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Murcko scaffold

Ring system with 3 rings and 23 atoms

37 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
23
Chemicals
37
With full pages
4
Scaffold SMILES

O=C1NC(=O)C(Cc2ccc(OCCc3ccccn3)cc2)S1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1NC(=O)C(Cc2ccc(OCCc3ccccn3)cc2)S1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 37 of 37 chemicals

Pioglitazone chemical structure, C19H20N2O3S, CAS 111025-46-8
Pioglitazone
CAS 111025-46-8C19H20N2O3S
Pioglitazone hydrochloride chemical structure, C19H21ClN2O3S, CAS 112529-15-4
Pioglitazone hydrochloride
CAS 112529-15-4C19H21ClN2O3S
Leriglitazone chemical structure, C19H20N2O4S, CAS 146062-44-4
Leriglitazone
CAS 146062-44-4C19H20N2O4S
Ketopioglitazone chemical structure, C19H18N2O4S, CAS 146062-45-5
Ketopioglitazone
CAS 146062-45-5C19H18N2O4S
Metformin hydrochloride, pioglitazone hydrochloride chemical structure, C23H33Cl2N7O3S, CAS 737811-27-7
Metformin hydrochloride, pioglitazone hydrochloride
CAS 737811-27-7C23H33Cl2N7O3S
5-(4-(2-(5-Ethylpyridin-2-yl)-2-hydroxyethoxy)benzyl)thiazolidine-2,4-dione chemical structure, C19H20N2O4S, CAS 101931-00-4
5-(4-(2-(5-Ethylpyridin-2-yl)-2-hydroxyethoxy)benzyl)thiazolidine-2,4-dione
CAS 101931-00-4C19H20N2O4S
Carboxy pioglitazone (M-V) chemical structure, C19H18N2O5S, CAS 146062-48-8
Carboxy pioglitazone (M-V)
CAS 146062-48-8C19H18N2O5S
5-(4-(2-(5-(1-(Methoxymethoxy)ethyl)pyridin-2-yl)ethoxy)benzyl)thiazolidine-2,4-dione chemical structure, C21H24N2O5S, CAS 184766-39-0
5-(4-(2-(5-(1-(Methoxymethoxy)ethyl)pyridin-2-yl)ethoxy)benzyl)thiazolidine-2,4-dione
CAS 184766-39-0C21H24N2O5S
Pioglitazone N-oxide chemical structure, C19H20N2O4S, CAS 145350-09-0
Pioglitazone N-oxide
CAS 145350-09-0C19H20N2O4S
5-(4-(2-Chloro-2-(5-ethylpyridin-2-yl)ethoxy)benzyl)thiazolidine-2,4-dione chemical structure, C19H19ClN2O3S, CAS 646519-88-2
5-(4-(2-Chloro-2-(5-ethylpyridin-2-yl)ethoxy)benzyl)thiazolidine-2,4-dione
CAS 646519-88-2C19H19ClN2O3S
5-[[4-[2-(3-Methyl-2-pyridinyl)ethoxy]phenyl] methyl]-2,4-thiazolidinedione chemical structure, C18H18N2O3S, CAS 105355-33-7
5-[[4-[2-(3-Methyl-2-pyridinyl)ethoxy]phenyl] methyl]-2,4-thiazolidinedione
CAS 105355-33-7C18H18N2O3S
Pioglitazone sodium chemical structure, C19H19N2NaO3S, CAS 105390-47-4
Pioglitazone sodium
CAS 105390-47-4C19H19N2NaO3S
Pioglitazone-d4 chemical structure, C19H20N2O3S, CAS 1134163-29-3
Pioglitazone-d4
CAS 1134163-29-3C19H20N2O3S
Pioglitazone-d4 (major) chemical structure, C19H20N2O3S, CAS 1134163-31-7
Pioglitazone-d4 (major)
CAS 1134163-31-7C19H20N2O3S
5-(4-(2-(5-Ethylpyridin-2-yl)ethoxy)benzyl)thiazolidine-2,4-dione-5-d chemical structure, C19H20N2O3S, CAS 1134163-24-8
5-(4-(2-(5-Ethylpyridin-2-yl)ethoxy)benzyl)thiazolidine-2,4-dione-5-d
CAS 1134163-24-8C19H20N2O3S
Pioglitazone, (S)- chemical structure, C19H20N2O3S, CAS 959687-66-2
Pioglitazone, (S)-
CAS 959687-66-2C19H20N2O3S
Pioglitazone, (R)- chemical structure, C19H20N2O3S, CAS 959687-65-1
Pioglitazone, (R)-
CAS 959687-65-1C19H20N2O3S
5-Desethyl 5-carboxy pioglitazone chemical structure, C18H16N2O5S, CAS 186751-40-6
5-Desethyl 5-carboxy pioglitazone
CAS 186751-40-6C18H16N2O5S
Keto Pioglitazone-d4 (M-III-d4) chemical structure, C19H18N2O4S, CAS 1185033-84-4
Keto Pioglitazone-d4 (M-III-d4)
CAS 1185033-84-4C19H18N2O4S
Hydroxy pioglitazone-d4 (M-IV) chemical structure, C19H20N2O4S, CAS 1188263-49-1
Hydroxy pioglitazone-d4 (M-IV)
CAS 1188263-49-1C19H20N2O4S
Keto pioglitazone-d4 (M-III) chemical structure, C19H18N2O4S, CAS 1215370-26-5
Keto pioglitazone-d4 (M-III)
CAS 1215370-26-5C19H18N2O4S
Hydroxy pioglitazone-D5 (major) (M-IV) chemical structure, C19H20N2O4S, CAS 1189445-29-1
Hydroxy pioglitazone-D5 (major) (M-IV)
CAS 1189445-29-1C19H20N2O4S
5-((4-(2-(5-Ethyl-2-pyridinyl)ethoxy)phenyl)methyl)-5-hydroxy-2,4-thiazolidinedione chemical structure, C19H20N2O4S, CAS 625853-74-9
5-((4-(2-(5-Ethyl-2-pyridinyl)ethoxy)phenyl)methyl)-5-hydroxy-2,4-thiazolidinedione
CAS 625853-74-9C19H20N2O4S
Deuteropioglitazone, (5R)- chemical structure, C19H20N2O3S, CAS 1259828-75-5
Deuteropioglitazone, (5R)-
CAS 1259828-75-5C19H20N2O3S