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Murcko scaffold

Ring system with 3 rings and 20 atoms

32 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 20
Chemicals: 32
With full pages: 4

Scaffold SMILES

O=C(C=Cc1c[nH]c2ccccc12)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(C=Cc1c[nH]c2ccccc12)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 32 of 32 chemicals

(2E)-N-(3-Chlorophenyl)-2-cyano-3-(1H-indol-3-yl)prop-2-enamide chemical structure, C18H12ClN3O, CAS 357617-74-4

(2E)-N-(3-Chlorophenyl)-2-cyano-3-(1H-indol-3-yl)prop-2-enamide

CAS 357617-74-4C₁₈H₁₂ClN₃O

(E)-N-(2-Chlorophenyl)-2-cyano-3-(1H-indol-3-yl)acrylamide chemical structure, C18H12ClN3O, CAS 327076-65-3

(E)-N-(2-Chlorophenyl)-2-cyano-3-(1H-indol-3-yl)acrylamide

CAS 327076-65-3C₁₈H₁₂ClN₃O

(E)-2-Cyano-N-(2-methoxyphenyl)-3-(1-methyl-1H-indol-3-yl)acrylamide chemical structure, C20H17N3O2, CAS 327076-77-7

(E)-2-Cyano-N-(2-methoxyphenyl)-3-(1-methyl-1H-indol-3-yl)acrylamide

CAS 327076-77-7C₂₀H₁₇N₃O₂

(Z)-2-Cyano-3-(1-ethylindol-3-yl)-N-(4-methoxyphenyl)prop-2-enamide chemical structure, C21H19N3O2, CAS 357969-00-7

(Z)-2-Cyano-3-(1-ethylindol-3-yl)-N-(4-methoxyphenyl)prop-2-enamide

CAS 357969-00-7C₂₁H₁₉N₃O₂

(2E)-2-Cyano-3-(1H-indol-3-yl)-N-(4-methoxyphenyl)prop-2-enamide chemical structure, C19H15N3O2, CAS 5871-09-0

(2E)-2-Cyano-3-(1H-indol-3-yl)-N-(4-methoxyphenyl)prop-2-enamide

CAS 5871-09-0C₁₉H₁₅N₃O₂

(E)-N-(3-Chloro-2-methylphenyl)-2-cyano-3-(1H-indol-3-yl)prop-2-enamide chemical structure, C19H14ClN3O, CAS 5915-95-7

(E)-N-(3-Chloro-2-methylphenyl)-2-cyano-3-(1H-indol-3-yl)prop-2-enamide

CAS 5915-95-7C₁₉H₁₄ClN₃O

(E)-2-Cyano-3-(1H-indol-3-yl)-N-(3-nitrophenyl)acrylamide chemical structure, C18H12N4O3, CAS 327076-67-5

(E)-2-Cyano-3-(1H-indol-3-yl)-N-(3-nitrophenyl)acrylamide

CAS 327076-67-5C₁₈H₁₂N₄O₃

(Z)-N-(4-Chlorophenyl)-2-cyano-3-(1-prop-2-ynylindol-3-yl)prop-2-enamide chemical structure, C21H14ClN3O, CAS 340312-01-8

(Z)-N-(4-Chlorophenyl)-2-cyano-3-(1-prop-2-ynylindol-3-yl)prop-2-enamide

CAS 340312-01-8C₂₁H₁₄ClN₃O

(Z)-2-Cyano-N-(4-methoxyphenyl)-3-(2-methyl-1-prop-2-enylindol-3-yl)prop-2-enamide chemical structure, C23H21N3O2, CAS 5910-61-2

(Z)-2-Cyano-N-(4-methoxyphenyl)-3-(2-methyl-1-prop-2-enylindol-3-yl)prop-2-enamide

CAS 5910-61-2C₂₃H₂₁N₃O₂

(E)-2-Cyano-N-(2-methoxyphenyl)-3-(1-prop-2-enylindol-3-yl)prop-2-enamide chemical structure, C22H19N3O2, CAS 5971-86-8

(E)-2-Cyano-N-(2-methoxyphenyl)-3-(1-prop-2-enylindol-3-yl)prop-2-enamide

CAS 5971-86-8C₂₂H₁₉N₃O₂

(E)-2-Cyano-3-(1H-indol-3-yl)-N-(3-(trifluoromethyl)phenyl)acrylamide chemical structure, C19H12F3N3O, CAS 327076-69-7

(E)-2-Cyano-3-(1H-indol-3-yl)-N-(3-(trifluoromethyl)phenyl)acrylamide

CAS 327076-69-7C₁₉H₁₂F₃N₃O

(E)-N-[2-Chloro-5-(trifluoromethyl)phenyl]-2-cyano-3-(1H-indol-3-yl)prop-2-enamide chemical structure, C19H11ClF3N3O, CAS 465510-58-1

