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Murcko scaffold

Ring system with 4 rings and 22 atoms

840 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
22
Chemicals
840
With full pages
15
Scaffold SMILES

O=C(NC1CCC1)OCC1c2ccccc2-c2ccccc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(NC1CCC1)OCC1c2ccccc2-c2ccccc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 769 to 816 of 840 chemicals

1-(Difluoromethyl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutane-1-carboxylic acid chemical structure, C21H19F2NO4, CAS 2694734-52-4
1-(Difluoromethyl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutane-1-carboxylic acid
CAS 2694734-52-4C21H19F2NO4
(2S)-2-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}butanoic acid chemical structure, C25H28N2O5, CAS 2171196-16-8
(2S)-2-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}butanoic acid
CAS 2171196-16-8C25H28N2O5
(2S,3R)-2-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-3-methoxybutanoic acid chemical structure, C26H30N2O6, CAS 2171207-65-9
(2S,3R)-2-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-3-methoxybutanoic acid
CAS 2171207-65-9C26H30N2O6
2-({[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}methyl)-4-methylpentanoic acid chemical structure, C27H32N2O5, CAS 2172118-68-0
2-({[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}methyl)-4-methylpentanoic acid
CAS 2172118-68-0C27H32N2O5
5-{N-Ethyl-1-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}pentanoic acid chemical structure, C27H32N2O5, CAS 2172003-08-4
5-{N-Ethyl-1-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}pentanoic acid
CAS 2172003-08-4C27H32N2O5
(2S)-3-(Dimethylamino)-2-{[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}propanoic acid chemical structure, C25H29N3O5, CAS 2171160-87-3
(2S)-3-(Dimethylamino)-2-{[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}propanoic acid
CAS 2171160-87-3C25H29N3O5
2-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-(propan-2-yl)acetamido}acetic acid chemical structure, C26H30N2O5, CAS 2172288-74-1
2-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-(propan-2-yl)acetamido}acetic acid
CAS 2172288-74-1C26H30N2O5
2-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-methylacetamido}-2-methylpropanoic acid chemical structure, C26H30N2O5, CAS 2172433-71-3
2-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-methylacetamido}-2-methylpropanoic acid
CAS 2172433-71-3C26H30N2O5
3-({2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}methyl)-4-methylpentanoic acid chemical structure, C28H34N2O5, CAS 2172433-08-6
3-({2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}methyl)-4-methylpentanoic acid
CAS 2172433-08-6C28H34N2O5
3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-1-methanesulfonylcyclobutane-1-carboxylic acid chemical structure, C21H21NO6S, CAS 2763887-03-0
3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-1-methanesulfonylcyclobutane-1-carboxylic acid
CAS 2763887-03-0C21H21NO6S
(9H-Fluoren-9-yl)methyl N-[(1r,3r)-3-(aminomethyl)cyclobutyl]carbamate chemical structure, C20H22N2O2, CAS 2276383-17-4
