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Murcko scaffold

Ring system with 3 rings and 25 atoms

39 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
25
Chemicals
39
With full pages
2
Scaffold SMILES

O=C(COc1ccccc1)NCC(c1ccccc1)N1CCOCC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(COc1ccccc1)NCC(c1ccccc1)N1CCOCC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 39 of 39 chemicals

2-(4-Chlorophenoxy)-N-[2-(4-methoxyphenyl)-2-(morpholin-4-yl)ethyl]acetamide chemical structure, C21H25ClN2O4, CAS 142919-54-8
2-(4-Chlorophenoxy)-N-[2-(4-methoxyphenyl)-2-(morpholin-4-yl)ethyl]acetamide
CAS 142919-54-8C21H25ClN2O4
2-(4-Methoxyphenoxy)-N-[2-(4-methoxyphenyl)-2-(morpholin-4-yl)ethyl]acetamide chemical structure, C22H28N2O5, CAS 898490-06-7
2-(4-Methoxyphenoxy)-N-[2-(4-methoxyphenyl)-2-(morpholin-4-yl)ethyl]acetamide
CAS 898490-06-7C22H28N2O5
2-(3,5-Dimethylphenoxy)-N-[2-(4-methoxyphenyl)-2-(morpholin-4-yl)ethyl]acetamide chemical structure, C23H30N2O4, CAS 874356-84-0
2-(3,5-Dimethylphenoxy)-N-[2-(4-methoxyphenyl)-2-(morpholin-4-yl)ethyl]acetamide
CAS 874356-84-0C23H30N2O4
N-[2-(4-Chlorophenyl)-2-(morpholin-4-yl)ethyl]-2-phenoxyacetamide chemical structure, C20H23ClN2O3, CAS 898623-58-0
N-[2-(4-Chlorophenyl)-2-(morpholin-4-yl)ethyl]-2-phenoxyacetamide
CAS 898623-58-0C20H23ClN2O3
N-[2-(4-Chlorophenyl)-2-(morpholin-4-yl)ethyl]-2-(2-methoxyphenoxy)acetamide chemical structure, C21H25ClN2O4, CAS 898634-91-8
N-[2-(4-Chlorophenyl)-2-(morpholin-4-yl)ethyl]-2-(2-methoxyphenoxy)acetamide
CAS 898634-91-8C21H25ClN2O4
N-[2-(4-Chlorophenyl)-2-(morpholin-4-yl)ethyl]-2-(2-methylphenoxy)acetamide chemical structure, C21H25ClN2O3, CAS 898634-85-0
N-[2-(4-Chlorophenyl)-2-(morpholin-4-yl)ethyl]-2-(2-methylphenoxy)acetamide
CAS 898634-85-0C21H25ClN2O3
N-[2-(4-Chlorophenyl)-2-(morpholin-4-yl)ethyl]-2-(3,4-dimethylphenoxy)acetamide chemical structure, C22H27ClN2O3, CAS 898623-63-7
N-[2-(4-Chlorophenyl)-2-(morpholin-4-yl)ethyl]-2-(3,4-dimethylphenoxy)acetamide
CAS 898623-63-7C22H27ClN2O3
N-[2-(4-Chlorophenyl)-2-(morpholin-4-yl)ethyl]-2-[4-(propan-2-yl)phenoxy]acetamide chemical structure, C23H29ClN2O3, CAS 898623-56-8
N-[2-(4-Chlorophenyl)-2-(morpholin-4-yl)ethyl]-2-[4-(propan-2-yl)phenoxy]acetamide
CAS 898623-56-8C23H29ClN2O3
N-[2-(4-Methoxyphenyl)-2-(morpholin-4-yl)ethyl]-2-(4-methylphenoxy)acetamide chemical structure, C22H28N2O4, CAS 874401-00-0
N-[2-(4-Methoxyphenyl)-2-(morpholin-4-yl)ethyl]-2-(4-methylphenoxy)acetamide
CAS 874401-00-0C22H28N2O4
2-(4-Bromophenoxy)-N-[2-(4-methoxyphenyl)-2-(morpholin-4-yl)ethyl]acetamide chemical structure, C21H25BrN2O4, CAS 898490-10-3
2-(4-Bromophenoxy)-N-[2-(4-methoxyphenyl)-2-(morpholin-4-yl)ethyl]acetamide
CAS 898490-10-3C21H25BrN2O4
N-[2-(4-Methoxyphenyl)-2-morpholin-4-ylethyl]-2-(4-nitrophenoxy)acetamide chemical structure, C21H25N3O6, CAS 898490-15-8
N-[2-(4-Methoxyphenyl)-2-morpholin-4-ylethyl]-2-(4-nitrophenoxy)acetamide
