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Murcko scaffold

2-[4-(Oxolane-2-carbonyl)piperazin-1-yl]-N-phenylacetamide scaffold

15 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
23
Chemicals
15
With full pages
6
Scaffold SMILES

O=C(CN1CCN(C(=O)C2CCCO2)CC1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2-[4-(Oxolane-2-carbonyl)piperazin-1-yl]-N-phenylacetamide page
Murcko scaffold O=C(CN1CCN(C(=O)C2CCCO2)CC1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 15 of 15 chemicals

N-(3,4-Dimethylphenyl)-2-[4-(oxolane-2-carbonyl)piperazin-1-yl]acetamide chemical structure, C19H27N3O3, CAS 904749-29-7
N-(3,4-Dimethylphenyl)-2-[4-(oxolane-2-carbonyl)piperazin-1-yl]acetamide
CAS 904749-29-7C19H27N3O3
N-(4-Fluorophenyl)-2-[4-(oxolane-2-carbonyl)piperazin-1-yl]acetamide chemical structure, C17H22FN3O3, CAS 904753-36-2
N-(4-Fluorophenyl)-2-[4-(oxolane-2-carbonyl)piperazin-1-yl]acetamide
CAS 904753-36-2C17H22FN3O3
2-[4-(Oxolane-2-carbonyl)piperazin-1-yl]-N-(4-propan-2-ylphenyl)acetamide chemical structure, C20H29N3O3, CAS 904752-68-7
2-[4-(Oxolane-2-carbonyl)piperazin-1-yl]-N-(4-propan-2-ylphenyl)acetamide
CAS 904752-68-7C20H29N3O3
N-(2,6-Diethylphenyl)-2-[4-(oxolane-2-carbonyl)piperazin-1-yl]acetamide chemical structure, C21H31N3O3, CAS 904752-56-3
N-(2,6-Diethylphenyl)-2-[4-(oxolane-2-carbonyl)piperazin-1-yl]acetamide
CAS 904752-56-3C21H31N3O3
2-[4-(Oxolane-2-carbonyl)piperazin-1-yl]-N-[3-(trifluoromethyl)phenyl]acetamide chemical structure, C18H22F3N3O3, CAS 904749-72-0
2-[4-(Oxolane-2-carbonyl)piperazin-1-yl]-N-[3-(trifluoromethyl)phenyl]acetamide
CAS 904749-72-0C18H22F3N3O3
N-(2,3-Dimethylphenyl)-2-[4-(oxolane-2-carbonyl)piperazin-1-yl]acetamide chemical structure, C19H27N3O3, CAS 904752-06-3
N-(2,3-Dimethylphenyl)-2-[4-(oxolane-2-carbonyl)piperazin-1-yl]acetamide
CAS 904752-06-3C19H27N3O3
N-(3,5-Dichlorophenyl)-2-[4-(oxolane-2-carbonyl)piperazin-1-yl]acetamide chemical structure, C17H21Cl2N3O3, CAS 904752-29-0
N-(3,5-Dichlorophenyl)-2-[4-(oxolane-2-carbonyl)piperazin-1-yl]acetamide
CAS 904752-29-0C17H21Cl2N3O3
N-(3,4-Dichlorophenyl)-2-[4-(oxolane-2-carbonyl)piperazin-1-yl]acetamide chemical structure, C17H21Cl2N3O3, CAS 904752-35-8
N-(3,4-Dichlorophenyl)-2-[4-(oxolane-2-carbonyl)piperazin-1-yl]acetamide
CAS 904752-35-8C17H21Cl2N3O3
N-(2-Methoxyphenyl)-2-[4-(oxolane-2-carbonyl)piperazin-1-yl]acetamide chemical structure, C18H25N3O4, CAS 904752-41-6
N-(2-Methoxyphenyl)-2-[4-(oxolane-2-carbonyl)piperazin-1-yl]acetamide
CAS 904752-41-6C18H25N3O4
N-(2,4-Dimethoxyphenyl)-2-[4-(oxolane-2-carbonyl)piperazin-1-yl]acetamide chemical structure, C19H27N3O5, CAS 904752-50-7
N-(2,4-Dimethoxyphenyl)-2-[4-(oxolane-2-carbonyl)piperazin-1-yl]acetamide
CAS 904752-50-7C19H27N3O5
N-(4-Chloro-2,5-dimethoxyphenyl)-2-[4-(oxolane-2-carbonyl)piperazin-1-yl]acetamide chemical structure, C19H26ClN3O5, CAS 904752-47-2
N-(4-Chloro-2,5-dimethoxyphenyl)-2-[4-(oxolane-2-carbonyl)piperazin-1-yl]acetamide
CAS 904752-47-2C19H26ClN3O5
N-(2,4-Difluorophenyl)-2-[4-(oxolane-2-carbonyl)piperazin-1-yl]acetamide chemical structure, C17H21F2N3O3, CAS 904749-33-3
N-(2,4-Difluorophenyl)-2-[4-(oxolane-2-carbonyl)piperazin-1-yl]acetamide
CAS 904749-33-3C17H21F2N3O3
2-[4-(Oxolane-2-carbonyl)piperazin-1-yl]-N-phenylacetamide chemical structure, C17H23N3O3, CAS 904753-52-2
2-[4-(Oxolane-2-carbonyl)piperazin-1-yl]-N-phenylacetamide
CAS 904753-52-2C17H23N3O3
2-[4-(Oxolane-2-carbonyl)piperazin-1-yl]-N-(2,4,5-trichlorophenyl)acetamide chemical structure, C17H20Cl3N3O3, CAS 904749-35-5
2-[4-(Oxolane-2-carbonyl)piperazin-1-yl]-N-(2,4,5-trichlorophenyl)acetamide
CAS 904749-35-5C17H20Cl3N3O3
N-(2-Cyanophenyl)-2-[4-(oxolane-2-carbonyl)piperazin-1-yl]acetamide chemical structure, C18H22N4O3, CAS 2726664-16-8
N-(2-Cyanophenyl)-2-[4-(oxolane-2-carbonyl)piperazin-1-yl]acetamide
CAS 2726664-16-8C18H22N4O3