Murcko scaffold
Ring system with 2 rings and 10 atoms
48 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 10
- Chemicals
- 48
- With full pages
- 3
Scaffold SMILES
c1cc2c(cn1)OCCO2
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 48 chemicals
![7-Ethenyl-2,3-dihydro[1,4]dioxino[2,3-c]pyridine chemical structure, C9H9NO2, CAS 477788-04-8](/s/WWHICBVKJYFFSG-UHFFFAOYSA-N.svg)
7-Ethenyl-2,3-dihydro[1,4]dioxino[2,3-c]pyridine
CAS 477788-04-8C9H9NO2
![1-(2,3-Dihydro[1,4]dioxino[2,3-c]pyridin-7-yl)-2-(trimethylsilyl)ethanol chemical structure, C12H19NO3Si, CAS 477788-03-7](/s/KATXLQRXWHBXJL-UHFFFAOYSA-N.svg)
1-(2,3-Dihydro[1,4]dioxino[2,3-c]pyridin-7-yl)-2-(trimethylsilyl)ethanol
CAS 477788-03-7C12H19NO3Si
![(2,3-Dihydro-[1,4]dioxino[2,3-c]pyridin-5-yl)methanol chemical structure, C8H9NO3, CAS 139645-12-8](/s/SRYDSVKMASXIBR-UHFFFAOYSA-N.svg)
(2,3-Dihydro-[1,4]dioxino[2,3-c]pyridin-5-yl)methanol
CAS 139645-12-8C8H9NO3
2H,3H-(1,4)Dioxino(2,3-c)pyridine-7-carboxylic acid
CAS 527681-13-6C8H7NO4
![2,3-Dihydro[1,4]dioxino[2,3-c]pyridine-7-carbaldehyde chemical structure, C8H7NO3, CAS 443955-90-6](/s/OMWBUWDHEZIMGQ-UHFFFAOYSA-N.svg)
2,3-Dihydro[1,4]dioxino[2,3-c]pyridine-7-carbaldehyde
CAS 443955-90-6C8H7NO3
![(2,3-Dihydro-[1,4]dioxino[2,3-c]pyridin-7-yl)methanol chemical structure, C8H9NO3, CAS 443955-89-3](/s/MTZSLQPBGNIKBC-UHFFFAOYSA-N.svg)
(2,3-Dihydro-[1,4]dioxino[2,3-c]pyridin-7-yl)methanol
CAS 443955-89-3C8H9NO3
![8-Chloro-2,3-dihydro-1,4-dioxino[2,3-c]pyridine-7-carboxaldehyde chemical structure, C8H6ClNO3, CAS 1402134-92-2](/s/PJBKBJMBLCSOOL-UHFFFAOYSA-N.svg)
8-Chloro-2,3-dihydro-1,4-dioxino[2,3-c]pyridine-7-carboxaldehyde
CAS 1402134-92-2C8H6ClNO3
![Methyl 2,3-dihydro-[1,4]dioxino[2,3-c]pyridine-7-carboxylate chemical structure, C9H9NO4, CAS 527681-12-5](/s/JIVCFASCQPHPEL-UHFFFAOYSA-N.svg)
Methyl 2,3-dihydro-[1,4]dioxino[2,3-c]pyridine-7-carboxylate
CAS 527681-12-5C9H9NO4
![7-Methyl-2,3-dihydro-[1,4]dioxino[2,3-c]pyridine chemical structure, C8H9NO2, CAS 724791-41-7](/s/SVXJJZDKSRCIFN-UHFFFAOYSA-N.svg)
7-Methyl-2,3-dihydro-[1,4]dioxino[2,3-c]pyridine
CAS 724791-41-7C8H9NO2
![2H,3H-[1,4]Dioxino[2,3-c]pyridin-5-amine chemical structure, C7H8N2O2, CAS 2748455-32-3](/s/VZJGFKVHMFTZDB-UHFFFAOYSA-N.svg)
2H,3H-[1,4]Dioxino[2,3-c]pyridin-5-amine
CAS 2748455-32-3C7H8N2O2
![7-(Azidomethyl)-2H,3H-[1,4]dioxino[2,3-c]pyridine chemical structure, C8H8N4O2, CAS 917836-00-1](/s/XJINVGQHXCHUKL-UHFFFAOYSA-N.svg)
7-(Azidomethyl)-2H,3H-[1,4]dioxino[2,3-c]pyridine
CAS 917836-00-1C8H8N4O2
![1-(2,3-Dihydro-1,4-dioxino[2,3-c]pyridin-7-yl)ethanone chemical structure, C9H9NO3, CAS 1198167-39-3](/s/MMFFFZBMOIDEOE-UHFFFAOYSA-N.svg)
