Murcko scaffold
5,6-Dihydro-4H-cyclopenta[b]thiophene scaffold
486 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 8
- Chemicals
- 486
- With full pages
- 40
Scaffold SMILES
c1cc2c(s1)CCC2
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 486 chemicals
2-Amino-4H,5H,6H-cyclopenta(b)thiophene-3-carbonitrile
CAS 70291-62-2C8H8N2S
![Ethyl 2-amino-4H,5H,6H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C10H13NO2S, CAS 4815-29-6](/s/BOJXCJDYZJSPMZ-UHFFFAOYSA-N.svg)
Ethyl 2-amino-4H,5H,6H-cyclopenta[b]thiophene-3-carboxylate
CAS 4815-29-6C10H13NO2S
![Diethyl 2-amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3,4-dicarboxylate chemical structure, C13H17NO4S, CAS 1029689-54-0](/s/KFVIJNDDNWYXSZ-UHFFFAOYSA-N.svg)
Diethyl 2-amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3,4-dicarboxylate
CAS 1029689-54-0C13H17NO4S
![Ethyl 2-amino-3-cyano-4-methyl-5,6-dihydrocyclopenta[b]thiophene-4-carboxylate chemical structure, C12H14N2O2S, CAS 175599-81-2](/s/ITJDYMOUDAANMI-UHFFFAOYSA-N.svg)
Ethyl 2-amino-3-cyano-4-methyl-5,6-dihydrocyclopenta[b]thiophene-4-carboxylate
CAS 175599-81-2C12H14N2O2S
![2-Amino-4H,5H,6H-cyclopenta[b]thiophene-3-carboxamide chemical structure, C8H10N2OS, CAS 77651-38-8](/s/CIYGFKXNRTYHLB-UHFFFAOYSA-N.svg)
2-Amino-4H,5H,6H-cyclopenta[b]thiophene-3-carboxamide
CAS 77651-38-8C8H10N2OS
![Methyl 2-[(trifluoroacetyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C11H10F3NO3S, CAS 304668-20-0](/s/XPJCIGIWSKXICA-UHFFFAOYSA-N.svg)
Methyl 2-[(trifluoroacetyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate
CAS 304668-20-0C11H10F3NO3S
![N-(3-Cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-2,2,2-trifluoroacetamide chemical structure, C10H7F3N2OS, CAS 314282-42-3](/s/QWZHTJXNBFZNCN-UHFFFAOYSA-N.svg)
N-(3-Cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-2,2,2-trifluoroacetamide
CAS 314282-42-3C10H7F3N2OS
![Ethyl 2-[(trifluoroacetyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C12H12F3NO3S, CAS 314282-52-5](/s/HTFAWYXPMMBPLN-UHFFFAOYSA-N.svg)
Ethyl 2-[(trifluoroacetyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate
CAS 314282-52-5C12H12F3NO3S
![N-(3-Cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)acetamide chemical structure, C10H10N2OS, CAS 144038-79-9](/s/SVVQBULYYMXCDX-UHFFFAOYSA-N.svg)
N-(3-Cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)acetamide
CAS 144038-79-9C10H10N2OS
![(E)-4-{[3-(Methoxycarbonyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl]amino}-4-oxo-2-butenoic acid chemical structure, C13H13NO5S, CAS 314282-35-4](/s/YBYMBGPWJJKZNZ-UHFFFAOYSA-N.svg)
(E)-4-{[3-(Methoxycarbonyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl]amino}-4-oxo-2-butenoic acid
CAS 314282-35-4C13H13NO5S
![Ethyl 2-formamido-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C11H13NO3S, CAS 312939-56-3](/s/BGWVDRPZXMCPLG-UHFFFAOYSA-N.svg)
Ethyl 2-formamido-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate
CAS 312939-56-3C11H13NO3S
![Ethyl 2-(3-propionylthioureido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C14H18N2O3S2, CAS 312946-27-3](/s/WFZITJYBKPIKIG-UHFFFAOYSA-N.svg)
Ethyl 2-(3-propionylthioureido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate
CAS 312946-27-3C14H18N2O3S2
4H,5H,6H-Cyclopenta(b)thiophene-2-carboxylic acid
CAS 40133-06-0C8H8O2S
![Propyl 2-amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C11H15NO2S, CAS 350992-19-7](/s/CYWIEOWOBJPEMV-UHFFFAOYSA-N.svg)
Propyl 2-amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate
CAS 350992-19-7C11H15NO2S
![2-(2-Ethylbutanamido)-4H,5H,6H-cyclopenta[b]thiophene-3-carboxylic acid chemical structure, C14H19NO3S, CAS 757220-67-0](/s/URHNXJISIWKBJE-UHFFFAOYSA-N.svg)
2-(2-Ethylbutanamido)-4H,5H,6H-cyclopenta[b]thiophene-3-carboxylic acid
CAS 757220-67-0C14H19NO3S
![5,6-Dihydro-4H-cyclopenta[b]thiophene-2-carbohydrazide chemical structure, C8H10N2OS, CAS 750599-01-0](/s/PNALDFYPMMIOAR-UHFFFAOYSA-N.svg)
5,6-Dihydro-4H-cyclopenta[b]thiophene-2-carbohydrazide
CAS 750599-01-0C8H10N2OS
![Methyl 3-amino-5,6-dihydro-4H-cyclopenta[b]thiophene-2-carboxylate chemical structure, C9H11NO2S, CAS 160133-73-3](/s/UGXVBUYVZYIKNW-UHFFFAOYSA-N.svg)
Methyl 3-amino-5,6-dihydro-4H-cyclopenta[b]thiophene-2-carboxylate
CAS 160133-73-3C9H11NO2S
![Ethyl 2-acetamido-4H,5H,6H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C12H15NO3S, CAS 65416-88-8](/s/RXOGSWSWWJSKGQ-UHFFFAOYSA-N.svg)
Ethyl 2-acetamido-4H,5H,6H-cyclopenta[b]thiophene-3-carboxylate
CAS 65416-88-8C12H15NO3S
![Ethyl 2-(2-methylpropanamido)-4H,5H,6H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C14H19NO3S, CAS 300828-67-5](/s/VHHSSELDHOEOGE-UHFFFAOYSA-N.svg)
