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Murcko scaffold

Ring system with 3 rings and 24 atoms

72 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
24
Chemicals
72
With full pages
3
Scaffold SMILES

O=C(NCCS(=O)(=O)N1CCc2ccccc2C1)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(NCCS(=O)(=O)N1CCc2ccccc2C1)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 72 chemicals

N-(2-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)ethyl)-3-methoxybenzamide chemical structure, C19H22N2O4S, CAS 899738-93-3
N-(2-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)ethyl)-3-methoxybenzamide
CAS 899738-93-3C19H22N2O4S
N-(2-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)ethyl)-4-fluorobenzamide chemical structure, C18H19FN2O3S, CAS 899739-79-8
N-(2-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)ethyl)-4-fluorobenzamide
CAS 899739-79-8C18H19FN2O3S
N-(2-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)ethyl)-2,4-dimethoxybenzamide chemical structure, C20H24N2O5S, CAS 899980-08-6
N-(2-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)ethyl)-2,4-dimethoxybenzamide
CAS 899980-08-6C20H24N2O5S
N-(2-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)ethyl)-3,4-dimethoxybenzamide chemical structure, C20H24N2O5S, CAS 899739-91-4
N-(2-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)ethyl)-3,4-dimethoxybenzamide
CAS 899739-91-4C20H24N2O5S
N-(2-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)ethyl)-3,5-dimethylbenzamide chemical structure, C20H24N2O3S, CAS 922115-09-1
N-(2-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)ethyl)-3,5-dimethylbenzamide
CAS 922115-09-1C20H24N2O3S
N-(2-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)ethyl)-2,3-dimethoxybenzamide chemical structure, C20H24N2O5S, CAS 921897-65-6
N-(2-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)ethyl)-2,3-dimethoxybenzamide
CAS 921897-65-6C20H24N2O5S
N-(2-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)ethyl)-3,4,5-trimethoxybenzamide chemical structure, C21H26N2O6S, CAS 923106-82-5
N-(2-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)ethyl)-3,4,5-trimethoxybenzamide
CAS 923106-82-5C21H26N2O6S
2-Fluoro-N-[2-(1,2,3,4-tetrahydroisoquinoline-2-sulfonyl)ethyl]benzamide chemical structure, C18H19FN2O3S, CAS 922087-44-3
2-Fluoro-N-[2-(1,2,3,4-tetrahydroisoquinoline-2-sulfonyl)ethyl]benzamide
CAS 922087-44-3C18H19FN2O3S
N-(2-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)ethyl)-3-fluorobenzamide chemical structure, C18H19FN2O3S, CAS 922036-23-5
N-(2-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)ethyl)-3-fluorobenzamide
CAS 922036-23-5C18H19FN2O3S
N-(2-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)ethyl)-2,6-difluorobenzamide chemical structure, C18H18F2N2O3S, CAS 922036-26-8
N-(2-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)ethyl)-2,6-difluorobenzamide
CAS 922036-26-8C18H18F2N2O3S
N-(2-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)ethyl)-3,4-difluorobenzamide chemical structure, C18H18F2N2O3S, CAS 922115-18-2
N-(2-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)ethyl)-3,4-difluorobenzamide
CAS 922115-18-2C18H18F2N2O3S
2-Chloro-N-(2-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)ethyl)-6-fluorobenzamide chemical structure, C18H18ClFN2O3S, CAS 922036-29-1
2-Chloro-N-(2-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)ethyl)-6-fluorobenzamide
CAS 922036-29-1C18H18ClFN2O3S
N-(2-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)ethyl)-2-(trifluoromethyl)benzamide chemical structure, C19H19F3N2O3S, CAS 921897-80-5
N-(2-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)ethyl)-2-(trifluoromethyl)benzamide
CAS 921897-80-5C19H19F3N2O3S
N-(2-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)ethyl)-3-(trifluoromethyl)benzamide chemical structure, C19H19F3N2O3S, CAS 922087-54-5
N-(2-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)ethyl)-3-(trifluoromethyl)benzamide
CAS 922087-54-5C19H19F3N2O3S
N-[2-(1,2,3,4-Tetrahydroisoquinoline-2-sulfonyl)ethyl]-4-(trifluoromethyl)benzamide chemical structure, C19H19F3N2O3S, CAS 922036-38-2
N-[2-(1,2,3,4-Tetrahydroisoquinoline-2-sulfonyl)ethyl]-4-(trifluoromethyl)benzamide
CAS 922036-38-2C19H19F3N2O3S
2,4-Difluoro-N-[2-(1,2,3,4-tetrahydroisoquinoline-2-sulfonyl)ethyl]benzamide chemical structure, C18H18F2N2O3S, CAS 921925-20-4
2,4-Difluoro-N-[2-(1,2,3,4-tetrahydroisoquinoline-2-sulfonyl)ethyl]benzamide
CAS 921925-20-4C18H18F2N2O3S
4-Butoxy-N-(2-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)ethyl)benzamide chemical structure, C22H28N2O4S, CAS 922115-12-6
4-Butoxy-N-(2-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)ethyl)benzamide
CAS 922115-12-6C22H28N2O4S
5-Chloro-N-(2-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)ethyl)-2-methoxybenzamide chemical structure, C19H21ClN2O4S, CAS 921897-74-7
5-Chloro-N-(2-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)ethyl)-2-methoxybenzamide
CAS 921897-74-7C19H21ClN2O4S
N-(2-((6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)ethyl)benzamide chemical structure, C20H24N2O5S, CAS 922120-36-3
N-(2-((6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)ethyl)benzamide
CAS 922120-36-3C20H24N2O5S
N-(2-((6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)ethyl)-2-methylbenzamide chemical structure, C21H26N2O5S, CAS 922014-31-1
N-(2-((6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)ethyl)-2-methylbenzamide
CAS 922014-31-1C21H26N2O5S
N-(2-((6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)ethyl)-3-methylbenzamide chemical structure, C21H26N2O5S, CAS 921926-75-2
N-(2-((6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)ethyl)-3-methylbenzamide
CAS 921926-75-2C21H26N2O5S
N-{2-[(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)sulfonyl]ethyl}-4-methylbenzamide chemical structure, C21H26N2O5S, CAS 922066-68-0
N-{2-[(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)sulfonyl]ethyl}-4-methylbenzamide
CAS 922066-68-0C21H26N2O5S
N-(2-((6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)ethyl)-3,4-dimethylbenzamide chemical structure, C22H28N2O5S, CAS 922014-34-4
N-(2-((6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)ethyl)-3,4-dimethylbenzamide
CAS 922014-34-4C22H28N2O5S
4-(tert-Butyl)-N-(2-((6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)ethyl)benzamide chemical structure, C24H32N2O5S, CAS 921926-78-5
4-(tert-Butyl)-N-(2-((6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)ethyl)benzamide
CAS 921926-78-5C24H32N2O5S