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Murcko scaffold

N-Thiazol-2-yl-isonicotinamide scaffold

35 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
14
Chemicals
35
With full pages
4
Scaffold SMILES

O=C(N=c1[nH]ccs1)c1ccncc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the N-Thiazol-2-yl-isonicotinamide page
Murcko scaffold O=C(N=c1[nH]ccs1)c1ccncc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 35 of 35 chemicals

N-[3-[2-(Dimethylamino)-2-oxoethyl]-5-nitro-1,3-thiazol-2-ylidene]pyridine-4-carboxamide chemical structure, C13H13N5O4S, CAS 30515-58-3
N-[3-[2-(Dimethylamino)-2-oxoethyl]-5-nitro-1,3-thiazol-2-ylidene]pyridine-4-carboxamide
CAS 30515-58-3C13H13N5O4S
Ethyl 2-(isonicotinamido)-4-methylthiazole-5-carboxylate chemical structure, C13H13N3O3S, CAS 302806-49-1
Ethyl 2-(isonicotinamido)-4-methylthiazole-5-carboxylate
CAS 302806-49-1C13H13N3O3S
N-Thiazol-2-yl-isonicotinamide chemical structure, C9H7N3OS, CAS 14397-13-8
N-Thiazol-2-yl-isonicotinamide
CAS 14397-13-8C9H7N3OS
2-tert-Butyl-N-(1,3-thiazol-2-yl)pyridine-4-carboxamide chemical structure, C13H15N3OS, CAS 622341-65-5
2-tert-Butyl-N-(1,3-thiazol-2-yl)pyridine-4-carboxamide
CAS 622341-65-5C13H15N3OS
N-(4-tert-Butyl-1,3-thiazol-2-yl)pyridine-4-carboxamide chemical structure, C13H15N3OS, CAS 303787-13-5
N-(4-tert-Butyl-1,3-thiazol-2-yl)pyridine-4-carboxamide
CAS 303787-13-5C13H15N3OS
N-(4-Methyl-1,3-thiazol-2-yl)pyridine-4-carboxamide chemical structure, C10H9N3OS, CAS 14490-95-0
N-(4-Methyl-1,3-thiazol-2-yl)pyridine-4-carboxamide
CAS 14490-95-0C10H9N3OS
N-(4-tert-Butyl-1,3-thiazol-2-yl)-2-chloropyridine-4-carboxamide chemical structure, C13H14ClN3OS, CAS 680217-97-4
N-(4-tert-Butyl-1,3-thiazol-2-yl)-2-chloropyridine-4-carboxamide
CAS 680217-97-4C13H14ClN3OS
[2-(Isonicotinoylamino)-1,3-thiazol-4-yl]acetic acid chemical structure, C11H9N3O3S, CAS 926255-86-9
[2-(Isonicotinoylamino)-1,3-thiazol-4-yl]acetic acid
CAS 926255-86-9C11H9N3O3S
2-(Isonicotinoylamino)-1,3-thiazole-4-carboxylic acid chemical structure, C10H7N3O3S, CAS 1082152-97-3
2-(Isonicotinoylamino)-1,3-thiazole-4-carboxylic acid
CAS 1082152-97-3C10H7N3O3S
2-Chloro-N-(dimethyl-1,3-thiazol-2-yl)pyridine-4-carboxamide chemical structure, C11H10ClN3OS, CAS 1118822-89-1
2-Chloro-N-(dimethyl-1,3-thiazol-2-yl)pyridine-4-carboxamide
CAS 1118822-89-1C11H10ClN3OS
2-Chloro-N-methyl-N-(4-methyl-1,3-thiazol-2-yl)pyridine-4-carboxamide chemical structure, C11H10ClN3OS, CAS 1209995-57-2
2-Chloro-N-methyl-N-(4-methyl-1,3-thiazol-2-yl)pyridine-4-carboxamide
CAS 1209995-57-2C11H10ClN3OS
