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Murcko scaffold

5-Benzyl-2-sulfanylidene-2,3-dihydropyrimidin-4(1H)-one scaffold

41 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
15
Chemicals
41
With full pages
11
Scaffold SMILES

O=c1[nH]c(=S)[nH]cc1Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 5-Benzyl-2-sulfanylidene-2,3-dihydropyrimidin-4(1H)-one page
Murcko scaffold O=c1[nH]c(=S)[nH]cc1Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 41 of 41 chemicals

5-[(5-Acetyl-2-ethoxyphenyl)methyl]-6-hydroxy-2-sulfanylidene-1H-pyrimidin-4-one chemical structure, C15H16N2O4S, CAS 78927-62-5
5-[(5-Acetyl-2-ethoxyphenyl)methyl]-6-hydroxy-2-sulfanylidene-1H-pyrimidin-4-one
CAS 78927-62-5C15H16N2O4S
5-Benzyl-6-methylthiouracil chemical structure, C12H12N2OS, CAS 36361-79-2
5-Benzyl-6-methylthiouracil
CAS 36361-79-2C12H12N2OS
5-(4-Fluorobenzyl)-2-mercapto-6-methylpyrimidin-4-ol chemical structure, C12H11FN2OS, CAS 862104-74-3
5-(4-Fluorobenzyl)-2-mercapto-6-methylpyrimidin-4-ol
CAS 862104-74-3C12H11FN2OS
5-[(5-Acetyl-2-propan-2-yloxyphenyl)methyl]-6-hydroxy-2-sulfanylidene-1H-pyrimidin-4-one chemical structure, C16H18N2O4S, CAS 78927-64-7
5-[(5-Acetyl-2-propan-2-yloxyphenyl)methyl]-6-hydroxy-2-sulfanylidene-1H-pyrimidin-4-one
CAS 78927-64-7C16H18N2O4S
5-(4-Isobutoxy-benzyl)-2-mercapto-pyrimidine-4,6-diol chemical structure, C15H18N2O3S, CAS 57737-29-8
5-(4-Isobutoxy-benzyl)-2-mercapto-pyrimidine-4,6-diol
CAS 57737-29-8C15H18N2O3S
5-[(5-Acetyl-2-methoxyphenyl)methyl]-6-hydroxy-2-sulfanylidene-1H-pyrimidin-4-one chemical structure, C14H14N2O4S, CAS 78927-61-4
5-[(5-Acetyl-2-methoxyphenyl)methyl]-6-hydroxy-2-sulfanylidene-1H-pyrimidin-4-one
CAS 78927-61-4C14H14N2O4S
6-(Ethoxymethyl)-5-[[4-(2-methylpropoxy)phenyl]methyl]-2-sulfanylidene-1H-pyrimidin-4-one chemical structure, C18H24N2O3S, CAS 55342-48-8
6-(Ethoxymethyl)-5-[[4-(2-methylpropoxy)phenyl]methyl]-2-sulfanylidene-1H-pyrimidin-4-one
CAS 55342-48-8C18H24N2O3S
5-[(4-Butoxyphenyl)methyl]-6-(ethoxymethyl)-2-sulfanylidene-1H-pyrimidin-4-one chemical structure, C18H24N2O3S, CAS 55342-47-7
5-[(4-Butoxyphenyl)methyl]-6-(ethoxymethyl)-2-sulfanylidene-1H-pyrimidin-4-one
CAS 55342-47-7C18H24N2O3S
5-[(5-Acetyl-2-propoxyphenyl)methyl]-6-hydroxy-2-sulfanylidene-1H-pyrimidin-4-one chemical structure, C16H18N2O4S, CAS 78927-63-6
5-[(5-Acetyl-2-propoxyphenyl)methyl]-6-hydroxy-2-sulfanylidene-1H-pyrimidin-4-one
CAS 78927-63-6C16H18N2O4S
6-(Ethoxymethyl)-5-[(4-propan-2-yloxyphenyl)methyl]-2-sulfanylidene-1H-pyrimidin-4-one chemical structure, C17H22N2O3S, CAS 55342-46-6
6-(Ethoxymethyl)-5-[(4-propan-2-yloxyphenyl)methyl]-2-sulfanylidene-1H-pyrimidin-4-one
CAS 55342-46-6C17H22N2O3S
6-Hydroxy-5-[(3-methyl-4-propoxyphenyl)methyl]-2-sulfanylidene-1H-pyrimidin-4-one chemical structure, C15H18N2O3S, CAS 332414-27-4
6-Hydroxy-5-[(3-methyl-4-propoxyphenyl)methyl]-2-sulfanylidene-1H-pyrimidin-4-one
CAS 332414-27-4C15H18N2O3S
6-(Ethoxymethyl)-5-[(4-methoxyphenyl)methyl]-2-sulfanylidene-1H-pyrimidin-4-one chemical structure, C15H18N2O3S, CAS 55342-43-3