(E)-N-[2-Chloro-5-(trifluoromethyl)phenyl]-2-cyano-3-(1H-indol-3-yl)prop-2-enamide

CAS 465510-58-1C₁₉H₁₁ClF₃N₃O

N-(2-Bromophenyl)-2-cyano-3-(1H-indol-3-yl)prop-2-enamide chemical structure, C18H12BrN3O, CAS 358764-63-3

N-(2-Bromophenyl)-2-cyano-3-(1H-indol-3-yl)prop-2-enamide

CAS 358764-63-3C₁₈H₁₂BrN₃O

3-(5-Bromo-1H-indol-3-yl)-2-cyano-N-(3,4-dimethoxyphenyl)prop-2-enamide chemical structure, C20H16BrN3O3, CAS 717826-31-8

3-(5-Bromo-1H-indol-3-yl)-2-cyano-N-(3,4-dimethoxyphenyl)prop-2-enamide

CAS 717826-31-8C₂₀H₁₆BrN₃O₃

(E)-2-Cyano-3-(2-methyl-1H-indol-3-yl)-N-[3-(trifluoromethyl)phenyl]prop-2-enamide chemical structure, C20H14F3N3O, CAS 717142-33-1

(E)-2-Cyano-3-(2-methyl-1H-indol-3-yl)-N-[3-(trifluoromethyl)phenyl]prop-2-enamide

CAS 717142-33-1C₂₀H₁₄F₃N₃O

Ethyl 4-[[(E)-2-cyano-3-(1H-indol-3-yl)prop-2-enoyl]amino]benzoate chemical structure, C21H17N3O3, CAS 359424-60-5

Ethyl 4-[[(E)-2-cyano-3-(1H-indol-3-yl)prop-2-enoyl]amino]benzoate

CAS 359424-60-5C₂₁H₁₇N₃O₃

N-(4-Chloro-2-methoxy-5-methylphenyl)-2-cyano-3-(1H-indol-3-yl)prop-2-enamide chemical structure, C20H16ClN3O2, CAS 748779-73-9

N-(4-Chloro-2-methoxy-5-methylphenyl)-2-cyano-3-(1H-indol-3-yl)prop-2-enamide

CAS 748779-73-9C₂₀H₁₆ClN₃O₂

2-Cyano-N-(4-hydroxyphenyl)-3-(1-methyl-1H-indol-3-yl)-2-propenamide chemical structure, C19H15N3O2, CAS 1025529-31-0

2-Cyano-N-(4-hydroxyphenyl)-3-(1-methyl-1H-indol-3-yl)-2-propenamide

CAS 1025529-31-0C₁₉H₁₅N₃O₂

(E)-2-Cyano-3-(1H-indol-3-yl)-N-(4-nitrophenyl)acrylamide chemical structure, C18H12N4O3, CAS 332919-74-1

(E)-2-Cyano-3-(1H-indol-3-yl)-N-(4-nitrophenyl)acrylamide

CAS 332919-74-1C₁₈H₁₂N₄O₃

(2E)-2-Cyano-3-(1H-indol-3-yl)-N-(2,4,6-trimethylphenyl)prop-2-enamide chemical structure, C21H19N3O, CAS 501109-51-9

(2E)-2-Cyano-3-(1H-indol-3-yl)-N-(2,4,6-trimethylphenyl)prop-2-enamide

CAS 501109-51-9C₂₁H₁₉N₃O

(E)-2-Cyano-3-(1H-indol-3-yl)-N-(2-nitrophenyl)acrylamide chemical structure, C18H12N4O3, CAS 327076-66-4

(E)-2-Cyano-3-(1H-indol-3-yl)-N-(2-nitrophenyl)acrylamide

CAS 327076-66-4C₁₈H₁₂N₄O₃

2-Propenamide, 3-(1H-indol-3-yl)-N-(4-methoxyphenyl)-, (E)- chemical structure, C18H16N2O2, CAS 70882-64-3

2-Propenamide, 3-(1H-indol-3-yl)-N-(4-methoxyphenyl)-, (E)-

CAS 70882-64-3C₁₈H₁₆N₂O₂

2-Propenamide, 3-(1H-indol-3-yl)-N-(3-nitrophenyl)-, (E)- chemical structure, C17H13N3O3, CAS 70882-65-4

2-Propenamide, 3-(1H-indol-3-yl)-N-(3-nitrophenyl)-, (E)-

CAS 70882-65-4C₁₇H₁₃N₃O₃

Gavestinel chemical structure, C18H12Cl2N2O3, CAS 153436-22-7

CAS 153436-22-7C₁₈H₁₂Cl₂N₂O₃