Ethyl 2-(2-methylpropanamido)-4H,5H,6H-cyclopenta[b]thiophene-3-carboxylate
CAS 300828-67-5C14H19NO3S
![Ethyl 2-(2,2-dimethylpropanamido)-4H,5H,6H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C15H21NO3S, CAS 300828-69-7](/s/WHJXCLQXXPDOFJ-UHFFFAOYSA-N.svg)
Ethyl 2-(2,2-dimethylpropanamido)-4H,5H,6H-cyclopenta[b]thiophene-3-carboxylate
CAS 300828-69-7C15H21NO3S
![2-(2-Chloro-acetylamino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylic acid ethyl ester chemical structure, C12H14ClNO3S, CAS 203385-15-3](/s/ZUCFVJPQTDOHSC-UHFFFAOYSA-N.svg)
2-(2-Chloro-acetylamino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylic acid ethyl ester
CAS 203385-15-3C12H14ClNO3S
![Dimethyl 2-(propanoylamino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3,4-dicarboxylate chemical structure, C14H17NO5S, CAS 307506-25-8](/s/MDLPUSVEFZJCSV-UHFFFAOYSA-N.svg)
Dimethyl 2-(propanoylamino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3,4-dicarboxylate
CAS 307506-25-8C14H17NO5S
![Dimethyl 2-[(dichloroacetyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3,4-dicarboxylate chemical structure, C13H13Cl2NO5S, CAS 302577-36-2](/s/ZJMJTLFMPPKEKC-UHFFFAOYSA-N.svg)
Dimethyl 2-[(dichloroacetyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3,4-dicarboxylate
CAS 302577-36-2C13H13Cl2NO5S
![Dimethyl 2-[(trifluoroacetyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3,4-dicarboxylate chemical structure, C13H12F3NO5S, CAS 302577-37-3](/s/NUMQAMDELRTYRM-UHFFFAOYSA-N.svg)
Dimethyl 2-[(trifluoroacetyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3,4-dicarboxylate
CAS 302577-37-3C13H12F3NO5S
- Methyl 2-(isobutyrylamino)-5,6-dihydro-4H-cyclopenta(B)thiophene-3-carboxylate302803-00-5C13H17NO3S
- Dimethyl 2-amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3,4-dicarboxylate302949-27-5C11H13NO4S
- Methyl 2-[(4-chlorobutanoyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate302952-44-9C13H16ClNO3S
- Methyl 2-(butoxycarbonylamino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate329226-48-4C14H19NO4S
- Dimethyl 2-[(butoxycarbonyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3,4-dicarboxylate370852-42-9C16H21NO6S
- Ethyl 2-amino-3-cyano-5,6-dihydro-4H-cyclopenta[b]thiophene-4-carboxylate175599-80-1C11H12N2O2S
- Methyl 2-amino-4H,5H,6H-cyclopenta(b)thiophene-3-carboxylate184174-80-9C9H11NO2S
- Ethyl 2-(3-allylthioureido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate124009-46-7C14H18N2O2S2
- Ethyl 2-(2-methylprop-2-enylcarbamothioylamino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate327168-18-3C15H20N2O2S2
- Ethyl 2-(acetylcarbamothioylamino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate325823-13-0C13H16N2O3S2
- 4H-Cyclopenta(b)thiophene-3-carboxylic acid, 5,6-dihydro-2-(((ethylamino)thioxomethyl)amino)-, ethyl ester59898-48-5C13H18N2O2S2
- Ethyl 2-[(methoxycarbonyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate108611-69-4C12H15NO4S
- Dimethyl 2-(acetylamino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3,4-dicarboxylate369398-00-5C13H15NO5S
- 5-[(3-Ethoxycarbonyl-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)amino]-5-oxopentanoic acid342382-90-5C15H19NO5S
- Methyl 2-(ethoxycarbonylamino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate541543-83-3C12H15NO4S
- Methyl 2-(2,2-dimethylpropanoylcarbamothioylamino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate817570-38-0C15H20N2O3S2
- Methyl 2-(oxamoylamino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate838898-86-5C11H12N2O4S
- 2-(Propanoylamino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide301859-07-4C11H14N2O2S
- 4H-Cyclopenta(b)thiophene-2-carboxylic acid, 5,6-dihydro-3-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-, ethyl ester85462-71-1C16H25NO4S
- 4H-Cyclopenta(b)thiophene-2-carboxylic acid, 5,6-dihydro-3-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-, hydrochloride85462-73-3C14H22ClNO4S
- 2-Propanol, 1-((5,6-dihydro-4H-cyclopenta(b)thien-3-yl)oxy)-3-((1-methylethyl)amino)-, hydrochloride85462-74-4C13H22ClNO2S
- 4H-Cyclopenta(b)thiophene-2-carboxylic acid, 5,6-dihydro-3-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)-, ethyl ester85462-77-7C17H27NO4S
- 4H-Cyclopenta(b)thiophene-2-carboxylic acid, 5,6-dihydro-3-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)-, hydrochloride85462-86-8C15H24ClNO4S
- 2-Propanol, 1-((5,6-dihydro-4H-cyclopenta(b)thien-3-yl)oxy)-3-((1,1-dimethylethyl)amino)-, hydrochloride85462-91-5C14H24ClNO2S
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