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Murcko scaffold

Ring system with 2 rings and 12 atoms

8 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
12
Chemicals
8
With full pages
5
Scaffold SMILES

O=C1NC=CC(c2ccsc2)N1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1NC=CC(c2ccsc2)N1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 8 of 8 chemicals

Methyl 6-methyl-2-oxo-4-(thiophen-3-yl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate chemical structure, C11H12N2O3S, CAS 421578-54-3
Methyl 6-methyl-2-oxo-4-(thiophen-3-yl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS 421578-54-3C11H12N2O3S
Ethyl (4R)-6-methyl-2-oxo-4-thiophen-3-yl-3,4-dihydro-1H-pyrimidine-5-carboxylate chemical structure, C12H14N2O3S, CAS 2718132-03-5
Ethyl (4R)-6-methyl-2-oxo-4-thiophen-3-yl-3,4-dihydro-1H-pyrimidine-5-carboxylate
CAS 2718132-03-5C12H14N2O3S
Ethyl 6-methyl-2-oxo-4-(thiophen-3-yl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate chemical structure, C12H14N2O3S, CAS 352692-70-7
Ethyl 6-methyl-2-oxo-4-(thiophen-3-yl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS 352692-70-7C12H14N2O3S
1,6-Dimethyl-2-oxo-4-thiophen-3-yl-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid isopropyl ester chemical structure, C14H18N2O3S, CAS 306286-56-6
1,6-Dimethyl-2-oxo-4-thiophen-3-yl-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid isopropyl ester
CAS 306286-56-6C14H18N2O3S
Methyl 1,6-dimethyl-2-oxo-4-(3-thienyl)-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate chemical structure, C12H14N2O3S, CAS 354784-67-1
Methyl 1,6-dimethyl-2-oxo-4-(3-thienyl)-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate
CAS 354784-67-1C12H14N2O3S
5-Pyrimidinecarboxylic acid,1,2,3,4-tetrahydro-6-methyl-2-oxo-4-(3-thienyl)-,2-methylpropyl ester chemical structure, C14H18N2O3S, CAS 568568-16-1
5-Pyrimidinecarboxylic acid,1,2,3,4-tetrahydro-6-methyl-2-oxo-4-(3-thienyl)-,2-methylpropyl ester
CAS 568568-16-1C14H18N2O3S
Ethyl 1,6-dimethyl-2-oxo-4-(thiophen-3-yl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate chemical structure, C13H16N2O3S, CAS 1061865-00-6
Ethyl 1,6-dimethyl-2-oxo-4-(thiophen-3-yl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS 1061865-00-6C13H16N2O3S
5-Acetyl-6-methyl-4-(thiophen-3-yl)-3,4-dihydropyrimidin-2(1H)-one chemical structure, C11H12N2O2S, CAS 423153-18-8
5-Acetyl-6-methyl-4-(thiophen-3-yl)-3,4-dihydropyrimidin-2(1H)-one
CAS 423153-18-8C11H12N2O2S