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Murcko scaffold

Ring system with 3 rings and 18 atoms

20 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 18
Chemicals: 20
With full pages: 6

Scaffold SMILES

O=c1n(-c2ccccc2)cnn1-c1ccccn1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=c1n(-c2ccccc2)cnn1-c1ccccn1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 20 of 20 chemicals

2-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-4-(4-isopropylphenyl)-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one chemical structure, C18H16ClF3N4O, CAS 860785-30-4

2-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-4-(4-isopropylphenyl)-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one

CAS 860785-30-4C₁₈H₁₆ClF₃N₄O

4-(4-Isopropylphenyl)-2-(3-nitro-2-pyridinyl)-2,4-dihydro-3H-1,2,4-triazol-3-one chemical structure, C16H15N5O3, CAS 343373-31-9

4-(4-Isopropylphenyl)-2-(3-nitro-2-pyridinyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

CAS 343373-31-9C₁₆H₁₅N₅O₃

4-(4-Bromophenyl)-2-(3-nitro-2-pyridinyl)-2,4-dihydro-3H-1,2,4-triazol-3-one chemical structure, C13H8BrN5O3, CAS 343373-33-1

4-(4-Bromophenyl)-2-(3-nitro-2-pyridinyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

CAS 343373-33-1C₁₃H₈BrN₅O₃

4-[4-(tert-Butyl)phenyl]-2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one chemical structure, C19H18ClF3N4O, CAS 860612-54-0

4-[4-(tert-Butyl)phenyl]-2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one

CAS 860612-54-0C₁₉H₁₈ClF₃N₄O

4-(4-Bromophenyl)-2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-5-methyl-1,2,4-triazol-3-one chemical structure, C15H9BrClF3N4O, CAS 860644-56-0

4-(4-Bromophenyl)-2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-5-methyl-1,2,4-triazol-3-one

CAS 860644-56-0C₁₅H₉BrClF₃N₄O

2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-4-(3-methoxyphenyl)-5-methyl-1,2,4-triazol-3-one chemical structure, C16H12ClF3N4O2, CAS 860786-24-9

2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-4-(3-methoxyphenyl)-5-methyl-1,2,4-triazol-3-one

CAS 860786-24-9C₁₆H₁₂ClF₃N₄O₂

2-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-4-(4-methoxyphenyl)-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one chemical structure, C16H12ClF3N4O2, CAS 861206-12-4

2-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-4-(4-methoxyphenyl)-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one

CAS 861206-12-4C₁₆H₁₂ClF₃N₄O₂

2-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-4-(2,6-dimethylphenyl)-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one chemical structure, C17H14ClF3N4O, CAS 860789-14-6

2-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-4-(2,6-dimethylphenyl)-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one

CAS 860789-14-6C₁₇H₁₄ClF₃N₄O

2-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-5-methyl-4-phenyl-2,4-dihydro-3H-1,2,4-triazol-3-one chemical structure, C15H10ClF3N4O, CAS 860789-81-7

2-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-5-methyl-4-phenyl-2,4-dihydro-3H-1,2,4-triazol-3-one

CAS 860789-81-7C₁₅H₁₀ClF₃N₄O

4-(2-Chlorophenyl)-2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one chemical structure, C15H9Cl2F3N4O, CAS 860789-87-3

4-(2-Chlorophenyl)-2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one

CAS 860789-87-3C₁₅H₉Cl₂F₃N₄O

4-(4-Chlorophenyl)-2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one chemical structure, C15H9Cl2F3N4O, CAS 860786-59-0

4-(4-Chlorophenyl)-2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one

CAS 860786-59-0C₁₅H₉Cl₂F₃N₄O

2-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-5-methyl-4-(4-methylphenyl)-1,2,4-triazol-3-one chemical structure, C16H12ClF3N4O, CAS 860789-68-0

2-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-5-methyl-4-(4-methylphenyl)-1,2,4-triazol-3-one

CAS 860789-68-0C₁₆H₁₂ClF₃N₄O

2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-4-(2,6-difluorophenyl)-5-methyl-1,2,4-triazol-3-one chemical structure, C15H8ClF5N4O, CAS 861206-32-8

2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-4-(2,6-difluorophenyl)-5-methyl-1,2,4-triazol-3-one

CAS 861206-32-8C₁₅H₈ClF₅N₄O

2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-4-(2,4-dimethoxyphenyl)-5-methyl-1,2,4-triazol-3-one chemical structure, C17H14ClF3N4O3, CAS 861206-40-8

2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-4-(2,4-dimethoxyphenyl)-5-methyl-1,2,4-triazol-3-one

CAS 861206-40-8C₁₇H₁₄ClF₃N₄O₃

4-(3-Chlorophenyl)-2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one chemical structure, C15H9Cl2F3N4O, CAS 860786-38-5

4-(3-Chlorophenyl)-2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one

CAS 860786-38-5C₁₅H₉Cl₂F₃N₄O

2-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-4-(3-fluorophenyl)-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one chemical structure, C15H9ClF4N4O, CAS 860786-22-7

2-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-4-(3-fluorophenyl)-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one

CAS 860786-22-7C₁₅H₉ClF₄N₄O

2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-5-methyl-4-[3-(trifluoromethyl)phenyl]-1,2,4-triazol-3-one chemical structure, C16H9ClF6N4O, CAS 861206-72-6

2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-5-methyl-4-[3-(trifluoromethyl)phenyl]-1,2,4-triazol-3-one

CAS 861206-72-6C₁₆H₉ClF₆N₄O

2-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-4-(4-fluorophenyl)-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one chemical structure, C15H9ClF4N4O, CAS 860784-96-9

2-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-4-(4-fluorophenyl)-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one

CAS 860784-96-9C₁₅H₉ClF₄N₄O

2-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-4-(2-fluorophenyl)-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one chemical structure, C15H9ClF4N4O, CAS 860786-73-8

2-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-4-(2-fluorophenyl)-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one

CAS 860786-73-8C₁₅H₉ClF₄N₄O

2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-4-[3-(trifluoromethyl)phenyl]-1,2,4-triazol-3-one chemical structure, C15H7ClF6N4O, CAS 343373-37-5

2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-4-[3-(trifluoromethyl)phenyl]-1,2,4-triazol-3-one

CAS 343373-37-5C₁₅H₇ClF₆N₄O