Murcko scaffold
2-(Phenylamino)-1-(piperidin-1-yl)ethan-1-one scaffold
96 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 16
- Chemicals
- 96
- With full pages
- 5
Scaffold SMILES
O=C(CNc1ccccc1)N1CCCCC1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 96 chemicals
N-(2,6-Dimethylphenyl)-N-(2-oxo-2-piperidin-1-ylethyl)methanesulfonamide
CAS 311798-22-8C16H24N2O3S
![N-(2-Chlorophenyl)-N-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]methanesulfonamide chemical structure, C15H21ClN2O3S, CAS 500189-13-9](/s/ANFWWUAELVYAAZ-UHFFFAOYSA-N.svg)
N-(2-Chlorophenyl)-N-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]methanesulfonamide
CAS 500189-13-9C15H21ClN2O3S
N-(2-Methoxy-5-methylphenyl)-N-(2-oxo-2-piperidin-1-ylethyl)methanesulfonamide
CAS 333453-35-3C16H24N2O4S
![2-[N-(Dimethylsulfamoyl)anilino]-1-piperidin-1-ylethanone chemical structure, C15H23N3O3S, CAS 825596-08-5](/s/XNLTXYOAMQNZBN-UHFFFAOYSA-N.svg)
2-[N-(Dimethylsulfamoyl)anilino]-1-piperidin-1-ylethanone
CAS 825596-08-5C15H23N3O3S
N-(3-Acetylphenyl)-N-(2-oxo-2-piperidin-1-ylethyl)methanesulfonamide
CAS 824974-70-1C16H22N2O4S
N-(5-Chloro-2-methoxyphenyl)-N-(2-oxo-2-piperidin-1-ylethyl)methanesulfonamide
CAS 352560-28-2C15H21ClN2O4S
![Ethyl 1-[N-(methylsulfonyl)-N-phenylglycyl]piperidine-4-carboxylate chemical structure, C17H24N2O5S, CAS 528875-92-5](/s/JHRXBIUPZRLJPP-UHFFFAOYSA-N.svg)
Ethyl 1-[N-(methylsulfonyl)-N-phenylglycyl]piperidine-4-carboxylate
CAS 528875-92-5C17H24N2O5S
![1-[2-(4-Iodo-N-methylsulfonylanilino)acetyl]piperidine-4-carboxamide chemical structure, C15H20IN3O4S, CAS 510723-11-2](/s/SCXKSYSDWWETKL-UHFFFAOYSA-N.svg)
1-[2-(4-Iodo-N-methylsulfonylanilino)acetyl]piperidine-4-carboxamide
CAS 510723-11-2C15H20IN3O4S
![1-[2-(4-Chloro-N-methylsulfonylanilino)acetyl]piperidine-4-carboxamide chemical structure, C15H20ClN3O4S, CAS 510723-12-3](/s/FMGKLKNYCYUOQI-UHFFFAOYSA-N.svg)
1-[2-(4-Chloro-N-methylsulfonylanilino)acetyl]piperidine-4-carboxamide
CAS 510723-12-3C15H20ClN3O4S
![Ethyl 1-[N-(2-ethylphenyl)-N-(methylsulfonyl)glycyl]piperidine-4-carboxylate chemical structure, C19H28N2O5S, CAS 462091-77-6](/s/ZEZHKWSUAGBMMJ-UHFFFAOYSA-N.svg)
Ethyl 1-[N-(2-ethylphenyl)-N-(methylsulfonyl)glycyl]piperidine-4-carboxylate
CAS 462091-77-6C19H28N2O5S
![1-[2-[N-Methylsulfonyl-3-(trifluoromethyl)anilino]acetyl]piperidine-4-carboxamide chemical structure, C16H20F3N3O4S, CAS 625822-53-9](/s/PQTHVKCHFIXDFC-UHFFFAOYSA-N.svg)
1-[2-[N-Methylsulfonyl-3-(trifluoromethyl)anilino]acetyl]piperidine-4-carboxamide
CAS 625822-53-9C16H20F3N3O4S
![Ethyl 1-[N-(2-fluorophenyl)-N-(methylsulfonyl)glycyl]piperidine-4-carboxylate chemical structure, C17H23FN2O5S, CAS 592468-34-3](/s/OXYKEDRYBJLIBE-UHFFFAOYSA-N.svg)
Ethyl 1-[N-(2-fluorophenyl)-N-(methylsulfonyl)glycyl]piperidine-4-carboxylate
CAS 592468-34-3C17H23FN2O5S
![Ethyl 1-{N-(methylsulfonyl)-N-[4-(propan-2-yl)phenyl]glycyl}piperidine-4-carboxylate chemical structure, C20H30N2O5S, CAS 446042-77-9](/s/QVQOBPPYZCPREG-UHFFFAOYSA-N.svg)