1-(2,3-Dihydro-1,4-dioxino[2,3-c]pyridin-7-yl)ethanone
CAS 1198167-39-3C9H9NO3
![(2,3-Dihydro-[1,4]dioxino[2,3-c]pyridin-7-yl)-carbamic acid tert-butyl ester chemical structure, C12H16N2O4, CAS 1185181-65-0](/s/GAQWYDHMVWSGMF-UHFFFAOYSA-N.svg)
(2,3-Dihydro-[1,4]dioxino[2,3-c]pyridin-7-yl)-carbamic acid tert-butyl ester
CAS 1185181-65-0C12H16N2O4
![7-(Chloromethyl)-2H,3H-[1,4]dioxino[2,3-c]pyridine hydrochloride chemical structure, C8H9Cl2NO2, CAS 917835-99-5](/s/RFLAKYTXZYYVHY-UHFFFAOYSA-N.svg)
7-(Chloromethyl)-2H,3H-[1,4]dioxino[2,3-c]pyridine hydrochloride
CAS 917835-99-5C8H9Cl2NO2
![5-Iodo-2,3-dihydro-[1,4]dioxino[2,3-c]pyridine chemical structure, C7H6INO2, CAS 1383788-23-5](/s/INOYPKYZCUYXND-UHFFFAOYSA-N.svg)
5-Iodo-2,3-dihydro-[1,4]dioxino[2,3-c]pyridine
CAS 1383788-23-5C7H6INO2
![2H,3H-[1,4]Dioxino[2,3-c]pyridine-5-carboxylic acid chemical structure, C8H7NO4, CAS 1369334-25-7](/s/GKNLAJCBTWRKHY-UHFFFAOYSA-N.svg)
2H,3H-[1,4]Dioxino[2,3-c]pyridine-5-carboxylic acid
CAS 1369334-25-7C8H7NO4
![(2,3-Dihydro-[1,4]dioxino[2,3-c]pyridin-7-yl)methanamine hydrochloride chemical structure, C8H11ClN2O2, CAS 917836-01-2](/s/DFONVPXIYNQGKJ-UHFFFAOYSA-N.svg)
(2,3-Dihydro-[1,4]dioxino[2,3-c]pyridin-7-yl)methanamine hydrochloride
CAS 917836-01-2C8H11ClN2O2
![N-Methoxy-N-methyl-2,3-dihydro-[1,4]dioxino[2,3-c]pyridine-7-carboxamide chemical structure, C10H12N2O4, CAS 1229515-16-5](/s/KRXDOWRSLYBNMV-UHFFFAOYSA-N.svg)
N-Methoxy-N-methyl-2,3-dihydro-[1,4]dioxino[2,3-c]pyridine-7-carboxamide
CAS 1229515-16-5C10H12N2O4
![8-Bromo-5-methyl-2,3-dihydro-[1,4]dioxino[2,3-c]pyridine chemical structure, C8H8BrNO2, CAS 1469976-40-6](/s/SQBWVTKEPOHMGK-UHFFFAOYSA-N.svg)
8-Bromo-5-methyl-2,3-dihydro-[1,4]dioxino[2,3-c]pyridine
CAS 1469976-40-6C8H8BrNO2
![2,3-Dihydro-[1,4]dioxino[2,3-c]pyridin-7-amine chemical structure, C7H8N2O2, CAS 873533-86-9](/s/COLBAQULYZQSND-UHFFFAOYSA-N.svg)
2,3-Dihydro-[1,4]dioxino[2,3-c]pyridin-7-amine
CAS 873533-86-9C7H8N2O2
![2,3-Dihydro-[1,4]dioxino[2,3-c]pyridine-5-carbaldehyde chemical structure, C8H7NO3, CAS 1414864-13-3](/s/GLSFTEHWRXUJBK-UHFFFAOYSA-N.svg)
2,3-Dihydro-[1,4]dioxino[2,3-c]pyridine-5-carbaldehyde
CAS 1414864-13-3C8H7NO3
![2,3-Dihydro-[1,4]dioxino-[2,3-c]pyridine-5-carbonitrile chemical structure, C8H6N2O2, CAS 1823922-75-3](/s/HGYCKKOLUNSWIW-UHFFFAOYSA-N.svg)
2,3-Dihydro-[1,4]dioxino-[2,3-c]pyridine-5-carbonitrile
CAS 1823922-75-3C8H6N2O2
![tert-Butyl ((2,3-dihydro-[1,4]dioxino-[2,3-c]pyridin-5-yl)methyl)carbamate chemical structure, C13H18N2O4, CAS 1823832-57-0](/s/GNTZUSGDSGJROG-UHFFFAOYSA-N.svg)
