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Murcko scaffold

4-Quinazolinol, 5,6,7,8-tetrahydro-2-(4-phenyl-1-piperazinyl)- scaffold

5 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
23
Chemicals
5
With full pages
3
Scaffold SMILES

O=c1[nH]c(N2CCN(c3ccccc3)CC2)nc2c1CCCC2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 4-Quinazolinol, 5,6,7,8-tetrahydro-2-(4-phenyl-1-piperazinyl)- page
Murcko scaffold O=c1[nH]c(N2CCN(c3ccccc3)CC2)nc2c1CCCC2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 5 of 5 chemicals

4-Quinazolinol, 5,6,7,8-tetrahydro-2-(4-phenyl-1-piperazinyl)- chemical structure, C18H22N4O, CAS 33017-98-0
4-Quinazolinol, 5,6,7,8-tetrahydro-2-(4-phenyl-1-piperazinyl)-
CAS 33017-98-0C18H22N4O
2-[4-(4-Methoxyphenyl)piperazin-1-yl]-5,6,7,8-tetrahydroquinazolin-4(3H)-one chemical structure, C19H24N4O2, CAS 878433-57-9
2-[4-(4-Methoxyphenyl)piperazin-1-yl]-5,6,7,8-tetrahydroquinazolin-4(3H)-one
CAS 878433-57-9C19H24N4O2
2-[4-(3-Chlorophenyl)piperazin-1-yl]-5,6,7,8-tetrahydro-3H-quinazolin-4-one chemical structure, C18H21ClN4O, CAS 942664-08-6
2-[4-(3-Chlorophenyl)piperazin-1-yl]-5,6,7,8-tetrahydro-3H-quinazolin-4-one
CAS 942664-08-6C18H21ClN4O
2-[4-(3-Methoxyphenyl)piperazinyl]-3,5,6,7,8-pentahydroquinazolin-4-one chemical structure, C19H24N4O2, CAS 924864-18-6
2-[4-(3-Methoxyphenyl)piperazinyl]-3,5,6,7,8-pentahydroquinazolin-4-one
CAS 924864-18-6C19H24N4O2
2-[4-(2-Methoxyphenyl)piperazin-1-yl]-5,6,7,8-tetrahydroquinazolin-4-ol chemical structure, C19H24N4O2, CAS 925643-44-3
2-[4-(2-Methoxyphenyl)piperazin-1-yl]-5,6,7,8-tetrahydroquinazolin-4-ol
CAS 925643-44-3C19H24N4O2