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Murcko scaffold

Ring system with 4 rings and 22 atoms

840 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
22
Chemicals
840
With full pages
15
Scaffold SMILES

O=C(NC1CCC1)OCC1c2ccccc2-c2ccccc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(NC1CCC1)OCC1c2ccccc2-c2ccccc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 840 chemicals

1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutane-1-carboxylic acid chemical structure, C20H19NO4, CAS 885951-77-9
1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutane-1-carboxylic acid
CAS 885951-77-9C20H19NO4
(1S,3R)-3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2,2-dimethylcyclobutane-1-carboxylic acid chemical structure, C22H23NO4, CAS 188918-45-8
(1S,3R)-3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2,2-dimethylcyclobutane-1-carboxylic acid
CAS 188918-45-8C22H23NO4
(9H-Fluoren-9-yl)methyl (3-hydroxycyclobutyl)carbamate chemical structure, C19H19NO3, CAS 2763891-70-7
(9H-Fluoren-9-yl)methyl (3-hydroxycyclobutyl)carbamate
CAS 2763891-70-7C19H19NO3
2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetic acid chemical structure, C21H21NO4, CAS 1199775-14-8
2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetic acid
CAS 1199775-14-8C21H21NO4
(9H-Fluoren-9-yl)methyl N-cyclobutyl-N-(3-hydroxypropyl)carbamate chemical structure, C22H25NO3, CAS 1600303-05-6
(9H-Fluoren-9-yl)methyl N-cyclobutyl-N-(3-hydroxypropyl)carbamate
CAS 1600303-05-6C22H25NO3
(9H-Fluoren-9-yl)methyl N-cyclobutyl-N-(2-hydroxyethyl)carbamate chemical structure, C21H23NO3, CAS 1593773-91-1
(9H-Fluoren-9-yl)methyl N-cyclobutyl-N-(2-hydroxyethyl)carbamate
CAS 1593773-91-1C21H23NO3
1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-methylcyclobutane-1-carboxylic acid chemical structure, C21H21NO4, CAS 1699709-29-9
1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-methylcyclobutane-1-carboxylic acid
CAS 1699709-29-9C21H21NO4
1-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-methylcyclobutane-1-carboxylic acid chemical structure, C22H23NO4, CAS 1702851-18-0
1-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-methylcyclobutane-1-carboxylic acid
CAS 1702851-18-0C22H23NO4
1-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)cyclobutane-1-carboxylic acid chemical structure, C21H21NO4, CAS 1700368-07-5
1-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)cyclobutane-1-carboxylic acid
CAS 1700368-07-5C21H21NO4
1-(N-Fmoc-N-ethyl-amino)-cyclobutanecarboxylic Acid chemical structure, C22H23NO4, CAS 1692710-13-6
1-(N-Fmoc-N-ethyl-amino)-cyclobutanecarboxylic Acid
CAS 1692710-13-6C22H23NO4
1-[[(9H-Fluoren-9-ylmethoxy)carbonyl]propylamino]cyclobutanecarboxylic acid chemical structure, C23H25NO4, CAS 1702181-48-3
1-[[(9H-Fluoren-9-ylmethoxy)carbonyl]propylamino]cyclobutanecarboxylic acid
CAS 1702181-48-3C23H25NO4
1-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-methoxycyclobutane-1-carboxylic acid chemical structure, C21H21NO5, CAS 1696791-50-0
1-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-methoxycyclobutane-1-carboxylic acid
CAS 1696791-50-0C21H21NO5
1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}(methyl)amino)-3-methoxycyclobutane-1-carboxylic acid chemical structure, C22H23NO5, CAS 1701640-16-5
1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}(methyl)amino)-3-methoxycyclobutane-1-carboxylic acid
CAS 1701640-16-5C22H23NO5
(9H-Fluoren-9-yl)methyl N-(3-hydroxy-2,2-dimethylcyclobutyl)carbamate chemical structure, C21H23NO3, CAS 1593445-74-9
(9H-Fluoren-9-yl)methyl N-(3-hydroxy-2,2-dimethylcyclobutyl)carbamate
CAS 1593445-74-9C21H23NO3
(9H-Fluoren-9-yl)methyl N-[1-(hydroxymethyl)cyclobutyl]carbamate chemical structure, C20H21NO3, CAS 1598504-43-8
(9H-Fluoren-9-yl)methyl N-[1-(hydroxymethyl)cyclobutyl]carbamate
CAS 1598504-43-8C20H21NO3
1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3,3-difluorocyclobutane-1-carboxylic acid chemical structure, C20H17F2NO4, CAS 1936532-04-5
1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3,3-difluorocyclobutane-1-carboxylic acid
CAS 1936532-04-5C20H17F2NO4
3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-(trifluoromethyl)cyclobutane-1-carboxylic acid chemical structure, C21H18F3NO4, CAS 1987261-54-0
3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-(trifluoromethyl)cyclobutane-1-carboxylic acid
CAS 1987261-54-0C21H18F3NO4
(1r,3r)-3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutane-1-carboxylic acid chemical structure, C20H19NO4, CAS 1935557-50-8
(1r,3r)-3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutane-1-carboxylic acid
CAS 1935557-50-8C20H19NO4
(1R,3S)-3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2,2-dimethylcyclobutane-1-carboxylic acid chemical structure, C22H23NO4, CAS 1471195-73-9
(1R,3S)-3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2,2-dimethylcyclobutane-1-carboxylic acid
CAS 1471195-73-9C22H23NO4
1-(9H-Fluoren-9-ylmethoxycarbonylamino)-3,3-dimethyl-cyclobutanecarboxylic acid chemical structure, C22H23NO4, CAS 1936161-54-4
1-(9H-Fluoren-9-ylmethoxycarbonylamino)-3,3-dimethyl-cyclobutanecarboxylic acid
CAS 1936161-54-4C22H23NO4
(9H-Fluoren-9-yl)methyl N-[3-(aminomethyl)-2,2-dimethylcyclobutyl]carbamate chemical structure, C22H26N2O2, CAS 2322705-57-5
(9H-Fluoren-9-yl)methyl N-[3-(aminomethyl)-2,2-dimethylcyclobutyl]carbamate
CAS 2322705-57-5C22H26N2O2
1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2,2-dimethylcyclobutane-1-carboxylic acid chemical structure, C22H23NO4, CAS 1871525-50-6
1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2,2-dimethylcyclobutane-1-carboxylic acid
CAS 1871525-50-6C22H23NO4
3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2,2-dimethylcyclobutane-1-carboxylic acid chemical structure, C22H23NO4, CAS 1936121-52-6
3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2,2-dimethylcyclobutane-1-carboxylic acid
CAS 1936121-52-6C22H23NO4
2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetic acid chemical structure, C21H21NO4, CAS 2137718-93-3
2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetic acid
CAS 2137718-93-3C21H21NO4