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Murcko scaffold

Ring system with 2 rings and 12 atoms

42 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
12
Chemicals
42
With full pages
3
Scaffold SMILES

O=c1ncccn1C1CCCS1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1ncccn1C1CCCS1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 42 of 42 chemicals

2'-Deoxy-4'-thiocytidine chemical structure, C9H13N3O3S, CAS 134111-30-1
2'-Deoxy-4'-thiocytidine
CAS 134111-30-1C9H13N3O3S
Thiarabine chemical structure, C9H13N3O4S, CAS 26599-17-7
Thiarabine
CAS 26599-17-7C9H13N3O4S
2',3'-Dideoxy-4'-thiocytosine chemical structure, C9H13N3O2S, CAS 137719-36-9
2',3'-Dideoxy-4'-thiocytosine
CAS 137719-36-9C9H13N3O2S
4-Amino-5-fluoro-1-[(2R,5S)-5-(hydroxymethyl)tetrahydrothiophen-2-yl]pyrimidin-2-one chemical structure, C9H12FN3O2S, CAS 139031-42-8
4-Amino-5-fluoro-1-[(2R,5S)-5-(hydroxymethyl)tetrahydrothiophen-2-yl]pyrimidin-2-one
CAS 139031-42-8C9H12FN3O2S
4-Amino-1-[(2S,5R)-5-(hydroxymethyl)tetrahydrothiophen-2-yl]pyrimidin-2-one chemical structure, C9H13N3O2S, CAS 160963-03-1
4-Amino-1-[(2S,5R)-5-(hydroxymethyl)tetrahydrothiophen-2-yl]pyrimidin-2-one
CAS 160963-03-1C9H13N3O2S
4-Amino-5-fluoro-1-[(2S,5R)-5-(hydroxymethyl)tetrahydrothiophen-2-yl]pyrimidin-2-one chemical structure, C9H12FN3O2S, CAS 160963-17-7
4-Amino-5-fluoro-1-[(2S,5R)-5-(hydroxymethyl)tetrahydrothiophen-2-yl]pyrimidin-2-one
CAS 160963-17-7C9H12FN3O2S
4-Amino-1-[(2R,3R,5S)-3-fluoro-5-(hydroxymethyl)tetrahydrothiophen-2-yl]pyrimidin-2-one chemical structure, C9H12FN3O2S, CAS 166249-15-6
4-Amino-1-[(2R,3R,5S)-3-fluoro-5-(hydroxymethyl)tetrahydrothiophen-2-yl]pyrimidin-2-one
CAS 166249-15-6C9H12FN3O2S
4-Amino-1-[(2R,4S,5R)-4-fluoro-5-(hydroxymethyl)tetrahydrothiophen-2-yl]pyrimidin-2-one chemical structure, C9H12FN3O2S, CAS 166249-16-7
4-Amino-1-[(2R,4S,5R)-4-fluoro-5-(hydroxymethyl)tetrahydrothiophen-2-yl]pyrimidin-2-one
CAS 166249-16-7C9H12FN3O2S
4-Amino-1-[(2R,3R,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrothiophen-2-yl]pyrimidin-2-one chemical structure, C9H13N3O4S, CAS 208755-50-4
4-Amino-1-[(2R,3R,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrothiophen-2-yl]pyrimidin-2-one
CAS 208755-50-4C9H13N3O4S
4-Amino-1-[(2R,5R)-5-(hydroxymethyl)tetrahydrothiophen-2-yl]pyrimidin-2-one chemical structure, C9H13N3O2S, CAS 164200-65-1
4-Amino-1-[(2R,5R)-5-(hydroxymethyl)tetrahydrothiophen-2-yl]pyrimidin-2-one
CAS 164200-65-1C9H13N3O2S
4'-Thiogemcitabine chemical structure, C9H11F2N3O3S, CAS 174833-68-2
