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Murcko scaffold

Ring system with 4 rings and 26 atoms

17 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
26
Chemicals
17
With full pages
7
Scaffold SMILES

O=C(CN1C(=O)c2ccccc2C1=O)N1CCN(c2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CN1C(=O)c2ccccc2C1=O)N1CCN(c2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 17 of 17 chemicals

2-[2-[4-(4-Methoxyphenyl)piperazin-1-yl]-2-oxoethyl]isoindole-1,3-dione chemical structure, C21H21N3O4, CAS 450383-43-4
2-[2-[4-(4-Methoxyphenyl)piperazin-1-yl]-2-oxoethyl]isoindole-1,3-dione
CAS 450383-43-4C21H21N3O4
2-(2-Oxo-2-(4-(o-tolyl)piperazin-1-yl)ethyl)isoindoline-1,3-dione chemical structure, C21H21N3O3, CAS 53646-61-0
2-(2-Oxo-2-(4-(o-tolyl)piperazin-1-yl)ethyl)isoindoline-1,3-dione
CAS 53646-61-0C21H21N3O3
2-[2-Oxo-2-(4-p-tolyl-piperazin-1-yl)-ethyl]-isoindole-1,3-dione chemical structure, C21H21N3O3, CAS 53646-59-6
2-[2-Oxo-2-(4-p-tolyl-piperazin-1-yl)-ethyl]-isoindole-1,3-dione
CAS 53646-59-6C21H21N3O3
2-{2-[4-(4-Fluorophenyl)piperazin-1-yl]-2-oxoethyl}-1H-isoindole-1,3(2H)-dione chemical structure, C20H18FN3O3, CAS 53646-64-3
2-{2-[4-(4-Fluorophenyl)piperazin-1-yl]-2-oxoethyl}-1H-isoindole-1,3(2H)-dione
CAS 53646-64-3C20H18FN3O3
2-[2-[4-(2,3-Dimethylphenyl)piperazin-1-yl]-2-oxoethyl]isoindole-1,3-dione chemical structure, C22H23N3O3, CAS 349637-03-2
2-[2-[4-(2,3-Dimethylphenyl)piperazin-1-yl]-2-oxoethyl]isoindole-1,3-dione
CAS 349637-03-2C22H23N3O3
2-[2-[4-(3-Chlorophenyl)piperazin-1-yl]-2-oxoethyl]isoindole-1,3-dione chemical structure, C20H18ClN3O3, CAS 349086-62-0
2-[2-[4-(3-Chlorophenyl)piperazin-1-yl]-2-oxoethyl]isoindole-1,3-dione
CAS 349086-62-0C20H18ClN3O3
2-[2-[4-(2-Methoxyphenyl)piperazin-1-yl]-2-oxoethyl]isoindole-1,3-dione chemical structure, C21H21N3O4, CAS 342779-89-9
2-[2-[4-(2-Methoxyphenyl)piperazin-1-yl]-2-oxoethyl]isoindole-1,3-dione
CAS 342779-89-9C21H21N3O4
2-(2-(4-(2-Chlorophenyl)piperazin-1-yl)-2-oxoethyl)isoindoline-1,3-dione chemical structure, C20H18ClN3O3, CAS 419539-48-3
2-(2-(4-(2-Chlorophenyl)piperazin-1-yl)-2-oxoethyl)isoindoline-1,3-dione
CAS 419539-48-3C20H18ClN3O3
2-[2-[4-(2-Methoxyphenyl)piperazin-1-yl]-2-oxoethyl]-4-nitroisoindole-1,3-dione chemical structure, C21H20N4O6, CAS 667404-14-0
2-[2-[4-(2-Methoxyphenyl)piperazin-1-yl]-2-oxoethyl]-4-nitroisoindole-1,3-dione
CAS 667404-14-0C21H20N4O6
2-[2-[4-(4-Fluorophenyl)piperazin-1-yl]-2-oxoethyl]-4-nitroisoindole-1,3-dione chemical structure, C20H17FN4O5, CAS 690963-13-4
2-[2-[4-(4-Fluorophenyl)piperazin-1-yl]-2-oxoethyl]-4-nitroisoindole-1,3-dione
CAS 690963-13-4C20H17FN4O5
2-[1-Oxo-1-(4-phenylpiperazin-1-yl)propan-2-yl]isoindole-1,3-dione chemical structure, C21H21N3O3, CAS 419539-09-6
2-[1-Oxo-1-(4-phenylpiperazin-1-yl)propan-2-yl]isoindole-1,3-dione
CAS 419539-09-6C21H21N3O3
2-[1-Methyl-2-oxo-2-(4-p-tolyl-piperazin-1-yl)-ethyl]-isoindole-1,3-dione chemical structure, C22H23N3O3, CAS 333412-20-7
2-[1-Methyl-2-oxo-2-(4-p-tolyl-piperazin-1-yl)-ethyl]-isoindole-1,3-dione
CAS 333412-20-7C22H23N3O3
2-{1-[4-(4-Fluorophenyl)piperazin-1-yl]-1-oxopropan-2-yl}-1H-isoindole-1,3(2H)-dione chemical structure, C21H20FN3O3, CAS 433967-39-6
2-{1-[4-(4-Fluorophenyl)piperazin-1-yl]-1-oxopropan-2-yl}-1H-isoindole-1,3(2H)-dione
CAS 433967-39-6C21H20FN3O3
2-[1-[4-(3-Methoxyphenyl)piperazin-1-yl]-1-oxopropan-2-yl]isoindole-1,3-dione chemical structure, C22H23N3O4, CAS 510764-08-6
2-[1-[4-(3-Methoxyphenyl)piperazin-1-yl]-1-oxopropan-2-yl]isoindole-1,3-dione
CAS 510764-08-6C22H23N3O4
2-[1-[4-(4-Methoxyphenyl)piperazin-1-yl]-1-oxopropan-2-yl]isoindole-1,3-dione chemical structure, C22H23N3O4, CAS 510764-09-7
2-[1-[4-(4-Methoxyphenyl)piperazin-1-yl]-1-oxopropan-2-yl]isoindole-1,3-dione
CAS 510764-09-7C22H23N3O4
2-[1-[4-(2-Fluorophenyl)piperazin-1-yl]-1-oxopropan-2-yl]isoindole-1,3-dione chemical structure, C21H20FN3O3, CAS 510764-05-3
2-[1-[4-(2-Fluorophenyl)piperazin-1-yl]-1-oxopropan-2-yl]isoindole-1,3-dione
CAS 510764-05-3C21H20FN3O3
2-[1-[4-(2-Chlorophenyl)piperazin-1-yl]-1-oxopropan-2-yl]isoindole-1,3-dione chemical structure, C21H20ClN3O3, CAS 419540-60-6
2-[1-[4-(2-Chlorophenyl)piperazin-1-yl]-1-oxopropan-2-yl]isoindole-1,3-dione
CAS 419540-60-6C21H20ClN3O3