(9H-Fluoren-9-yl)methyl N-[(1r,3r)-3-(aminomethyl)cyclobutyl]carbamate
CAS 2276383-17-4C20H22N2O2
rac-(9H-Fluoren-9-yl)methyl N-[(1R,2R)-2-hydroxycyclobutyl]carbamate chemical structure, C19H19NO3, CAS 2764000-09-9
rac-(9H-Fluoren-9-yl)methyl N-[(1R,2R)-2-hydroxycyclobutyl]carbamate
CAS 2764000-09-9C19H19NO3
(9H-Fluoren-9-yl)methyl N-cyclobutyl-N-[2-(2-hydroxyethoxy)ethyl]carbamate chemical structure, C23H27NO4, CAS 2764000-54-4
(9H-Fluoren-9-yl)methyl N-cyclobutyl-N-[2-(2-hydroxyethoxy)ethyl]carbamate
CAS 2764000-54-4C23H27NO4
(9H-Fluoren-9-yl)methyl N-[3,3-difluoro-1-(hydroxymethyl)cyclobutyl]carbamate chemical structure, C20H19F2NO3, CAS 2763976-11-8
(9H-Fluoren-9-yl)methyl N-[3,3-difluoro-1-(hydroxymethyl)cyclobutyl]carbamate
CAS 2763976-11-8C20H19F2NO3
rac-(9H-Fluoren-9-yl)methyl N-[(1R,2R)-2-hydroxycyclobutyl]-N-methylcarbamate chemical structure, C20H21NO3, CAS 2763932-03-0
rac-(9H-Fluoren-9-yl)methyl N-[(1R,2R)-2-hydroxycyclobutyl]-N-methylcarbamate
CAS 2763932-03-0C20H21NO3
(9H-Fluoren-9-yl)methyl N-[1-(2-fluoroethyl)-3-hydroxycyclobutyl]carbamate chemical structure, C21H22FNO3, CAS 2763947-50-6
(9H-Fluoren-9-yl)methyl N-[1-(2-fluoroethyl)-3-hydroxycyclobutyl]carbamate
CAS 2763947-50-6C21H22FNO3
rac-(9H-Fluoren-9-yl)methyl N-[(1R,2S)-2-(hydroxymethyl)cyclobutyl]carbamate chemical structure, C20H21NO3, CAS 2763955-69-5
rac-(9H-Fluoren-9-yl)methyl N-[(1R,2S)-2-(hydroxymethyl)cyclobutyl]carbamate
CAS 2763955-69-5C20H21NO3
(9H-Fluoren-9-yl)methyl N-(3-hydroxycyclobutyl)-N-methylcarbamate chemical structure, C20H21NO3, CAS 2763886-52-6
(9H-Fluoren-9-yl)methyl N-(3-hydroxycyclobutyl)-N-methylcarbamate
CAS 2763886-52-6C20H21NO3
Methyl 1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-(hydroxymethyl)cyclobutane-1-carboxylate chemical structure, C22H23NO5, CAS 2763888-54-4
Methyl 1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-(hydroxymethyl)cyclobutane-1-carboxylate
CAS 2763888-54-4C22H23NO5
rac-(9H-Fluoren-9-yl)methyl N-[(1R,2S)-2-hydroxycyclobutyl]carbamate chemical structure, C19H19NO3, CAS 2763939-18-8
rac-(9H-Fluoren-9-yl)methyl N-[(1R,2S)-2-hydroxycyclobutyl]carbamate
CAS 2763939-18-8C19H19NO3
(9H-Fluoren-9-yl)methyl N-[(1S,2S)-2-hydroxycyclobutyl]carbamate chemical structure, C19H19NO3, CAS 2763891-68-3
(9H-Fluoren-9-yl)methyl N-[(1S,2S)-2-hydroxycyclobutyl]carbamate
CAS 2763891-68-3C19H19NO3
rac-(9H-Fluoren-9-yl)methyl N-[(1R,2S)-2-hydroxy-3,3-dimethylcyclobutyl]carbamate chemical structure, C21H23NO3, CAS 2764019-59-0
rac-(9H-Fluoren-9-yl)methyl N-[(1R,2S)-2-hydroxy-3,3-dimethylcyclobutyl]carbamate
CAS 2764019-59-0C21H23NO3
(9H-Fluoren-9-yl)methyl N-[(1r,3s)-3-ethyl-3-hydroxycyclobutyl]carbamate chemical structure, C21H23NO3, CAS 2763885-62-5
(9H-Fluoren-9-yl)methyl N-[(1r,3s)-3-ethyl-3-hydroxycyclobutyl]carbamate
CAS 2763885-62-5C21H23NO3
(9H-Fluoren-9-yl)methyl N-[3-(2-hydroxypropan-2-yl)cyclobutyl]carbamate chemical structure, C22H25NO3, CAS 2301973-28-2
(9H-Fluoren-9-yl)methyl N-[3-(2-hydroxypropan-2-yl)cyclobutyl]carbamate
CAS 2301973-28-2C22H25NO3