Ethyl 1-{N-(methylsulfonyl)-N-[4-(propan-2-yl)phenyl]glycyl}piperidine-4-carboxylate
CAS 446042-77-9C20H30N2O5S
N-(3,4-Dimethylphenyl)-N-(2-oxo-2-piperidin-1-ylethyl)methanesulfonamide
CAS 797807-49-9C16H24N2O3S
![N-[2-Chloro-5-(trifluoromethyl)phenyl]-N-(2-oxo-2-piperidin-1-ylethyl)methanesulfonamide chemical structure, C15H18ClF3N2O3S, CAS 442867-58-5](/s/KSYBIKAQAOPXJG-UHFFFAOYSA-N.svg)
N-[2-Chloro-5-(trifluoromethyl)phenyl]-N-(2-oxo-2-piperidin-1-ylethyl)methanesulfonamide
CAS 442867-58-5C15H18ClF3N2O3S
N-(2-Ethoxyphenyl)-N-(2-(4-methylpiperidin-1-yl)-2-oxoethyl)methanesulfonamide
CAS 700859-06-9C17H26N2O4S
![N-(3,4-Dimethoxyphenyl)-N-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]methanesulfonamide chemical structure, C17H26N2O5S, CAS 443295-76-9](/s/CMUIXKNKPBSZKM-UHFFFAOYSA-N.svg)
N-(3,4-Dimethoxyphenyl)-N-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]methanesulfonamide
CAS 443295-76-9C17H26N2O5S
![N-(5-Chloro-2-methoxyphenyl)-N-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]methanesulfonamide chemical structure, C16H23ClN2O4S, CAS 428486-24-2](/s/UJGDWWZFLXPPKV-UHFFFAOYSA-N.svg)
N-(5-Chloro-2-methoxyphenyl)-N-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]methanesulfonamide
CAS 428486-24-2C16H23ClN2O4S
![N-[2-Chloro-5-(trifluoromethyl)phenyl]-N-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]methanesulfonamide chemical structure, C16H20ClF3N2O3S, CAS 432539-75-8](/s/WBNRMWSUFFHSPV-UHFFFAOYSA-N.svg)
N-[2-Chloro-5-(trifluoromethyl)phenyl]-N-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]methanesulfonamide
CAS 432539-75-8C16H20ClF3N2O3S
![1-[2-(2,4,5-Trichloro-N-methylsulfonylanilino)acetyl]piperidine-4-carboxamide chemical structure, C15H18Cl3N3O4S, CAS 5478-89-7](/s/XEODAHVUEAAWMN-UHFFFAOYSA-N.svg)
1-[2-(2,4,5-Trichloro-N-methylsulfonylanilino)acetyl]piperidine-4-carboxamide
CAS 5478-89-7C15H18Cl3N3O4S
![N-(2,4-Dichlorophenyl)-N-[2-oxo-2-(piperidin-1-yl)ethyl]methanesulfonamide chemical structure, C14H18Cl2N2O3S, CAS 343374-06-1](/s/ZOLHJBHBZJTGLV-UHFFFAOYSA-N.svg)
N-(2,4-Dichlorophenyl)-N-[2-oxo-2-(piperidin-1-yl)ethyl]methanesulfonamide
CAS 343374-06-1C14H18Cl2N2O3S
![N-(2,3-Dichlorophenyl)-N-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]methanesulfonamide chemical structure, C15H20Cl2N2O3S, CAS 431996-93-9](/s/KGCXALGEAOKGDR-UHFFFAOYSA-N.svg)
N-(2,3-Dichlorophenyl)-N-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]methanesulfonamide
CAS 431996-93-9C15H20Cl2N2O3S
![N-(2-Methoxyphenyl)-N-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]methanesulfonamide chemical structure, C16H24N2O4S, CAS 4399-72-8](/s/XAEWBYGREAQPOK-UHFFFAOYSA-N.svg)
N-(2-Methoxyphenyl)-N-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]methanesulfonamide
CAS 4399-72-8C16H24N2O4S
![N-[4-Chloro-3-(trifluoromethyl)phenyl]-N-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]methanesulfonamide chemical structure, C16H20ClF3N2O3S, CAS 592469-58-4](/s/HTVGZLJZLRCVAC-UHFFFAOYSA-N.svg)
