Murcko scaffold
RefChem:314157 scaffold
67 chemicals on CompoundList share this ring system.
- Rings
- 1
- Scaffold atoms
- 7
- Chemicals
- 67
- With full pages
- 5
Scaffold SMILES
C=C1C=CC=CN1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks. This is a very common single ring, so the list below is broad.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 67 chemicals
Ethyl 2-cyano-4-(1-methylpyridin-2(1H)-ylidene)but-2-enoate
CAS 57681-46-6C13H14N2O2
2-(1-Methyl-5-(trifluoromethyl)pyridin-2(1H)-ylidene)malononitrile
CAS 303018-13-5C10H6F3N3
Bas 00779692
CAS 778-50-7C11H8N4
Acetic acid, (1-methyl-2(1H)-pyridinylidene)-, methyl ester
CAS 39998-21-5C9H11NO2
2-(Amino(hydroxyimino)methyl)-1-methylpyridinium iodide
CAS 66168-51-2C7H10IN3O
Ethyl (E,4E)-2-cyano-4-(1-methyl-2-pyridinylidene)but-2-enoate
C13H14N2O2
Ethyl (E,4E)-2-cyano-4-(1-prop-2-enylpyridin-2-ylidene)but-2-enoate
CAS 57681-47-7C15H16N2O2
RefChem:314157
CAS 34037-14-4C6H7N
1-Methyl-2-(nitrosomethylidene)pyridine
CAS 60095-46-7C7H8N2O
Methyl 4-amino-5-cyano-6-(3-cyano-4-methoxy-4-oxobut-2-enylidene)-1-methylpyridine-3-carboxylate
C15H14N4O4
![Ethyl (6E)-4-amino-5-cyano-6-[(E)-3-cyano-4-ethoxy-4-oxobut-2-enylidene]-1-propylpyridine-3-carboxylate chemical structure, C19H22N4O4, CAS 68379-27-1](/s/IBZISWMGKWBLEP-ZHSNXSORSA-N.svg)
Ethyl (6E)-4-amino-5-cyano-6-[(E)-3-cyano-4-ethoxy-4-oxobut-2-enylidene]-1-propylpyridine-3-carboxylate
CAS 68379-27-1C19H22N4O4
Ethyl (2Z)-2-cyano-2-(1H-pyridin-2-ylidene)acetate
CAS 81991-30-2C10H10N2O2
2-(1,2-Dihydropyridin-2-ylidene)propanedinitrile
CAS 4664-21-5C8H5N3
![Methyl (6E)-4-amino-5-cyano-6-[(E)-3-cyano-4-methoxy-4-oxobut-2-enylidene]-1-methylpyridine-3-carboxylate chemical structure, C15H14N4O4, CAS 68350-77-6](/s/OSSZYIWMVDJMIM-XFRMRLMGSA-N.svg)
Methyl (6E)-4-amino-5-cyano-6-[(E)-3-cyano-4-methoxy-4-oxobut-2-enylidene]-1-methylpyridine-3-carboxylate
CAS 68350-77-6C15H14N4O4
![Methyl (6E)-4-amino-5-cyano-6-[(2E)-3-cyano-4-methoxy-4-oxobut-2-en-1-ylidene]-1-ethyl-1,6-dihydropyridine-3-carboxylate chemical structure, C16H16N4O4, CAS 68350-78-7](/s/RELWNLZSPOULMW-OTSXPSDFSA-N.svg)
Methyl (6E)-4-amino-5-cyano-6-[(2E)-3-cyano-4-methoxy-4-oxobut-2-en-1-ylidene]-1-ethyl-1,6-dihydropyridine-3-carboxylate
CAS 68350-78-7C16H16N4O4
![Methyl (6E)-4-amino-5-cyano-6-[(2E)-3-cyano-4-methoxy-4-oxobut-2-en-1-ylidene]-1-propyl-1,6-dihydropyridine-3-carboxylate chemical structure, C17H18N4O4, CAS 68418-94-0](/s/OHZUBQRHZQESAG-DYWAFWCTSA-N.svg)
Methyl (6E)-4-amino-5-cyano-6-[(2E)-3-cyano-4-methoxy-4-oxobut-2-en-1-ylidene]-1-propyl-1,6-dihydropyridine-3-carboxylate
CAS 68418-94-0C17H18N4O4
![[1-(2-Oxopropyl)pyridin-2(1H)-ylidene]propanedinitrile chemical structure, C11H9N3O, CAS 63014-71-1](/s/OXPSUVJSNAJINX-UHFFFAOYSA-N.svg)
