C22H25N3O2, CAS 785710-86-3

1-(4-Methylphenyl)-4-(4-phenylpiperazine-1-carbonyl)pyrrolidin-2-one

CAS 785710-86-3C₂₂H₂₅N₃O₂

1-(4-Methylphenyl)-4-[4-(4-nitrophenyl)piperazine-1-carbonyl]pyrrolidin-2-one chemical structure, C22H24N4O4, CAS 825597-75-9

1-(4-Methylphenyl)-4-[4-(4-nitrophenyl)piperazine-1-carbonyl]pyrrolidin-2-one

CAS 825597-75-9C₂₂H₂₄N₄O₄

1-(4-Methoxyphenyl)-4-[4-(2-methoxyphenyl)piperazine-1-carbonyl]pyrrolidin-2-one chemical structure, C23H27N3O4, CAS 878426-50-7

1-(4-Methoxyphenyl)-4-[4-(2-methoxyphenyl)piperazine-1-carbonyl]pyrrolidin-2-one

CAS 878426-50-7C₂₃H₂₇N₃O₄

1-(4-Fluorophenyl)-4-[4-(4-fluorophenyl)piperazine-1-carbonyl]pyrrolidin-2-one chemical structure, C21H21F2N3O2, CAS 879584-14-2

1-(4-Fluorophenyl)-4-[4-(4-fluorophenyl)piperazine-1-carbonyl]pyrrolidin-2-one

CAS 879584-14-2C₂₁H₂₁F₂N₃O₂

1-(4-Fluorophenyl)-4-(4-phenylpiperazine-1-carbonyl)pyrrolidin-2-one chemical structure, C21H22FN3O2, CAS 879583-86-5

1-(4-Fluorophenyl)-4-(4-phenylpiperazine-1-carbonyl)pyrrolidin-2-one

CAS 879583-86-5C₂₁H₂₂FN₃O₂

4-{[4-(2-Fluorophenyl)piperazin-1-yl]carbonyl}-1-phenylpyrrolidin-2-one chemical structure, C21H22FN3O2, CAS 892714-13-5

4-{[4-(2-Fluorophenyl)piperazin-1-yl]carbonyl}-1-phenylpyrrolidin-2-one

CAS 892714-13-5C₂₁H₂₂FN₃O₂

1-(4-Methoxyphenyl)-4-(4-phenylpiperazine-1-carbonyl)pyrrolidin-2-one chemical structure, C22H25N3O3, CAS 881782-39-4

1-(4-Methoxyphenyl)-4-(4-phenylpiperazine-1-carbonyl)pyrrolidin-2-one

CAS 881782-39-4C₂₂H₂₅N₃O₃

1-Phenyl-4-(4-phenylpiperazine-1-carbonyl)pyrrolidin-2-one chemical structure, C21H23N3O2, CAS 896925-63-6

1-Phenyl-4-(4-phenylpiperazine-1-carbonyl)pyrrolidin-2-one

CAS 896925-63-6C₂₁H₂₃N₃O₂

4-[4-(4-Fluorophenyl)piperazine-1-carbonyl]-1-phenylpyrrolidin-2-one chemical structure, C21H22FN3O2, CAS 879595-50-3

4-[4-(4-Fluorophenyl)piperazine-1-carbonyl]-1-phenylpyrrolidin-2-one

CAS 879595-50-3C₂₁H₂₂FN₃O₂

4-[4-(2-Methoxyphenyl)piperazine-1-carbonyl]-1-phenylpyrrolidin-2-one chemical structure, C22H25N3O3, CAS 878441-91-9

4-[4-(2-Methoxyphenyl)piperazine-1-carbonyl]-1-phenylpyrrolidin-2-one

CAS 878441-91-9C₂₂H₂₅N₃O₃

4-{[4-(2-Fluorophenyl)piperazin-1-yl]carbonyl}-1-(4-methylphenyl)pyrrolidin-2-one chemical structure, C22H24FN3O2, CAS 723300-03-6

4-{[4-(2-Fluorophenyl)piperazin-1-yl]carbonyl}-1-(4-methylphenyl)pyrrolidin-2-one

CAS 723300-03-6C₂₂H₂₄FN₃O₂

1-(4-Chlorophenyl)-4-[(4-phenylpiperazin-1-yl)carbonyl]pyrrolidin-2-one chemical structure, C21H22ClN3O2, CAS 892698-75-8

1-(4-Chlorophenyl)-4-[(4-phenylpiperazin-1-yl)carbonyl]pyrrolidin-2-one

CAS 892698-75-8C₂₁H₂₂ClN₃O₂

1-(2-Methylphenyl)-4-[(4-phenylpiperazin-1-yl)carbonyl]pyrrolidin-2-one chemical structure, C22H25N3O2, CAS 896927-70-1

