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Murcko scaffold

Ring system with 4 rings and 25 atoms

62 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
62
With full pages
7
Scaffold SMILES

S=C(c1ccc(-c2ccccc2)o1)N1CCN(c2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold S=C(c1ccc(-c2ccccc2)o1)N1CCN(c2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 62 chemicals

[4-(3-Methylphenyl)piperazin-1-yl]-[5-(2-nitrophenyl)furan-2-yl]methanethione chemical structure, C22H21N3O3S, CAS 314260-03-2
[4-(3-Methylphenyl)piperazin-1-yl]-[5-(2-nitrophenyl)furan-2-yl]methanethione
CAS 314260-03-2C22H21N3O3S
[5-(2,4-Dichlorophenyl)furan-2-yl][4-(3-methylphenyl)piperazin-1-yl]methanethione chemical structure, C22H20Cl2N2OS, CAS 6149-59-3
[5-(2,4-Dichlorophenyl)furan-2-yl][4-(3-methylphenyl)piperazin-1-yl]methanethione
CAS 6149-59-3C22H20Cl2N2OS
(4-Phenylpiperazin-1-yl)(5-(3-(trifluoromethyl)phenyl)furan-2-yl)methanethione chemical structure, C22H19F3N2OS, CAS 301339-02-6
(4-Phenylpiperazin-1-yl)(5-(3-(trifluoromethyl)phenyl)furan-2-yl)methanethione
CAS 301339-02-6C22H19F3N2OS
(5-(2-Chlorophenyl)furan-2-yl)(4-(m-tolyl)piperazin-1-yl)methanethione chemical structure, C22H21ClN2OS, CAS 476340-80-4
(5-(2-Chlorophenyl)furan-2-yl)(4-(m-tolyl)piperazin-1-yl)methanethione
CAS 476340-80-4C22H21ClN2OS
(5-(2,4-Dichlorophenyl)furan-2-yl)(4-phenylpiperazin-1-yl)methanethione chemical structure, C21H18Cl2N2OS, CAS 301339-00-4
(5-(2,4-Dichlorophenyl)furan-2-yl)(4-phenylpiperazin-1-yl)methanethione
CAS 301339-00-4C21H18Cl2N2OS
(5-(3,4-Dichlorophenyl)furan-2-yl)(4-phenylpiperazin-1-yl)methanethione chemical structure, C21H18Cl2N2OS, CAS 301338-98-7
(5-(3,4-Dichlorophenyl)furan-2-yl)(4-phenylpiperazin-1-yl)methanethione
CAS 301338-98-7C21H18Cl2N2OS
[5-(2,3-Dichlorophenyl)furan-2-yl]-(4-phenylpiperazin-1-yl)methanethione chemical structure, C21H18Cl2N2OS, CAS 301338-99-8
[5-(2,3-Dichlorophenyl)furan-2-yl]-(4-phenylpiperazin-1-yl)methanethione
CAS 301338-99-8C21H18Cl2N2OS
(5-(4-Fluorophenyl)furan-2-yl)(4-phenylpiperazin-1-yl)methanethione chemical structure, C21H19FN2OS, CAS 315240-97-2
(5-(4-Fluorophenyl)furan-2-yl)(4-phenylpiperazin-1-yl)methanethione
CAS 315240-97-2C21H19FN2OS
[4-(4-Methylphenyl)piperazin-1-yl]-[5-(3-nitrophenyl)furan-2-yl]methanethione chemical structure, C22H21N3O3S, CAS 327076-93-7
[4-(4-Methylphenyl)piperazin-1-yl]-[5-(3-nitrophenyl)furan-2-yl]methanethione
CAS 327076-93-7C22H21N3O3S
(4-(4-Fluorophenyl)piperazin-1-yl)(5-(3-nitrophenyl)furan-2-yl)methanethione chemical structure, C21H18FN3O3S, CAS 327076-94-8
(4-(4-Fluorophenyl)piperazin-1-yl)(5-(3-nitrophenyl)furan-2-yl)methanethione
CAS 327076-94-8C21H18FN3O3S
(4-(p-Tolyl)piperazin-1-yl)(5-(3-(trifluoromethyl)phenyl)furan-2-yl)methanethione chemical structure, C23H21F3N2OS, CAS 394238-07-4
(4-(p-Tolyl)piperazin-1-yl)(5-(3-(trifluoromethyl)phenyl)furan-2-yl)methanethione
CAS 394238-07-4C23H21F3N2OS
