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Murcko scaffold

Ring system with 4 rings and 22 atoms

840 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
22
Chemicals
840
With full pages
15
Scaffold SMILES

O=C(NC1CCC1)OCC1c2ccccc2-c2ccccc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(NC1CCC1)OCC1c2ccccc2-c2ccccc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 721 to 768 of 840 chemicals

(3R)-3-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}pentanoic acid chemical structure, C26H30N2O5, CAS 2171226-44-9
(3R)-3-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}pentanoic acid
CAS 2171226-44-9C26H30N2O5
4-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}butanoic acid chemical structure, C25H28N2O5, CAS 2172603-99-3
4-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}butanoic acid
CAS 2172603-99-3C25H28N2O5
2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-4-methoxy-4-methylpentanoic acid chemical structure, C27H32N2O6, CAS 2171785-42-3
2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-4-methoxy-4-methylpentanoic acid
CAS 2171785-42-3C27H32N2O6
2-{1-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-[2-(methylsulfanyl)ethyl]formamido}acetic acid chemical structure, C25H28N2O5S, CAS 2171852-74-5
2-{1-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-[2-(methylsulfanyl)ethyl]formamido}acetic acid
CAS 2171852-74-5C25H28N2O5S
2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-(methylsulfanyl)cyclobutyl]acetic acid chemical structure, C22H23NO4S, CAS 2171971-00-7
2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-(methylsulfanyl)cyclobutyl]acetic acid
CAS 2171971-00-7C22H23NO4S
2-({2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-methylacetamido}oxy)acetic acid chemical structure, C24H26N2O6, CAS 2172161-59-8
2-({2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-methylacetamido}oxy)acetic acid
CAS 2172161-59-8C24H26N2O6
(3S)-3-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}butanoic acid chemical structure, C25H28N2O5, CAS 2171248-08-9
(3S)-3-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}butanoic acid
CAS 2171248-08-9C25H28N2O5
2-[(2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}ethyl)sulfanyl]acetic acid chemical structure, C24H26N2O5S, CAS 2172281-07-9
2-[(2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}ethyl)sulfanyl]acetic acid
CAS 2172281-07-9C24H26N2O5S
(2S)-2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-4-methoxy-4-oxobutanoic acid chemical structure, C26H28N2O7, CAS 2171191-36-7
(2S)-2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-4-methoxy-4-oxobutanoic acid
CAS 2171191-36-7C26H28N2O7
4-{[3-({[(tert-Butoxy)carbonyl]amino}methyl)cyclobutyl]({[(9H-fluoren-9-yl)methoxy]carbonyl})amino}butanoic acid chemical structure, C29H36N2O6, CAS 2138091-59-3
4-{[3-({[(tert-Butoxy)carbonyl]amino}methyl)cyclobutyl]({[(9H-fluoren-9-yl)methoxy]carbonyl})amino}butanoic acid
CAS 2138091-59-3C29H36N2O6
(2S)-2-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-4-methoxy-4-oxobutanoic acid chemical structure, C25H26N2O7, CAS 2171207-82-0
(2S)-2-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-4-methoxy-4-oxobutanoic acid
CAS 2171207-82-0C25H26N2O7
(2R)-2-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-4-methoxy-4-oxobutanoic acid chemical structure, C26H28N2O7, CAS 2171159-15-0
(2R)-2-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-4-methoxy-4-oxobutanoic acid
CAS 2171159-15-0C26H28N2O7
(2R)-2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-5-methoxy-5-oxopentanoic acid chemical structure, C26H28N2O7, CAS 2171173-38-7
(2R)-2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-5-methoxy-5-oxopentanoic acid
CAS 2171173-38-7C26H28N2O7
(2S)-2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-4-methoxy-4-oxobutanoic acid chemical structure, C25H26N2O7, CAS 2171194-98-0
(2S)-2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-4-methoxy-4-oxobutanoic acid
CAS 2171194-98-0C25H26N2O7
4-{[3-(2-{[(tert-Butoxy)carbonyl]amino}ethyl)cyclobutyl]({[(9H-fluoren-9-yl)methoxy]carbonyl})amino}butanoic acid chemical structure, C30H38N2O6, CAS 2138053-18-4
4-{[3-(2-{[(tert-Butoxy)carbonyl]amino}ethyl)cyclobutyl]({[(9H-fluoren-9-yl)methoxy]carbonyl})amino}butanoic acid
CAS 2138053-18-4C30H38N2O6
2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-2-methylpropanoic acid chemical structure, C24H26N2O5, CAS 2172524-16-0
2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-2-methylpropanoic acid
CAS 2172524-16-0C24H26N2O5
6-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}hexanoic acid chemical structure, C27H32N2O5, CAS 2172215-35-7
6-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}hexanoic acid
CAS 2172215-35-7C27H32N2O5
2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-2-methylbutanoic acid chemical structure, C25H28N2O5, CAS 2649059-66-3
2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-2-methylbutanoic acid
CAS 2649059-66-3C25H28N2O5
2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-3,3-dimethylbutanoic acid chemical structure, C26H30N2O5, CAS 2171685-14-4
2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-3,3-dimethylbutanoic acid
CAS 2171685-14-4C26H30N2O5
7-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}heptanoic acid chemical structure, C28H34N2O5, CAS 2172291-55-1
7-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}heptanoic acid
CAS 2172291-55-1C28H34N2O5
2-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-(2-methoxyethyl)acetamido}acetic acid chemical structure, C26H30N2O6, CAS 2171804-25-2
2-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-(2-methoxyethyl)acetamido}acetic acid
CAS 2171804-25-2C26H30N2O6
4-{1-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-(propan-2-yl)formamido}butanoic acid chemical structure, C27H32N2O5, CAS 2172429-91-1
4-{1-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-(propan-2-yl)formamido}butanoic acid
CAS 2172429-91-1C27H32N2O5
2-({2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}oxy)propanoic acid chemical structure, C24H26N2O6, CAS 2172043-81-9
2-({2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}oxy)propanoic acid
CAS 2172043-81-9C24H26N2O6
2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-4-methylhexanoic acid chemical structure, C27H32N2O5, CAS 2171582-04-8
2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-4-methylhexanoic acid
CAS 2171582-04-8C27H32N2O5