6-(Ethoxymethyl)-5-[(4-methoxyphenyl)methyl]-2-sulfanylidene-1H-pyrimidin-4-one
CAS 55342-43-3C15H18N2O3S
5-[(2-Chloro-6-fluorophenyl)methyl]-6-methyl-2-sulfanylidene-1H-pyrimidin-4-one chemical structure, C12H10ClFN2OS, CAS 4774-77-0
5-[(2-Chloro-6-fluorophenyl)methyl]-6-methyl-2-sulfanylidene-1H-pyrimidin-4-one
CAS 4774-77-0C12H10ClFN2OS
5-((4-Chlorophenyl)methyl)-2,3-dihydro-6-methyl-2-thioxo-4(1H)-pyrimidinone chemical structure, C12H11ClN2OS, CAS 36327-93-2
5-((4-Chlorophenyl)methyl)-2,3-dihydro-6-methyl-2-thioxo-4(1H)-pyrimidinone
CAS 36327-93-2C12H11ClN2OS
5-(2-Chlorobenzyl)-2-mercapto-6-methylpyrimidin-4-ol chemical structure, C12H11ClN2OS, CAS 500156-98-9
5-(2-Chlorobenzyl)-2-mercapto-6-methylpyrimidin-4-ol
CAS 500156-98-9C12H11ClN2OS
5-(4-Isopropoxy-3-methyl-benzyl)-2-mercapto-pyrimidine-4,6-diol chemical structure, C15H18N2O3S, CAS 331665-73-7
5-(4-Isopropoxy-3-methyl-benzyl)-2-mercapto-pyrimidine-4,6-diol
CAS 331665-73-7C15H18N2O3S
2-Mercapto-5-(4-chlorobenzyl)orotic aldehyde chemical structure, C12H9ClN2O2S, CAS 31349-81-2
2-Mercapto-5-(4-chlorobenzyl)orotic aldehyde
CAS 31349-81-2C12H9ClN2O2S
5-[(2,6-Dichlorophenyl)methyl]-6-(dimethoxymethyl)-2-sulfanylidene-2,3-dihydropyrimidin-4(1H)-one chemical structure, C14H14Cl2N2O3S, CAS 21326-10-3
5-[(2,6-Dichlorophenyl)methyl]-6-(dimethoxymethyl)-2-sulfanylidene-2,3-dihydropyrimidin-4(1H)-one
CAS 21326-10-3C14H14Cl2N2O3S
5-[(2,5-Dimethylphenyl)methyl]-6-oxo-2-sulfanylidene-1,2,3,6-tetrahydropyrimidine-4-carbaldehyde chemical structure, C14H14N2O2S, CAS 31349-87-8
5-[(2,5-Dimethylphenyl)methyl]-6-oxo-2-sulfanylidene-1,2,3,6-tetrahydropyrimidine-4-carbaldehyde
CAS 31349-87-8C14H14N2O2S
6-(Dimethoxymethyl)-5-[(2,5-dimethylphenyl)methyl]-2-sulfanylidene-2,3-dihydropyrimidin-4(1H)-one chemical structure, C16H20N2O3S, CAS 31349-17-4
6-(Dimethoxymethyl)-5-[(2,5-dimethylphenyl)methyl]-2-sulfanylidene-2,3-dihydropyrimidin-4(1H)-one
CAS 31349-17-4C16H20N2O3S
5-[(4-Chlorophenyl)methyl]-6-[(E)-{[2-(dimethylamino)ethyl]imino}methyl]-2-sulfanylidene-2,3-dihydropyrimidin-4(1H)-one chemical structure, C16H19ClN4OS, CAS 31349-11-8
5-[(4-Chlorophenyl)methyl]-6-[(E)-{[2-(dimethylamino)ethyl]imino}methyl]-2-sulfanylidene-2,3-dihydropyrimidin-4(1H)-one
CAS 31349-11-8C16H19ClN4OS
5-[(3-Chlorophenyl)methyl]-6-(dimethoxymethyl)-2-sulfanylidene-1H-pyrimidin-4-one chemical structure, C14H15ClN2O3S, CAS 21326-07-8
5-[(3-Chlorophenyl)methyl]-6-(dimethoxymethyl)-2-sulfanylidene-1H-pyrimidin-4-one
CAS 21326-07-8C14H15ClN2O3S
5-[(2,6-Dichlorophenyl)methyl]-4-oxo-2-sulfanylidene-1H-pyrimidine-6-carbaldehyde chemical structure, C12H8Cl2N2O2S, CAS 21326-33-0
5-[(2,6-Dichlorophenyl)methyl]-4-oxo-2-sulfanylidene-1H-pyrimidine-6-carbaldehyde
CAS 21326-33-0C12H8Cl2N2O2S
5-[(3-Ethoxyphenyl)methyl]-2-sulfanylidene-2,3-dihydropyrimidin-4(1H)-one chemical structure, C13H14N2O2S, CAS 28495-91-2
5-[(3-Ethoxyphenyl)methyl]-2-sulfanylidene-2,3-dihydropyrimidin-4(1H)-one
CAS 28495-91-2C13H14N2O2S