4'-Thiogemcitabine
CAS 174833-68-2C9H11F2N3O3S
2'-Deoxy-4'-C-methyl-4'-thioCytidine chemical structure, C10H15N3O3S, CAS 167948-11-0
2'-Deoxy-4'-C-methyl-4'-thioCytidine
CAS 167948-11-0C10H15N3O3S
1-(2-Deoxy-2-fluoro-4-thio-arabinofuranosyl)cytosine chemical structure, C9H12FN3O3S, CAS 184302-49-6
1-(2-Deoxy-2-fluoro-4-thio-arabinofuranosyl)cytosine
CAS 184302-49-6C9H12FN3O3S
4-Amino-1-[(2R,4R,5S)-4,5-bis(hydroxymethyl)tetrahydrothiophen-2-yl]pyrimidin-2-one chemical structure, C10H15N3O3S, CAS 154819-78-0
4-Amino-1-[(2R,4R,5S)-4,5-bis(hydroxymethyl)tetrahydrothiophen-2-yl]pyrimidin-2-one
CAS 154819-78-0C10H15N3O3S
4-Amino-5-fluoro-1-(4-thio-|A-D-arabinofuranosyl)-2(1H)-pyrimidinone chemical structure, C9H12FN3O4S, CAS 255396-12-4
4-Amino-5-fluoro-1-(4-thio-|A-D-arabinofuranosyl)-2(1H)-pyrimidinone
CAS 255396-12-4C9H12FN3O4S
4-Amino-1-(2-deoxy-2,2-difluoro-4-thio-|A-Derythro-pentofuranosyl)-2(1H)-pyrimidinone chemical structure, C9H11F2N3O3S, CAS 174833-69-3
4-Amino-1-(2-deoxy-2,2-difluoro-4-thio-|A-Derythro-pentofuranosyl)-2(1H)-pyrimidinone
CAS 174833-69-3C9H11F2N3O3S
4-Amino-5-chloro-1-(4-thio-|A-D-arabinofuranosyl)-2(1H)-pyrimidinone chemical structure, C9H12ClN3O4S, CAS 329022-29-9
4-Amino-5-chloro-1-(4-thio-|A-D-arabinofuranosyl)-2(1H)-pyrimidinone
CAS 329022-29-9C9H12ClN3O4S
2'-Azido-2'-deoxy-4'-thioCytidine chemical structure, C9H12N6O3S, CAS 189748-75-2
2'-Azido-2'-deoxy-4'-thioCytidine
CAS 189748-75-2C9H12N6O3S
4-Amino-5-methyl-1-(4-thio-|A-D-arabinofuranosyl)-2(1H)-pyrimidinone chemical structure, C10H15N3O4S, CAS 329022-25-5
4-Amino-5-methyl-1-(4-thio-|A-D-arabinofuranosyl)-2(1H)-pyrimidinone
CAS 329022-25-5C10H15N3O4S
5-Chloro-2'-deoxy-4'-thioCytidine chemical structure, C9H12ClN3O3S, CAS 174357-85-8
5-Chloro-2'-deoxy-4'-thioCytidine
CAS 174357-85-8C9H12ClN3O3S
2'-c-Methyl-4'-thiocytidine chemical structure, C10H15N3O4S, CAS 908128-93-8
2'-c-Methyl-4'-thiocytidine
CAS 908128-93-8C10H15N3O4S
4-Amino-1-(2-C-methyl-4-thio-|A-D-arabinofuranosyl)-2(1H)-pyrimidinone chemical structure, C10H15N3O4S, CAS 917249-01-5
4-Amino-1-(2-C-methyl-4-thio-|A-D-arabinofuranosyl)-2(1H)-pyrimidinone
CAS 917249-01-5C10H15N3O4S
4-Amino-1-(2-deoxy-4-thio-|A-D-erythro-pentofuranosyl)-2(1H)-pyrimidinone chemical structure, C9H13N3O3S, CAS 134111-40-3
4-Amino-1-(2-deoxy-4-thio-|A-D-erythro-pentofuranosyl)-2(1H)-pyrimidinone
CAS 134111-40-3C9H13N3O3S
Cytidine, 4'-thio- chemical structure, C9H13N3O4S, CAS 93080-09-2
Cytidine, 4'-thio-
CAS 93080-09-2C9H13N3O4S