N-[4-Chloro-3-(trifluoromethyl)phenyl]-N-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]methanesulfonamide
CAS 592469-58-4C16H20ClF3N2O3S
- 2-[N-(Dimethylsulfamoyl)anilino]-1-(4-methylpiperidin-1-yl)ethanone884985-08-4C16H25N3O3S
- N-(3-Acetylphenyl)-N-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]methanesulfonamide832094-63-0C17H24N2O4S
- 1-[N-(3,4-Dimethylphenyl)-N-(methylsulfonyl)alanyl]piperidine-4-carboxamide1008024-09-6C18H27N3O4S
- N-(1-(Piperidinocarbonyl)ethyl)propionanilide96977-55-8C17H24N2O2
- Propionanilide, N-((piperidinocarbonyl)methyl)-97020-72-9C16H22N2O2
- 2-[(2-Methylphenyl)amino]-1-(piperidin-1-yl)ethan-1-one93865-41-9C14H20N2O
- 2-[(4-Methylphenyl)amino]-1-(piperidin-1-yl)ethan-1-one93865-42-0C14H20N2O
- 2-(Phenylamino)-1-(piperidin-1-yl)ethan-1-one92032-55-8C13H18N2O
- Piperidine, 1-(N-methyl-N-phenylglycyl)-98840-89-2C14H20N2O
- N-(2,5-Dichlorophenyl)-N-(1-oxo-1-piperidin-1-ylpropan-2-yl)methanesulfonamide1040555-65-4C15H20Cl2N2O3S
- N-(4-Fluorophenyl)-N-[1-oxo-1-(piperidin-1-yl)propan-2-yl]methanesulfonamide1008233-81-5C15H21FN2O3S
- N-(2-Chlorophenyl)-N-[2-(3-methylpiperidin-1-yl)-2-oxoethyl]methanesulfonamide932195-41-0C15H21ClN2O3S
- N-(4-Methoxyphenyl)-N-[2-(3-methylpiperidin-1-yl)-2-oxoethyl]methanesulfonamide932195-44-3C16H24N2O4S
- N-(2-Ethoxyphenyl)-N-[2-(3-methylpiperidin-1-yl)-2-oxoethyl]methanesulfonamide932210-73-6C17H26N2O4S
- N-(4-Ethylphenyl)-N-[2-(3-methylpiperidin-1-yl)-2-oxoethyl]methanesulfonamide932210-95-2C17H26N2O3S
- Methyl 1-[N-(3-fluorophenyl)-N-(methylsulfonyl)glycyl]piperidine-4-carboxylate932258-21-4C16H21FN2O5S
- Methyl 1-[N-(3,4-dimethylphenyl)-N-(methylsulfonyl)alanyl]piperidine-4-carboxylate1093985-90-0C19H28N2O5S
- Methyl 1-[N-(methylsulfonyl)-N-phenylalanyl]piperidine-4-carboxylate1094101-02-6C17H24N2O5S
- N-[1-(3-Methylpiperidin-1-yl)-1-oxopropan-2-yl]-N-phenylmethanesulfonamide1094163-06-0C16H24N2O3S
- N-[2-(3-Methylpiperidin-1-yl)-2-oxoethyl]-N-phenylmethanesulfonamide928979-15-1C15H22N2O3S
- 2-[N-(Dimethylsulfamoyl)anilino]-1-(3-methylpiperidin-1-yl)ethanone928897-83-0C16H25N3O3S
- N-(4-Fluorophenyl)-N-[2-(3-methylpiperidin-1-yl)-2-oxoethyl]methanesulfonamide928926-56-1C15H21FN2O3S
- 2-Chloro-N-(2-methylphenyl)-N-[2-oxo-2-(piperidin-1-yl)ethyl]propanamide2411221-70-8C17H23ClN2O2
- [(4-Methoxyphenyl)(2-oxo-2-piperidin-1-ylethyl)-amino]acetic acid1142205-63-7C16H22N2O4
Related scaffolds
Same ring framework with different atoms or bond orders
O=C(Nc1ccccc1)Nc1ccccc1421 chemicals
O=C(C=Cc1ccccc1)c1ccccc1389 chemicals
O=C(NCc1ccccc1)c1ccccc1260 chemicals
O=C(Cc1ccccc1)Nc1ccccc1219 chemicals
O=S(=O)(NCc1ccccc1)c1ccccc1164 chemicals
c1ccc(CNCc2ccccc2)cc1142 chemicals
S=C(Nc1ccccc1)Nc1ccccc1109 chemicals
O=C(CCc1ccccc1)c1ccccc187 chemicals
C(=NNc1ccccc1)c1ccccc173 chemicals
O=C(Nc1ccccc1)Oc1ccccc173 chemicals
O=C(OCc1ccccc1)N1CCCCC161 chemicals
O=C(OCc1ccccc1)c1ccccc157 chemicals