tert-Butyl ((2,3-dihydro-[1,4]dioxino-[2,3-c]pyridin-5-yl)methyl)carbamate
CAS 1823832-57-0C13H18N2O4
![5-Iodo-2,3-dihydro-[1,4]dioxino-[2,3-c]pyridine-8-carbaldehyde chemical structure, C8H6INO3, CAS 1823955-13-0](/s/HZGFUESCMWPFIK-UHFFFAOYSA-N.svg)
5-Iodo-2,3-dihydro-[1,4]dioxino-[2,3-c]pyridine-8-carbaldehyde
CAS 1823955-13-0C8H6INO3
- 2H,3H-[1,4]Dioxino[2,3-c]pyridin-7-amine hydrochloride1909347-84-7C7H9ClN2O2
- 7-Bromo-2,3-dihydro-[1,4]dioxino[2,3-c]pyridine2079950-83-5C7H6BrNO2
- {2H,3H-[1,4]Dioxino[2,3-c]pyridin-7-yl}methanamine dihydrochloride2059932-02-2C8H12Cl2N2O2
- 2,3-Dihydro[1,4]dioxino[2,3-c]pyridine-7-carboxylic acid hydrochloride2169997-52-6C8H8ClNO4
- 2-(2,3-Dihydro-[1,4]dioxino[2,3-c]pyridin-7-yl)-2,2-difluoro-ethanol2230727-40-7C9H9F2NO3
- (2E)-4-(Dimethylamino)-N-({2H,3H-[1,4]dioxino[2,3-c]pyridin-7-yl}methyl)but-2-enamide2411337-04-5C14H19N3O3
- N-(2,3-Dihydro-[1,4]dioxino[2,3-c]pyridin-7-ylmethyl)but-2-ynamide2411271-05-9C12H12N2O3
- 2,3-Dihydro-[1,4]dioxino[2,3-c]pyridine-7-carbonitrile2168453-30-1C8H6N2O2
- 7-(1-Fluoro-2-iodovinyl)-2,3-dihydro-[1,4]dioxino[2,3-c]pyridine2306281-14-9C9H7FINO2
- 7-Chloro-2,2,3,3-tetradeuterio-8-fluoro-[1,4]dioxino[2,3-c]pyridine2380314-81-6C7H5ClFNO2
- 2,2-Difluoro-3H-[1,4]dioxino[2,3-c]pyridine-7-carboxylic acid2380313-63-1C8H5F2NO4
- (2S)-2-Fluoro-2,3-dihydro-[1,4]dioxino[2,3-c]pyridine-7-carboxylic acid2380314-67-8C8H6FNO4
- 8-Chloro-2,3-dihydro-[1,4]dioxino[2,3-c]pyridine-7-carboxylic acid2380313-57-3C8H6ClNO4
- 2,2,3,3-Tetradeuterio-8-fluoro-[1,4]dioxino[2,3-c]pyridine-7-carboxylic acid2380314-83-8C8H6FNO4
- 3,3-Difluoro-2H-[1,4]dioxino[2,3-c]pyridine-7-carboxylic acid2380313-67-5C8H5F2NO4
- Methyl 2,2,3,3-tetradeuterio-8-fluoro-[1,4]dioxino[2,3-c]pyridine-7-carboxylate2380314-82-7C9H8FNO4
- 2-Chloro-N-({2H,3H-[1,4]dioxino[2,3-c]pyridin-7-yl}methyl)acetamide2411219-29-7C10H11ClN2O3
- 5-Bromo-7-methylsulfonyl-2,3-dihydro-[1,4]dioxino[2,3-c]pyridine2757008-34-5C8H8BrNO4S
- 5-Bromo-7-methylsulfanyl-2,3-dihydro-[1,4]dioxino[2,3-c]pyridine2757008-37-8C8H8BrNO2S
- 5-Bromo-7-iodo-2,3-dihydro-[1,4]dioxino[2,3-c]pyridine2757008-36-7C7H5BrINO2
- 5-Bromo-2H,3H-[1,4]dioxino[2,3-c]pyridine2995291-93-3C7H6BrNO2
- 5-Bromo-7-iodo-2,3-dimethyl-2,3-dihydro-[1,4]dioxino[2,3-c]pyridine3064470-21-6C9H9BrINO2
- Methyl 8-bromo-2,3-dihydro-[1,4]dioxino[2,3-c]pyridine-5-carboxylate3052542-22-7C9H8BrNO4
- Sodium 2H,3H-[1,4]dioxino[2,3-c]pyridine-5-carboxylate3017263-91-8C8H6NNaO4
Related scaffolds
Same ring framework with different atoms or bond orders
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