Murcko scaffold
Nampt-IN-12 scaffold
31 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 14
- Chemicals
- 31
- With full pages
- 3
Scaffold SMILES
O=C(Nc1cccs1)c1cccnc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 31 of 31 chemicals
N-(3-Carbamoyl-4,5-dimethylthiophen-2-yl)pyridine-3-carboxamide
CAS 328280-42-8C13H13N3O2S
Methyl 4,5-dimethyl-2-(3-pyridylcarbonylamino)thiophene-3-carboxylate
CAS 315696-54-9C14H14N2O3S
Ethyl 4,5-dimethyl-2-(pyridine-3-carbonylamino)thiophene-3-carboxylate
CAS 5694-42-8C15H16N2O3S
![4-Ethyl 2-methyl 3-methyl-5-[(pyridin-3-ylcarbonyl)amino]thiophene-2,4-dicarboxylate chemical structure, C16H16N2O5S, CAS 307324-70-5](/s/YMLUBXUSVZNJQP-UHFFFAOYSA-N.svg)
4-Ethyl 2-methyl 3-methyl-5-[(pyridin-3-ylcarbonyl)amino]thiophene-2,4-dicarboxylate
CAS 307324-70-5C16H16N2O5S
Methyl 4-cyano-3-methyl-5-(pyridine-3-carbonylamino)thiophene-2-carboxylate
CAS 461416-26-2C14H11N3O3S
Ethyl 4-ethyl-5-methyl-2-(pyridine-3-carbonylamino)thiophene-3-carboxylate
CAS 354547-33-4C16H18N2O3S
![Dimethyl 3-methyl-5-[(pyridin-3-ylcarbonyl)amino]thiophene-2,4-dicarboxylate chemical structure, C15H14N2O5S, CAS 352686-89-6](/s/YSTYNTZYIAYCMC-UHFFFAOYSA-N.svg)
Dimethyl 3-methyl-5-[(pyridin-3-ylcarbonyl)amino]thiophene-2,4-dicarboxylate
CAS 352686-89-6C15H14N2O5S
![Isopropyl 4,5-dimethyl-2-[(3-pyridinylcarbonyl)amino]-3-thiophenecarboxylate chemical structure, C16H18N2O3S, CAS 541529-77-5](/s/UYCHMUZVIFSFOV-UHFFFAOYSA-N.svg)
Isopropyl 4,5-dimethyl-2-[(3-pyridinylcarbonyl)amino]-3-thiophenecarboxylate
CAS 541529-77-5C16H18N2O3S
![Diethyl 5-[(5-bromopyridine-3-carbonyl)amino]-3-methylthiophene-2,4-dicarboxylate chemical structure, C17H17BrN2O5S, CAS 303031-51-8](/s/UDNFKSYRXHPMQB-UHFFFAOYSA-N.svg)
Diethyl 5-[(5-bromopyridine-3-carbonyl)amino]-3-methylthiophene-2,4-dicarboxylate
CAS 303031-51-8C17H17BrN2O5S
2-O-tert-Butyl 4-O-ethyl 3-methyl-5-(pyridine-3-carbonylamino)thiophene-2,4-dicarboxylate
CAS 545385-54-4C19H22N2O5S
Ethyl 5-(diethylcarbamoyl)-4-methyl-2-(pyridine-3-carbonylamino)thiophene-3-carboxylate
CAS 354550-51-9C19H23N3O4S
Diethyl 3-methyl-5-(nicotinamido)thiophene-2,4-dicarboxylate
CAS 303798-11-0C17H18N2O5S
![Dimethyl 5-[(2-chloropyridine-3-carbonyl)amino]-3-methylthiophene-2,4-dicarboxylate chemical structure, C15H13ClN2O5S, CAS 352677-60-2](/s/HNGPYFJFSAJIIE-UHFFFAOYSA-N.svg)
Dimethyl 5-[(2-chloropyridine-3-carbonyl)amino]-3-methylthiophene-2,4-dicarboxylate
CAS 352677-60-2C15H13ClN2O5S
![Ethyl 4-carbamoyl-5-[(2-chloropyridine-3-carbonyl)amino]-3-methylthiophene-2-carboxylate chemical structure, C15H14ClN3O4S, CAS 438615-68-0](/s/RTECDLFPSVJHAT-UHFFFAOYSA-N.svg)
Ethyl 4-carbamoyl-5-[(2-chloropyridine-3-carbonyl)amino]-3-methylthiophene-2-carboxylate
CAS 438615-68-0C15H14ClN3O4S
![Methyl 2-[(2-ethoxypyridine-3-carbonyl)amino]-4,5-dimethylthiophene-3-carboxylate chemical structure, C16H18N2O4S, CAS 353766-09-3](/s/WBOAEDFULRQTGS-UHFFFAOYSA-N.svg)
Methyl 2-[(2-ethoxypyridine-3-carbonyl)amino]-4,5-dimethylthiophene-3-carboxylate
CAS 353766-09-3C16H18N2O4S