1-(2-Methylphenyl)-4-[(4-phenylpiperazin-1-yl)carbonyl]pyrrolidin-2-one

CAS 896927-70-1C₂₂H₂₅N₃O₂

1-(2,5-Dimethoxyphenyl)-4-[(4-phenylpiperazin-1-yl)carbonyl]pyrrolidin-2-one chemical structure, C23H27N3O4, CAS 924970-39-8

1-(2,5-Dimethoxyphenyl)-4-[(4-phenylpiperazin-1-yl)carbonyl]pyrrolidin-2-one

CAS 924970-39-8C₂₃H₂₇N₃O₄

4-{[4-(4-Fluorophenyl)piperazin-1-yl]carbonyl}-1-(3-methylphenyl)pyrrolidin-2-one chemical structure, C22H24FN3O2, CAS 903023-03-0

4-{[4-(4-Fluorophenyl)piperazin-1-yl]carbonyl}-1-(3-methylphenyl)pyrrolidin-2-one

CAS 903023-03-0C₂₂H₂₄FN₃O₂

1-(2,4-Dimethoxyphenyl)-4-{[4-(4-fluorophenyl)piperazin-1-yl]carbonyl}pyrrolidin-2-one chemical structure, C23H26FN3O4, CAS 931371-30-1

1-(2,4-Dimethoxyphenyl)-4-{[4-(4-fluorophenyl)piperazin-1-yl]carbonyl}pyrrolidin-2-one

CAS 931371-30-1C₂₃H₂₆FN₃O₄

1-(2-Methoxy-5-methylphenyl)-4-[(4-phenylpiperazin-1-yl)carbonyl]pyrrolidin-2-one chemical structure, C23H27N3O3, CAS 925889-31-2

1-(2-Methoxy-5-methylphenyl)-4-[(4-phenylpiperazin-1-yl)carbonyl]pyrrolidin-2-one

CAS 925889-31-2C₂₃H₂₇N₃O₃

4-[4-(2,3-Dimethylphenyl)piperazine-1-carbonyl]-1-(4-methoxyphenyl)pyrrolidin-2-one chemical structure, C24H29N3O3, CAS 881789-81-7

4-[4-(2,3-Dimethylphenyl)piperazine-1-carbonyl]-1-(4-methoxyphenyl)pyrrolidin-2-one

CAS 881789-81-7C₂₄H₂₉N₃O₃

1-(4-Methoxyphenyl)-4-[4-(3-methylphenyl)piperazine-1-carbonyl]pyrrolidin-2-one chemical structure, C23H27N3O3, CAS 1252902-01-4

1-(4-Methoxyphenyl)-4-[4-(3-methylphenyl)piperazine-1-carbonyl]pyrrolidin-2-one

CAS 1252902-01-4C₂₃H₂₇N₃O₃

1-(4-Methoxyphenyl)-4-[4-(4-methoxyphenyl)piperazine-1-carbonyl]pyrrolidin-2-one chemical structure, C23H27N3O4, CAS 1252851-86-7

1-(4-Methoxyphenyl)-4-[4-(4-methoxyphenyl)piperazine-1-carbonyl]pyrrolidin-2-one

CAS 1252851-86-7C₂₃H₂₇N₃O₄

4-[4-(4-Chlorophenyl)piperazine-1-carbonyl]-1-(4-methoxyphenyl)pyrrolidin-2-one chemical structure, C22H24ClN3O3, CAS 1252877-78-3

4-[4-(4-Chlorophenyl)piperazine-1-carbonyl]-1-(4-methoxyphenyl)pyrrolidin-2-one

CAS 1252877-78-3C₂₂H₂₄ClN₃O₃

1-(4-Methoxyphenyl)-4-[4-(2-methylphenyl)piperazine-1-carbonyl]pyrrolidin-2-one chemical structure, C23H27N3O3, CAS 1252819-22-9

1-(4-Methoxyphenyl)-4-[4-(2-methylphenyl)piperazine-1-carbonyl]pyrrolidin-2-one

CAS 1252819-22-9C₂₃H₂₇N₃O₃

1-(4-Methoxyphenyl)-4-[4-(4-methylphenyl)piperazine-1-carbonyl]pyrrolidin-2-one chemical structure, C23H27N3O3, CAS 1252905-48-8

1-(4-Methoxyphenyl)-4-[4-(4-methylphenyl)piperazine-1-carbonyl]pyrrolidin-2-one

CAS 1252905-48-8C₂₃H₂₇N₃O₃