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Murcko scaffold

3-Phenyl-5-isoxazolone scaffold

27 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
12
Chemicals
27
With full pages
4
Scaffold SMILES

O=C1CC(c2ccccc2)=NO1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 3-Phenyl-5-isoxazolone page
Murcko scaffold O=C1CC(c2ccccc2)=NO1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 27 of 27 chemicals

3-Phenyl-5-isoxazolone chemical structure, C9H7NO2, CAS 1076-59-1
3-Phenyl-5-isoxazolone
CAS 1076-59-1C9H7NO2
Ethyl 4-hydroxy-5-oxo-3-phenyl-1,2-oxazole-4-carboxylate chemical structure, C12H11NO5, CAS 80490-40-0
Ethyl 4-hydroxy-5-oxo-3-phenyl-1,2-oxazole-4-carboxylate
CAS 80490-40-0C12H11NO5
3-(4-Methoxyphenyl)isoxazol-5(4H)-one chemical structure, C10H9NO3, CAS 31709-47-4
3-(4-Methoxyphenyl)isoxazol-5(4H)-one
CAS 31709-47-4C10H9NO3
5(4H)-isoxazolone, 4-methyl-3-phenyl- chemical structure, C10H9NO2, CAS 23244-37-3
5(4H)-isoxazolone, 4-methyl-3-phenyl-
CAS 23244-37-3C10H9NO2
3-(4-Methylphenyl)-5(4H)-isoxazolone chemical structure, C10H9NO2, CAS 25755-82-2
3-(4-Methylphenyl)-5(4H)-isoxazolone
CAS 25755-82-2C10H9NO2
3-(4-Chlorophenyl)-1,2-oxazol-5(4H)-one chemical structure, C9H6ClNO2, CAS 25755-85-5
3-(4-Chlorophenyl)-1,2-oxazol-5(4H)-one
CAS 25755-85-5C9H6ClNO2
3-(4-Nitrophenyl)isoxazol-5(4H)-one chemical structure, C9H6N2O4, CAS 39214-83-0
3-(4-Nitrophenyl)isoxazol-5(4H)-one
CAS 39214-83-0C9H6N2O4
3-(2,4-Dichlorophenyl)-4H-1,2-oxazol-5-one chemical structure, C9H5Cl2NO2, CAS 352554-51-9
3-(2,4-Dichlorophenyl)-4H-1,2-oxazol-5-one
CAS 352554-51-9C9H5Cl2NO2
4,4-Dibromo-3-phenylisoxazol-5(4H)-one chemical structure, C9H5Br2NO2, CAS 61656-38-0
4,4-Dibromo-3-phenylisoxazol-5(4H)-one
CAS 61656-38-0C9H5Br2NO2
3-(2-Methoxyphenyl)-4,5-dihydro-1,2-oxazol-5-one chemical structure, C10H9NO3, CAS 24031-70-7
3-(2-Methoxyphenyl)-4,5-dihydro-1,2-oxazol-5-one
CAS 24031-70-7C10H9NO3
4-Acetyl-3-phenylisoxazol-5(4H)-one chemical structure, C11H9NO3, CAS 50401-64-4
4-Acetyl-3-phenylisoxazol-5(4H)-one
CAS 50401-64-4C11H9NO3
Ethyl 5-oxo-3-phenyl-4,5-dihydro-1,2-oxazole-4-carboxylate chemical structure, C12H11NO4, CAS 1084-41-9
Ethyl 5-oxo-3-phenyl-4,5-dihydro-1,2-oxazole-4-carboxylate
CAS 1084-41-9C12H11NO4
5(4H)-Isoxazolone, 4-amino-4-ethyl-3-phenyl- chemical structure, C11H12N2O2, CAS 749177-54-6
5(4H)-Isoxazolone, 4-amino-4-ethyl-3-phenyl-
CAS 749177-54-6C11H12N2O2
4-(5-Oxo-4,5-dihydro-1,2-oxazol-3-yl)benzoic acid chemical structure, C10H7NO4, CAS 1429896-69-4
4-(5-Oxo-4,5-dihydro-1,2-oxazol-3-yl)benzoic acid
CAS 1429896-69-4C10H7NO4
3-(2-Chlorophenyl)-1,2-oxazol-5(4H)-one chemical structure, C9H6ClNO2, CAS 27025-73-6
3-(2-Chlorophenyl)-1,2-oxazol-5(4H)-one
CAS 27025-73-6C9H6ClNO2
3-(4-Bromophenyl)-1,2-oxazol-5(4H)-one chemical structure, C9H6BrNO2, CAS 31709-50-9
3-(4-Bromophenyl)-1,2-oxazol-5(4H)-one
CAS 31709-50-9C9H6BrNO2
3-(4-Ethoxyphenyl)-5(4H)-isoxazolone chemical structure, C11H11NO3, CAS 51725-86-1
3-(4-Ethoxyphenyl)-5(4H)-isoxazolone
CAS 51725-86-1C11H11NO3
3-(4-Fluorophenyl)-4,5-dihydro-1,2-oxazol-5-one chemical structure, C9H6FNO2, CAS 31709-51-0
3-(4-Fluorophenyl)-4,5-dihydro-1,2-oxazol-5-one
CAS 31709-51-0C9H6FNO2
3-[3-(Trifluoromethyl)phenyl]-1,2-oxazol-5(4H)-one chemical structure, C10H6F3NO2, CAS 32577-69-8
3-[3-(Trifluoromethyl)phenyl]-1,2-oxazol-5(4H)-one
CAS 32577-69-8C10H6F3NO2
3-(3,4-Dimethoxyphenyl)-1,2-oxazol-5(4H)-one chemical structure, C11H11NO4, CAS 24031-71-8
3-(3,4-Dimethoxyphenyl)-1,2-oxazol-5(4H)-one
CAS 24031-71-8C11H11NO4
3-(2,5-Dimethoxyphenyl)-1,2-oxazol-5(4H)-one chemical structure, C11H11NO4, CAS 38975-91-6
3-(2,5-Dimethoxyphenyl)-1,2-oxazol-5(4H)-one
CAS 38975-91-6C11H11NO4
3-(3-Methoxyphenyl)isoxazol-5(4H)-one chemical structure, C10H9NO3, CAS 248470-38-4
3-(3-Methoxyphenyl)isoxazol-5(4H)-one
CAS 248470-38-4C10H9NO3
3-(4-Iodophenyl)isoxazol-5(4H)-one chemical structure, C9H6INO2, CAS 1366773-07-0
3-(4-Iodophenyl)isoxazol-5(4H)-one
CAS 1366773-07-0C9H6INO2
3-(3-Chlorophenyl)-4,5-dihydro-1,2-oxazol-5-one chemical structure, C9H6ClNO2, CAS 51725-85-0
3-(3-Chlorophenyl)-4,5-dihydro-1,2-oxazol-5-one
CAS 51725-85-0C9H6ClNO2