(5-(2-Nitrophenyl)furan-2-yl)(4-phenylpiperazin-1-yl)methanethione chemical structure, C21H19N3O3S, CAS 301339-03-7
(5-(2-Nitrophenyl)furan-2-yl)(4-phenylpiperazin-1-yl)methanethione
CAS 301339-03-7C21H19N3O3S
(5-(4-Bromophenyl)furan-2-yl)(4-phenylpiperazin-1-yl)methanethione chemical structure, C21H19BrN2OS, CAS 448216-69-1
(5-(4-Bromophenyl)furan-2-yl)(4-phenylpiperazin-1-yl)methanethione
CAS 448216-69-1C21H19BrN2OS
(5-(3-Nitrophenyl)furan-2-yl)(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)methanethione chemical structure, C22H18F3N3O3S, CAS 578698-46-1
(5-(3-Nitrophenyl)furan-2-yl)(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)methanethione
CAS 578698-46-1C22H18F3N3O3S
(5-(3-Chlorophenyl)furan-2-yl)(4-phenylpiperazin-1-yl)methanethione chemical structure, C21H19ClN2OS, CAS 301338-97-6
(5-(3-Chlorophenyl)furan-2-yl)(4-phenylpiperazin-1-yl)methanethione
CAS 301338-97-6C21H19ClN2OS
(5-(2-Chlorophenyl)furan-2-yl)(4-(o-tolyl)piperazin-1-yl)methanethione chemical structure, C22H21ClN2OS, CAS 459192-65-5
(5-(2-Chlorophenyl)furan-2-yl)(4-(o-tolyl)piperazin-1-yl)methanethione
CAS 459192-65-5C22H21ClN2OS
(5-(4-Chlorophenyl)furan-2-yl)(4-(o-tolyl)piperazin-1-yl)methanethione chemical structure, C22H21ClN2OS, CAS 391890-77-0
(5-(4-Chlorophenyl)furan-2-yl)(4-(o-tolyl)piperazin-1-yl)methanethione
CAS 391890-77-0C22H21ClN2OS
(5-(p-Tolyl)furan-2-yl)(4-(o-tolyl)piperazin-1-yl)methanethione chemical structure, C23H24N2OS, CAS 459192-57-5
(5-(p-Tolyl)furan-2-yl)(4-(o-tolyl)piperazin-1-yl)methanethione
CAS 459192-57-5C23H24N2OS
(5-Phenylfuran-2-yl)(4-(o-tolyl)piperazin-1-yl)methanethione chemical structure, C22H22N2OS, CAS 391890-75-8
(5-Phenylfuran-2-yl)(4-(o-tolyl)piperazin-1-yl)methanethione
CAS 391890-75-8C22H22N2OS
(4-(3-Chlorophenyl)piperazin-1-yl)(5-(4-nitrophenyl)furan-2-yl)methanethione chemical structure, C21H18ClN3O3S, CAS 327074-74-8
(4-(3-Chlorophenyl)piperazin-1-yl)(5-(4-nitrophenyl)furan-2-yl)methanethione
CAS 327074-74-8C21H18ClN3O3S
(5-(2-Chlorophenyl)furan-2-yl)(4-(4-fluorophenyl)piperazin-1-yl)methanethione chemical structure, C21H18ClFN2OS, CAS 843617-58-3
(5-(2-Chlorophenyl)furan-2-yl)(4-(4-fluorophenyl)piperazin-1-yl)methanethione
CAS 843617-58-3C21H18ClFN2OS
(5-(2,4-Dichlorophenyl)furan-2-yl)(4-(4-fluorophenyl)piperazin-1-yl)methanethione chemical structure, C21H17Cl2FN2OS, CAS 840518-90-3
(5-(2,4-Dichlorophenyl)furan-2-yl)(4-(4-fluorophenyl)piperazin-1-yl)methanethione
CAS 840518-90-3C21H17Cl2FN2OS
(5-(4-Nitrophenyl)furan-2-yl)(4-(o-tolyl)piperazin-1-yl)methanethione chemical structure, C22H21N3O3S, CAS 315242-10-5
(5-(4-Nitrophenyl)furan-2-yl)(4-(o-tolyl)piperazin-1-yl)methanethione
CAS 315242-10-5C22H21N3O3S
(5-(4-Chlorophenyl)furan-2-yl)(4-(4-fluorophenyl)piperazin-1-yl)methanethione chemical structure, C21H18ClFN2OS, CAS 840515-93-7
(5-(4-Chlorophenyl)furan-2-yl)(4-(4-fluorophenyl)piperazin-1-yl)methanethione
CAS 840515-93-7C21H18ClFN2OS