CAS 898490-15-8C21H25N3O6
N-[2-(4-Methoxyphenyl)-2-morpholin-4-ylethyl]-2-phenoxyacetamide chemical structure, C21H26N2O4, CAS 898490-23-8
N-[2-(4-Methoxyphenyl)-2-morpholin-4-ylethyl]-2-phenoxyacetamide
CAS 898490-23-8C21H26N2O4
2-(4-Fluorophenoxy)-N-[2-(4-methoxyphenyl)-2-(morpholin-4-yl)ethyl]acetamide chemical structure, C21H25FN2O4, CAS 898491-81-1
2-(4-Fluorophenoxy)-N-[2-(4-methoxyphenyl)-2-(morpholin-4-yl)ethyl]acetamide
CAS 898491-81-1C21H25FN2O4
N-[2-(4-Chlorophenyl)-2-(morpholin-4-yl)ethyl]-2-(4-methoxyphenoxy)acetamide chemical structure, C21H25ClN2O4, CAS 898623-61-5
N-[2-(4-Chlorophenyl)-2-(morpholin-4-yl)ethyl]-2-(4-methoxyphenoxy)acetamide
CAS 898623-61-5C21H25ClN2O4
N-[2-(4-Chlorophenyl)-2-(morpholin-4-yl)ethyl]-2-(4-fluorophenoxy)acetamide chemical structure, C20H22ClFN2O3, CAS 898623-71-7
N-[2-(4-Chlorophenyl)-2-(morpholin-4-yl)ethyl]-2-(4-fluorophenoxy)acetamide
CAS 898623-71-7C20H22ClFN2O3
2-(4-Methoxyphenoxy)-N-(2-morpholino-2-(p-tolyl)ethyl)acetamide chemical structure, C22H28N2O4, CAS 898508-16-2
2-(4-Methoxyphenoxy)-N-(2-morpholino-2-(p-tolyl)ethyl)acetamide
CAS 898508-16-2C22H28N2O4
N-(2-(3-Methoxyphenyl)-2-morpholinoethyl)-2-phenoxyacetamide chemical structure, C21H26N2O4, CAS 942010-44-8
N-(2-(3-Methoxyphenyl)-2-morpholinoethyl)-2-phenoxyacetamide
CAS 942010-44-8C21H26N2O4
N-(2-(3-Methoxyphenyl)-2-morpholinoethyl)-2-(p-tolyloxy)acetamide chemical structure, C22H28N2O4, CAS 941940-59-6
N-(2-(3-Methoxyphenyl)-2-morpholinoethyl)-2-(p-tolyloxy)acetamide
CAS 941940-59-6C22H28N2O4
N-(2-(4-(Dimethylamino)phenyl)-2-morpholinoethyl)-2-(m-tolyloxy)acetamide chemical structure, C23H31N3O3, CAS 941949-24-2
N-(2-(4-(Dimethylamino)phenyl)-2-morpholinoethyl)-2-(m-tolyloxy)acetamide
CAS 941949-24-2C23H31N3O3
2-(2-Methoxyphenoxy)-N-(2-morpholino-2-(p-tolyl)ethyl)acetamide chemical structure, C22H28N2O4, CAS 941964-36-9
2-(2-Methoxyphenoxy)-N-(2-morpholino-2-(p-tolyl)ethyl)acetamide
CAS 941964-36-9C22H28N2O4
N-(2-(4-(Dimethylamino)phenyl)-2-morpholinoethyl)-2-(4-fluorophenoxy)acetamide chemical structure, C22H28FN3O3, CAS 941944-58-7
N-(2-(4-(Dimethylamino)phenyl)-2-morpholinoethyl)-2-(4-fluorophenoxy)acetamide
CAS 941944-58-7C22H28FN3O3
2-(2-Fluorophenoxy)-N-(2-(4-methoxyphenyl)-2-morpholinoethyl)acetamide chemical structure, C21H25FN2O4, CAS 941870-27-5
2-(2-Fluorophenoxy)-N-(2-(4-methoxyphenyl)-2-morpholinoethyl)acetamide
CAS 941870-27-5C21H25FN2O4
N-(2-(4-Fluorophenyl)-2-morpholinoethyl)-2-(2-methoxyphenoxy)acetamide chemical structure, C21H25FN2O4, CAS 941940-92-7
N-(2-(4-Fluorophenyl)-2-morpholinoethyl)-2-(2-methoxyphenoxy)acetamide
CAS 941940-92-7C21H25FN2O4
N-(2-(4-(Dimethylamino)phenyl)-2-morpholinoethyl)-2-(2-fluorophenoxy)acetamide chemical structure, C22H28FN3O3, CAS 1005305-26-9
N-(2-(4-(Dimethylamino)phenyl)-2-morpholinoethyl)-2-(2-fluorophenoxy)acetamide
CAS 1005305-26-9C22H28FN3O3