2-Chloro-N-(4-ethyl-5-methyl-1,3-thiazol-2-yl)pyridine-4-carboxamide chemical structure, C12H12ClN3OS, CAS 1223459-94-6
2-Chloro-N-(4-ethyl-5-methyl-1,3-thiazol-2-yl)pyridine-4-carboxamide
CAS 1223459-94-6C12H12ClN3OS
Ethyl 2-[(pyridin-4-ylcarbonyl)amino]-1,3-thiazole-4-carboxylate chemical structure, C12H11N3O3S, CAS 1282126-01-5
Ethyl 2-[(pyridin-4-ylcarbonyl)amino]-1,3-thiazole-4-carboxylate
CAS 1282126-01-5C12H11N3O3S
N-(4-Acetyl-1,3-thiazol-2-yl)-2-chloropyridine-4-carboxamide chemical structure, C11H8ClN3O2S, CAS 1356762-29-2
N-(4-Acetyl-1,3-thiazol-2-yl)-2-chloropyridine-4-carboxamide
CAS 1356762-29-2C11H8ClN3O2S
Methyl 4-(2-methoxy-2-oxoethyl)-2-[(pyridin-4-ylcarbonyl)amino]-1,3-thiazole-5-carboxylate chemical structure, C14H13N3O5S, CAS 1282133-90-7
Methyl 4-(2-methoxy-2-oxoethyl)-2-[(pyridin-4-ylcarbonyl)amino]-1,3-thiazole-5-carboxylate
CAS 1282133-90-7C14H13N3O5S
3-Chloro-N-(5-methylthiazol-2-yl)isonicotinamide chemical structure, C10H8ClN3OS, CAS 1501666-37-0
3-Chloro-N-(5-methylthiazol-2-yl)isonicotinamide
CAS 1501666-37-0C10H8ClN3OS
N-[4-Chloro-5-(methylamino)-1,3-thiazol-2-yl]pyridine-4-carboxamide chemical structure, C10H9ClN4OS, CAS 828920-75-8
N-[4-Chloro-5-(methylamino)-1,3-thiazol-2-yl]pyridine-4-carboxamide
CAS 828920-75-8C10H9ClN4OS
N-(5-Amino-4-chloro-1,3-thiazol-2-yl)pyridine-4-carboxamide chemical structure, C9H7ClN4OS, CAS 828920-66-7
N-(5-Amino-4-chloro-1,3-thiazol-2-yl)pyridine-4-carboxamide
CAS 828920-66-7C9H7ClN4OS
N-{5-[(2-Hydroxyethyl)amino]-1,3-thiazol-2-yl}pyridine-4-carboxamide chemical structure, C11H12N4O2S, CAS 828920-57-6
N-{5-[(2-Hydroxyethyl)amino]-1,3-thiazol-2-yl}pyridine-4-carboxamide
CAS 828920-57-6C11H12N4O2S
N-[5-(Methylamino)-1,3-thiazol-2-yl]pyridine-4-carboxamide chemical structure, C10H10N4OS, CAS 828920-48-5
N-[5-(Methylamino)-1,3-thiazol-2-yl]pyridine-4-carboxamide
CAS 828920-48-5C10H10N4OS
N-(5-Amino-1,3-thiazol-2-yl)pyridine-4-carboxamide chemical structure, C9H8N4OS, CAS 828920-40-7
N-(5-Amino-1,3-thiazol-2-yl)pyridine-4-carboxamide
CAS 828920-40-7C9H8N4OS
N-(5-Ethyl-1,3-thiazol-2-yl)-2-fluoropyridine-4-carboxamide chemical structure, C11H10FN3OS, CAS 1436052-92-4
N-(5-Ethyl-1,3-thiazol-2-yl)-2-fluoropyridine-4-carboxamide
CAS 1436052-92-4C11H10FN3OS
N-(5-Chloro-1,3-thiazol-2-yl)-2-fluoropyridine-4-carboxamide chemical structure, C9H5ClFN3OS, CAS 1384667-09-7
N-(5-Chloro-1,3-thiazol-2-yl)-2-fluoropyridine-4-carboxamide
CAS 1384667-09-7C9H5ClFN3OS
N-[4-(Carbamoylmethyl)-1,3-thiazol-2-yl]-2-fluoropyridine-4-carboxamide chemical structure, C11H9FN4O2S, CAS 1376327-96-6
N-[4-(Carbamoylmethyl)-1,3-thiazol-2-yl]-2-fluoropyridine-4-carboxamide
CAS 1376327-96-6C11H9FN4O2S