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Murcko scaffold

Ring system with 4 rings and 24 atoms

10 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
24
Chemicals
10
With full pages
1
Scaffold SMILES

O=C(Nc1cc2c(s1)CCCC2)c1ccc(-c2ccccc2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1cc2c(s1)CCCC2)c1ccc(-c2ccccc2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 10 of 10 chemicals

2-[(4-Phenylbenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C22H20N2O2S, CAS 313662-65-6
2-[(4-Phenylbenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 313662-65-6C22H20N2O2S
N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-4-phenylbenzamide chemical structure, C22H18N2OS, CAS 296266-10-9
N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-4-phenylbenzamide
CAS 296266-10-9C22H18N2OS
2-Methoxyethyl 2-[(4-phenylbenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate chemical structure, C25H25NO4S, CAS 514818-96-3
2-Methoxyethyl 2-[(4-phenylbenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
CAS 514818-96-3C25H25NO4S
2-[(Biphenyl-4-ylcarbonyl)amino]-6-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C23H22N2O2S, CAS 302950-12-5
2-[(Biphenyl-4-ylcarbonyl)amino]-6-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 302950-12-5C23H22N2O2S
Methyl 6-(2-methylbutan-2-yl)-2-[(4-phenylbenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate chemical structure, C28H31NO3S, CAS 549489-84-1
Methyl 6-(2-methylbutan-2-yl)-2-[(4-phenylbenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
CAS 549489-84-1C28H31NO3S
Ethyl 6-tert-butyl-2-[(4-phenylbenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate chemical structure, C28H31NO3S, CAS 573997-05-4
Ethyl 6-tert-butyl-2-[(4-phenylbenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
CAS 573997-05-4C28H31NO3S
Methyl 6-methyl-2-[(4-phenylbenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate chemical structure, C24H23NO3S, CAS 448226-90-2
Methyl 6-methyl-2-[(4-phenylbenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
CAS 448226-90-2C24H23NO3S
N-(3-Cyano-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-4-phenylbenzamide chemical structure, C23H20N2OS, CAS 391221-67-3
N-(3-Cyano-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-4-phenylbenzamide
CAS 391221-67-3C23H20N2OS
N-Methyl-2-[(4-phenylbenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C23H22N2O2S, CAS 892976-91-9
N-Methyl-2-[(4-phenylbenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 892976-91-9C23H22N2O2S
2-{[1,1'-Biphenyl]-4-amido}-N,6-dimethyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C24H24N2O2S, CAS 921110-21-6
2-{[1,1'-Biphenyl]-4-amido}-N,6-dimethyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 921110-21-6C24H24N2O2S