Ethyl 5-propyl-2-(pyridine-3-carbonylamino)thiophene-3-carboxylate
CAS 717866-85-8C16H18N2O3S
![Isopropyl 5-[(diethylamino)carbonyl]-4-methyl-2-[(3-pyridinylcarbonyl)amino]-3-thiophenecarboxylate chemical structure, C20H25N3O4S, CAS 353765-73-8](/s/SGLYUQCAZDKXJE-UHFFFAOYSA-N.svg)
Isopropyl 5-[(diethylamino)carbonyl]-4-methyl-2-[(3-pyridinylcarbonyl)amino]-3-thiophenecarboxylate
CAS 353765-73-8C20H25N3O4S
N-(3-Carbamoylthiophen-2-yl)-2-(methylsulfanyl)pyridine-3-carboxamide
CAS 782460-89-3C12H11N3O2S2
![Ethyl 2-{[(5-bromopyridin-3-yl)carbonyl]amino}-4,5-dimethylthiophene-3-carboxylate chemical structure, C15H15BrN2O3S, CAS 303031-55-2](/s/HXGSXDGDNOTFLC-UHFFFAOYSA-N.svg)
Ethyl 2-{[(5-bromopyridin-3-yl)carbonyl]amino}-4,5-dimethylthiophene-3-carboxylate
CAS 303031-55-2C15H15BrN2O3S
N-(3-Carbamoylthiophen-2-yl)pyridine-3-carboxamide
CAS 895945-32-1C11H9N3O2S
5,6-Dichloro-N-(3-cyanothiophen-2-yl)pyridine-3-carboxamide
CAS 749914-59-8C11H5Cl2N3OS
![Methyl 2-[(2-chloropyridine-3-carbonyl)amino]-5-propan-2-ylthiophene-3-carboxylate chemical structure, C15H15ClN2O3S, CAS 445004-09-1](/s/ZMXFQLVGANMGPA-UHFFFAOYSA-N.svg)
Methyl 2-[(2-chloropyridine-3-carbonyl)amino]-5-propan-2-ylthiophene-3-carboxylate
CAS 445004-09-1C15H15ClN2O3S
![Methyl 4,5-dimethyl-2-[2-(methylsulfanyl)pyridine-3-amido]thiophene-3-carboxylate chemical structure, C15H16N2O3S2, CAS 939194-59-9](/s/UVETZXXQYHOQSU-UHFFFAOYSA-N.svg)
Methyl 4,5-dimethyl-2-[2-(methylsulfanyl)pyridine-3-amido]thiophene-3-carboxylate
CAS 939194-59-9C15H16N2O3S2
Ethyl 5-(methylethyl)-2-(3-pyridylcarbonylamino)thiophene-3-carboxylate
CAS 916039-60-6C16H18N2O3S
- Ethyl 2-(6-chloropyridine-3-amido)-4,5-dimethylthiophene-3-carboxylate930902-83-3C15H15ClN2O3S
- N-(3-Cyano-4,5-dimethylthiophen-2-yl)-2-(methylsulfanyl)pyridine-3-carboxamide1088211-55-5C14H13N3OS2
- 2-Chloro-N-(3-cyanothiophen-2-yl)pyridine-3-carboxamide1178378-73-8C11H6ClN3OS
- Ethyl 2-(5,6-dichloropyridine-3-amido)-4-methyl-5-(methylcarbamoyl)thiophene-3-carboxylate1259111-92-6C16H15Cl2N3O4S
- Methyl 2-(2,6-dichloro-5-fluoropyridine-3-amido)-4,5-dimethylthiophene-3-carboxylate1252288-54-2C14H11Cl2FN2O3S
- Nampt-IN-122427862-70-0C10H8N2OS
- Methyl 5-[(5-fluorosulfonyloxypyridine-3-carbonyl)amino]-3-methylthiophene-2-carboxylate2411306-38-0C13H11FN2O6S2
Related scaffolds
Same ring framework with different atoms or bond orders
O=C(Nc1ccccc1)c1ccco1208 chemicals
O=C(Nc1ccccc1)c1cccs1150 chemicals
O=C(Nc1nccs1)c1ccccc1121 chemicals![Scaffold O=C(N=c1[nH]ncs1)c1ccccc1](/scaffold/RWOUBULBQYRRNL-UHFFFAOYSA-N/structure.svg)
O=C(N=c1[nH]ncs1)c1ccccc187 chemicals
c1ccc(OCc2ccco2)cc175 chemicals
O=S(=O)(Nc1nccs1)c1ccccc161 chemicals![Scaffold c1ccc(CSc2ncn[nH]2)cc1](/scaffold/IQQYSQRJFHUASD-UHFFFAOYSA-N/structure.svg)
c1ccc(CSc2ncn[nH]2)cc160 chemicals![Scaffold O=C(Nc1ccccc1)c1cc[nH]n1](/scaffold/WMZYZYFPPQOFKY-UHFFFAOYSA-N/structure.svg)
O=C(Nc1ccccc1)c1cc[nH]n160 chemicals
O=C(Nc1cccs1)c1ccccc152 chemicals
O=C(Nc1ccccc1)C1CCCO150 chemicals
O=C(Nc1ccccc1)c1ccoc148 chemicals
c1ccc(CSc2nncs2)cc144 chemicals