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Murcko scaffold

3,4-Dihydro-1(2H)-quinolinyl(2-thienyl)methanone scaffold

42 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
17
Chemicals
42
With full pages
8
Scaffold SMILES

O=C(c1cccs1)N1CCCc2ccccc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 3,4-Dihydro-1(2H)-quinolinyl(2-thienyl)methanone page
Murcko scaffold O=C(c1cccs1)N1CCCc2ccccc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 42 of 42 chemicals

3,4-Dihydro-1(2H)-quinolinyl(2-thienyl)methanone chemical structure, C14H13NOS, CAS 330459-23-9
3,4-Dihydro-1(2H)-quinolinyl(2-thienyl)methanone
CAS 330459-23-9C14H13NOS
(6-Methyl-3,4-dihydro-2H-quinolin-1-yl)-thiophen-2-ylmethanone chemical structure, C15H15NOS, CAS 717855-52-2
(6-Methyl-3,4-dihydro-2H-quinolin-1-yl)-thiophen-2-ylmethanone
CAS 717855-52-2C15H15NOS
(3,4-Dihydroquinolin-1(2H)-yl)(5-nitrothiophen-2-yl)methanone chemical structure, C14H12N2O3S, CAS 793729-55-2
(3,4-Dihydroquinolin-1(2H)-yl)(5-nitrothiophen-2-yl)methanone
CAS 793729-55-2C14H12N2O3S
(2-Methyl-3,4-dihydroquinolin-1(2H)-yl)(thiophen-2-yl)methanone chemical structure, C15H15NOS, CAS 304643-44-5
(2-Methyl-3,4-dihydroquinolin-1(2H)-yl)(thiophen-2-yl)methanone
CAS 304643-44-5C15H15NOS
6-Fluoro-2-methyl-1-(2-thienylcarbonyl)-1,2,3,4-tetrahydroquinoline chemical structure, C15H14FNOS, CAS 440662-77-1
6-Fluoro-2-methyl-1-(2-thienylcarbonyl)-1,2,3,4-tetrahydroquinoline
CAS 440662-77-1C15H14FNOS
3-Chloro-2,2-dimethyl-N-[1-(thiophene-2-carbonyl)-1,2,3,4-tetrahydroquinolin-6-yl]propanamide chemical structure, C19H21ClN2O2S, CAS 1005305-81-6
3-Chloro-2,2-dimethyl-N-[1-(thiophene-2-carbonyl)-1,2,3,4-tetrahydroquinolin-6-yl]propanamide
CAS 1005305-81-6C19H21ClN2O2S
2-Methyl-N-[1-(thiophene-2-carbonyl)-3,4-dihydro-2H-quinolin-6-yl]propane-1-sulfonamide chemical structure, C18H22N2O3S2, CAS 1171464-91-7
2-Methyl-N-[1-(thiophene-2-carbonyl)-3,4-dihydro-2H-quinolin-6-yl]propane-1-sulfonamide
CAS 1171464-91-7C18H22N2O3S2
N-[1-(Thiophene-2-carbonyl)-3,4-dihydro-2H-quinolin-7-yl]butanamide chemical structure, C18H20N2O2S, CAS 946367-69-7
N-[1-(Thiophene-2-carbonyl)-3,4-dihydro-2H-quinolin-7-yl]butanamide
CAS 946367-69-7C18H20N2O2S
3,3-Dimethyl-N-(1-(thiophene-2-carbonyl)-1,2,3,4-tetrahydroquinolin-7-yl)butanamide chemical structure, C20H24N2O2S, CAS 946320-02-1
3,3-Dimethyl-N-(1-(thiophene-2-carbonyl)-1,2,3,4-tetrahydroquinolin-7-yl)butanamide
CAS 946320-02-1C20H24N2O2S
3-Methyl-N-[1-(thiophene-2-carbonyl)-1,2,3,4-tetrahydroquinolin-7-yl]butanamide chemical structure, C19H22N2O2S, CAS 946367-92-6
3-Methyl-N-[1-(thiophene-2-carbonyl)-1,2,3,4-tetrahydroquinolin-7-yl]butanamide
CAS 946367-92-6C19H22N2O2S
N-[1-(Thiophene-2-carbonyl)-1,2,3,4-tetrahydroquinolin-7-yl]acetamide chemical structure, C16H16N2O2S, CAS 946368-04-3
N-[1-(Thiophene-2-carbonyl)-1,2,3,4-tetrahydroquinolin-7-yl]acetamide
CAS 946368-04-3C16H16N2O2S
