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Murcko scaffold

1-Piperazinylpyrazine scaffold

241 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
12
Chemicals
241
With full pages
16
Scaffold SMILES

c1cnc(N2CCNCC2)cn1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-Piperazinylpyrazine page
Murcko scaffold c1cnc(N2CCNCC2)cn1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 241 chemicals

2-Chloro-6-(1-piperazinyl)pyrazine chemical structure, C8H11ClN4, CAS 64022-27-1
2-Chloro-6-(1-piperazinyl)pyrazine
CAS 64022-27-1C8H11ClN4
N(5)-piperazine-amiloride chemical structure, C10H15ClN8O, CAS 127628-91-5
N(5)-piperazine-amiloride
CAS 127628-91-5C10H15ClN8O
MK-212 hydrochloride chemical structure, C8H12Cl2N4, CAS 61655-58-1
MK-212 hydrochloride
CAS 61655-58-1C8H12Cl2N4
1-Piperazinylpyrazine chemical structure, C8H12N4, CAS 34803-68-4
1-Piperazinylpyrazine
CAS 34803-68-4C8H12N4
3-(Piperazin-1-yl)pyrazine-2-carbonitrile chemical structure, C9H11N5, CAS 306935-30-8
3-(Piperazin-1-yl)pyrazine-2-carbonitrile
CAS 306935-30-8C9H11N5
2,5-Dimethyl-3-piperazin-1-ylpyrazine chemical structure, C10H16N4, CAS 59215-42-8
2,5-Dimethyl-3-piperazin-1-ylpyrazine
CAS 59215-42-8C10H16N4
2-Chloro-5-(1-piperazinyl)pyrazine chemical structure, C8H11ClN4, CAS 84445-51-2
2-Chloro-5-(1-piperazinyl)pyrazine
CAS 84445-51-2C8H11ClN4
2-Iodo-5-piperazin-1-ylpyrazine chemical structure, C8H11IN4, CAS 1026956-27-3
2-Iodo-5-piperazin-1-ylpyrazine
CAS 1026956-27-3C8H11IN4
2-Chloro-6-(4-methylpiperazin-1-yl)pyrazine chemical structure, C9H13ClN4, CAS 61655-77-4
2-Chloro-6-(4-methylpiperazin-1-yl)pyrazine
CAS 61655-77-4C9H13ClN4
(R)-2-Chloro-3-(2-methylpiperazin-1-yl)pyrazine chemical structure, C9H13ClN4, CAS 313657-76-0
(R)-2-Chloro-3-(2-methylpiperazin-1-yl)pyrazine
CAS 313657-76-0C9H13ClN4
tert-Butyl 4-(3-chloropyrazin-2-yl)piperazine-1-carboxylate chemical structure, C13H19ClN4O2, CAS 313654-83-0
tert-Butyl 4-(3-chloropyrazin-2-yl)piperazine-1-carboxylate
CAS 313654-83-0C13H19ClN4O2
2-[3-(4-tert-Butoxycarbonyl-1-piperazinyl)-2-pyrazinyloxy]ethanol chemical structure, C15H24N4O4, CAS 313654-84-1
2-[3-(4-tert-Butoxycarbonyl-1-piperazinyl)-2-pyrazinyloxy]ethanol
CAS 313654-84-1C15H24N4O4
2-(Piperazin-1-yl)pyrazine hydrochloride chemical structure, C8H13ClN4, CAS 61655-78-5
2-(Piperazin-1-yl)pyrazine hydrochloride
CAS 61655-78-5C8H13ClN4
6-(4-Methylpiperazin-1-yl)pyrazine-2-carbonitrile chemical structure, C10H13N5, CAS 104169-57-5
6-(4-Methylpiperazin-1-yl)pyrazine-2-carbonitrile
CAS 104169-57-5C10H13N5
4-(6-Chloropyrazin-2-yl)piperazine-1-carbaldehyde chemical structure, C9H11ClN4O, CAS 61655-76-3
4-(6-Chloropyrazin-2-yl)piperazine-1-carbaldehyde
CAS 61655-76-3C9H11ClN4O
5-Chloro-6-(4-methylpiperazin-1-yl)-3-nitropyrazin-2-amine chemical structure, C9H13ClN6O2, CAS 88793-50-4
5-Chloro-6-(4-methylpiperazin-1-yl)-3-nitropyrazin-2-amine
CAS 88793-50-4C9H13ClN6O2
1-[4-(Pyrazin-2-yl)piperazin-1-yl]octan-1-one chemical structure, C16H26N4O, CAS 89007-18-1
1-[4-(Pyrazin-2-yl)piperazin-1-yl]octan-1-one
CAS 89007-18-1C16H26N4O
N-Ethyl-4-(pyrazin-2-yl)piperazine-1-carboxamide chemical structure, C11H17N5O, CAS 89007-29-4
N-Ethyl-4-(pyrazin-2-yl)piperazine-1-carboxamide
CAS 89007-29-4C11H17N5O
N-Methyl-4-(pyrazin-2-yl)piperazine-1-carboxamide chemical structure, C10H15N5O, CAS 89007-30-7
N-Methyl-4-(pyrazin-2-yl)piperazine-1-carboxamide
CAS 89007-30-7C10H15N5O
N-tert-Butyl-4-(pyrazin-2-yl)piperazine-1-carboxamide chemical structure, C13H21N5O, CAS 89007-32-9
N-tert-Butyl-4-(pyrazin-2-yl)piperazine-1-carboxamide
CAS 89007-32-9C13H21N5O
3-(4-Methylpiperazin-1-yl)pyrazine-2-carbonitrile chemical structure, C10H13N5, CAS 90601-43-7
3-(4-Methylpiperazin-1-yl)pyrazine-2-carbonitrile
CAS 90601-43-7C10H13N5
5,6-Dichloro-3-(4-methylpiperazin-1-yl)pyrazine-2-carbonitrile chemical structure, C10H11Cl2N5, CAS 90601-44-8
5,6-Dichloro-3-(4-methylpiperazin-1-yl)pyrazine-2-carbonitrile
CAS 90601-44-8C10H11Cl2N5
N-Methyl-4-(pyrazin-2-yl)piperazine-1-carbothioamide chemical structure, C10H15N5S, CAS 89007-40-9
N-Methyl-4-(pyrazin-2-yl)piperazine-1-carbothioamide
CAS 89007-40-9C10H15N5S
N-Butyl-4-(pyrazin-2-yl)piperazine-1-carbothioamide chemical structure, C13H21N5S, CAS 89007-54-5
N-Butyl-4-(pyrazin-2-yl)piperazine-1-carbothioamide
CAS 89007-54-5C13H21N5S