[1-(2-Oxopropyl)pyridin-2(1H)-ylidene]propanedinitrile
CAS 63014-71-1C11H9N3O
4,6-Dimethyl-2-methylene-1,2-dihydropyridine
CAS 144486-77-1C8H11N
2-(Dicyanomethylidene)-6-methyl-1,2-dihydropyridin-3-yl acetate
CAS 93093-66-4C11H9N3O2
Ethyl 2-(5-bromopyridin-2-ylidene)-2-cyanoacetate
C10H9BrN2O2
(3E)-3-(6-Methyl-1H-pyridin-2-ylidene)prop-1-ene-1,1,3-tricarbonitrile
C12H8N4
Picolinaldehyde, oxime, 1-oxide
CAS 698-21-5C6H6N2O2
(6-Chloro-1-methylpyridin-2(1H)-ylidene)propanedinitrile
CAS 189242-53-3C9H6ClN3
![3-[(1Z)-1-(1-Hydroxy-2-pyridinylidene)ethyl]imino-1,1-dimethylthiourea chemical structure, C10H14N4OS, CAS 87587-01-7](/s/XIKVPEAAQLDJNN-RIWCBFQCSA-N.svg)
3-[(1Z)-1-(1-Hydroxy-2-pyridinylidene)ethyl]imino-1,1-dimethylthiourea
CAS 87587-01-7C10H14N4OS
- 2-Pyridineacetonitrile, 1,6-dihydro-6-methylene-732231-57-1C8H8N2
- 3,4,6-Trimethyl-2-methylidene-1H-pyridine144486-85-1C9H13N
- 2,3,4-Trimethyl-6-methylidene-1H-pyridine144486-82-8C9H13N
- 4-Methyl-2-methylene-1,2-dihydropyridine144486-76-0C7H9N
- 4-Pyridinecarboxamide, 1,2-dihydro-1-methyl-2-methylene-92777-79-2C8H10N2O
- (Z)-Methyl 2-cyano-2-(5-nitropyridin-2(1H)-ylidene)acetate1221794-83-7C9H7N3O4
- T-Butyl 2-cyano-2-(5-nitropyridin-2(1H)-ylidene)acetate1255574-90-3C12H13N3O4
- Ethyl 2-(5-bromopyridin-2(1H)-ylidene)-2-cyanoacetateC10H9BrN2O2
- tert-Butyl 2-cyano-2-(5-nitropyridin-2(1H)-ylidene)acetateC12H13N3O4
- [2-(1-Methoxypyridin-2(1H)-ylidene)ethylidene]propanedinitrile27352-34-7C11H9N3O
- Ethyl (2E,4Z)-4-[1-{[bis(methylsulfanyl)methylidene]amino}pyridin-2(1H)-ylidene]-2-cyanobut-2-enoate75619-85-1C15H17N3O2S2
- Ethyl 2-(5-bromopyridin-2(1H)-ylidene)-2-cyanoacetate103590-10-9C10H9BrN2O2
- [3-Chloro-5-trifluoromethyl-1H-pyridin-(2E)-ylidene]-cyano-acetic acid ethyl ester1300019-72-0C11H8ClF3N2O2
- (2Z)-2-(Prop-2-en-1-ylidene)-1,2-dihydropyridine70688-22-1C8H9N
- (2Z)-(Pyridin-2(1H)-ylidene)acetonitrile21963-20-2C7H6N2
- tert-Butyl (2Z)-2-cyano-2-(5-nitro-1H-pyridin-2-ylidene)acetateC12H13N3O4
- 3-(6-Methylpyridin-2(1H)-ylidene)prop-1-ene-1,1,3-tricarbonitrile113525-73-8C12H8N4
- Ethyl 3-(1-hydroxypyridin-2(1H)-ylidene)-2-oxopropanoate143814-23-7C10H11NO4
- 3-{[(Pyridin-2(1H)-ylidene)methyl]sulfanyl}propane-1,2-diol189316-43-6C9H13NO2S
- 2-(1-Nitrosoethylidene)pyridin-1(2H)-ol2116-70-3C7H8N2O2
- 1-Methyl-2-(propan-2-ylidene)-1,2-dihydropyridine63438-29-9C9H13N
- 4-Nitro-2-(nitrosomethylidene)pyridin-1(2H)-ol63097-29-0C6H5N3O4
- 3-{2-[1-(Prop-2-en-1-yl)pyridin-2(1H)-ylidene]ethylidene}pentane-2,4-dione62062-35-5C15H17NO2
- 3-[2-(1,6-Dimethylpyridin-2(1H)-ylidene)ethylidene]pentane-2,4-dione62062-34-4C14H17NO2
Related scaffolds
Same ring framework with different atoms or bond orders
![Scaffold O=c1cccc[nH]1](/scaffold/UBQKCCHYAOITMY-UHFFFAOYSA-N/structure.svg)