N-(1-(Thiophene-2-carbonyl)-1,2,3,4-tetrahydroquinolin-7-yl)pivalamide chemical structure, C19H22N2O2S, CAS 946368-08-7
N-(1-(Thiophene-2-carbonyl)-1,2,3,4-tetrahydroquinolin-7-yl)pivalamide
CAS 946368-08-7C19H22N2O2S
N-(1-(Thiophene-2-carbonyl)-1,2,3,4-tetrahydroquinolin-7-yl)propionamide chemical structure, C17H18N2O2S, CAS 946218-74-2
N-(1-(Thiophene-2-carbonyl)-1,2,3,4-tetrahydroquinolin-7-yl)propionamide
CAS 946218-74-2C17H18N2O2S
N-(1-(Thiophene-2-carbonyl)-1,2,3,4-tetrahydroquinolin-7-yl)isobutyramide chemical structure, C18H20N2O2S, CAS 946320-48-5
N-(1-(Thiophene-2-carbonyl)-1,2,3,4-tetrahydroquinolin-7-yl)isobutyramide
CAS 946320-48-5C18H20N2O2S
Ethyl (1-(thiophene-2-carbonyl)-1,2,3,4-tetrahydroquinolin-7-yl)carbamate chemical structure, C17H18N2O3S, CAS 955780-53-7
Ethyl (1-(thiophene-2-carbonyl)-1,2,3,4-tetrahydroquinolin-7-yl)carbamate
CAS 955780-53-7C17H18N2O3S
N-[1-(Thiophene-2-carbonyl)-3,4-dihydro-2H-quinolin-6-yl]methanesulfonamide chemical structure, C15H16N2O3S2, CAS 899945-45-0
N-[1-(Thiophene-2-carbonyl)-3,4-dihydro-2H-quinolin-6-yl]methanesulfonamide
CAS 899945-45-0C15H16N2O3S2
N-[1-(Thiophene-2-carbonyl)-3,4-dihydro-2H-quinolin-6-yl]ethanesulfonamide chemical structure, C16H18N2O3S2, CAS 941915-95-3
N-[1-(Thiophene-2-carbonyl)-3,4-dihydro-2H-quinolin-6-yl]ethanesulfonamide
CAS 941915-95-3C16H18N2O3S2
N-(1-(Thiophene-2-carbonyl)-1,2,3,4-tetrahydroquinolin-6-yl)butyramide chemical structure, C18H20N2O2S, CAS 899983-23-4
N-(1-(Thiophene-2-carbonyl)-1,2,3,4-tetrahydroquinolin-6-yl)butyramide
CAS 899983-23-4C18H20N2O2S
3,3-Dimethyl-N-[1-(thiophene-2-carbonyl)-1,2,3,4-tetrahydroquinolin-6-yl]butanamide chemical structure, C20H24N2O2S, CAS 899964-23-9
3,3-Dimethyl-N-[1-(thiophene-2-carbonyl)-1,2,3,4-tetrahydroquinolin-6-yl]butanamide
CAS 899964-23-9C20H24N2O2S
3-Methyl-N-[1-(thiophene-2-carbonyl)-3,4-dihydro-2H-quinolin-6-yl]butanamide chemical structure, C19H22N2O2S, CAS 899983-25-6
3-Methyl-N-[1-(thiophene-2-carbonyl)-3,4-dihydro-2H-quinolin-6-yl]butanamide
CAS 899983-25-6C19H22N2O2S
N-(1-(Thiophene-2-carbonyl)-1,2,3,4-tetrahydroquinolin-6-yl)acetamide chemical structure, C16H16N2O2S, CAS 899964-25-1
N-(1-(Thiophene-2-carbonyl)-1,2,3,4-tetrahydroquinolin-6-yl)acetamide
CAS 899964-25-1C16H16N2O2S
N-(1-(Thiophene-2-carbonyl)-1,2,3,4-tetrahydroquinolin-6-yl)pivalamide chemical structure, C19H22N2O2S, CAS 899735-57-0
N-(1-(Thiophene-2-carbonyl)-1,2,3,4-tetrahydroquinolin-6-yl)pivalamide
CAS 899735-57-0C19H22N2O2S
N-(1-(Thiophene-2-carbonyl)-1,2,3,4-tetrahydroquinolin-6-yl)propionamide chemical structure, C17H18N2O2S, CAS 899983-26-7
N-(1-(Thiophene-2-carbonyl)-1,2,3,4-tetrahydroquinolin-6-yl)propionamide
CAS 899983-26-7C17H18N2O2S
N-(1-(Thiophene-2-carbonyl)-1,2,3,4-tetrahydroquinolin-6-yl)isobutyramide chemical structure, C18H20N2O2S, CAS 899964-27-3
N-(1-(Thiophene-2-carbonyl)-1,2,3,4-tetrahydroquinolin-6-yl)isobutyramide
CAS 899964-27-3C18H20N2O2S