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Murcko scaffold

Ring system with 4 rings and 27 atoms

50 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
27
Chemicals
50
With full pages
4
Scaffold SMILES

O=C(Cn1ccn2nc(-c3ccccc3)cc2c1=O)NCc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Cn1ccn2nc(-c3ccccc3)cc2c1=O)NCc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 50 chemicals

N-Benzyl-2-[2-(4-ethoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]acetamide chemical structure, C23H22N4O3, CAS 941981-45-9
N-Benzyl-2-[2-(4-ethoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]acetamide
CAS 941981-45-9C23H22N4O3
2-[2-(4-Ethoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(4-methylbenzyl)acetamide chemical structure, C24H24N4O3, CAS 941938-55-2
2-[2-(4-Ethoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(4-methylbenzyl)acetamide
CAS 941938-55-2C24H24N4O3
N-(4-Chlorobenzyl)-2-[2-(4-ethoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]acetamide chemical structure, C23H21ClN4O3, CAS 941876-62-6
N-(4-Chlorobenzyl)-2-[2-(4-ethoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]acetamide
CAS 941876-62-6C23H21ClN4O3
2-[2-(4-Ethoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(4-fluorobenzyl)acetamide chemical structure, C23H21FN4O3, CAS 941981-47-1
2-[2-(4-Ethoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(4-fluorobenzyl)acetamide
CAS 941981-47-1C23H21FN4O3
2-[2-(4-Ethoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(4-methoxybenzyl)acetamide chemical structure, C24H24N4O4, CAS 941938-56-3
2-[2-(4-Ethoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(4-methoxybenzyl)acetamide
CAS 941938-56-3C24H24N4O4
N-(4-Methylbenzyl)-2-(4-oxo-2-phenylpyrazolo[1,5-a]pyrazin-5(4H)-yl)acetamide chemical structure, C22H20N4O2, CAS 941920-52-1
N-(4-Methylbenzyl)-2-(4-oxo-2-phenylpyrazolo[1,5-a]pyrazin-5(4H)-yl)acetamide
CAS 941920-52-1C22H20N4O2
N-Benzyl-2-[2-(4-methylphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]acetamide chemical structure, C22H20N4O2, CAS 941894-67-3
N-Benzyl-2-[2-(4-methylphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]acetamide
CAS 941894-67-3C22H20N4O2
N-Benzyl-2-[2-(4-methoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]acetamide chemical structure, C22H20N4O3, CAS 941876-17-1
N-Benzyl-2-[2-(4-methoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]acetamide
CAS 941876-17-1C22H20N4O3
2-[2-(4-Methoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(4-methylbenzyl)acetamide chemical structure, C23H22N4O3, CAS 941980-97-8
2-[2-(4-Methoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(4-methylbenzyl)acetamide
CAS 941980-97-8C23H22N4O3
N-(4-Chlorobenzyl)-2-[2-(4-methoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]acetamide chemical structure, C22H19ClN4O3, CAS 941938-31-4
N-(4-Chlorobenzyl)-2-[2-(4-methoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]acetamide
CAS 941938-31-4C22H19ClN4O3
N-(2-Methoxybenzyl)-2-[2-(4-methoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]acetamide chemical structure, C23H22N4O4, CAS 941876-23-9
N-(2-Methoxybenzyl)-2-[2-(4-methoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]acetamide
CAS 941876-23-9C23H22N4O4
2-(2-(4-Butoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl)-N-(4-methylbenzyl)acetamide chemical structure, C26H28N4O3, CAS 941886-85-7
2-(2-(4-Butoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl)-N-(4-methylbenzyl)acetamide
CAS 941886-85-7C26H28N4O3
N-Benzyl-2-(2-(4-butoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl)acetamide chemical structure, C25H26N4O3, CAS 941977-50-0
N-Benzyl-2-(2-(4-butoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl)acetamide
CAS 941977-50-0C25H26N4O3
2-(2-(4-Butoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl)-N-(4-chlorobenzyl)acetamide chemical structure, C25H25ClN4O3, CAS 941977-52-2
2-(2-(4-Butoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl)-N-(4-chlorobenzyl)acetamide
CAS 941977-52-2C25H25ClN4O3
2-(2-(4-Butoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl)-N-(3-methoxybenzyl)acetamide chemical structure, C26H28N4O4, CAS 941887-00-9
2-(2-(4-Butoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl)-N-(3-methoxybenzyl)acetamide
CAS 941887-00-9C26H28N4O4
N-(4-Chlorobenzyl)-2-(4-oxo-2-phenylpyrazolo[1,5-a]pyrazin-5(4H)-yl)acetamide chemical structure, C21H17ClN4O2, CAS 941963-25-3
N-(4-Chlorobenzyl)-2-(4-oxo-2-phenylpyrazolo[1,5-a]pyrazin-5(4H)-yl)acetamide
CAS 941963-25-3C21H17ClN4O2
N-(2-Chlorobenzyl)-2-(4-oxo-2-phenylpyrazolo[1,5-a]pyrazin-5(4H)-yl)acetamide chemical structure, C21H17ClN4O2, CAS 941963-27-5
N-(2-Chlorobenzyl)-2-(4-oxo-2-phenylpyrazolo[1,5-a]pyrazin-5(4H)-yl)acetamide
CAS 941963-27-5C21H17ClN4O2
N-(2-Methoxybenzyl)-2-(4-oxo-2-phenylpyrazolo[1,5-a]pyrazin-5(4H)-yl)acetamide chemical structure, C22H20N4O3, CAS 941963-29-7
N-(2-Methoxybenzyl)-2-(4-oxo-2-phenylpyrazolo[1,5-a]pyrazin-5(4H)-yl)acetamide
CAS 941963-29-7C22H20N4O3
N-(4-Chlorobenzyl)-2-[2-(4-methylphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]acetamide chemical structure, C22H19ClN4O2, CAS 941963-87-7
N-(4-Chlorobenzyl)-2-[2-(4-methylphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]acetamide
CAS 941963-87-7C22H19ClN4O2
N-(4-Methoxybenzyl)-2-[2-(4-methylphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]acetamide chemical structure, C23H22N4O3, CAS 941921-17-1
N-(4-Methoxybenzyl)-2-[2-(4-methylphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]acetamide
CAS 941921-17-1C23H22N4O3
N-(3-Methoxybenzyl)-2-[2-(4-methylphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]acetamide chemical structure, C23H22N4O3, CAS 941963-90-2
N-(3-Methoxybenzyl)-2-[2-(4-methylphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]acetamide
CAS 941963-90-2C23H22N4O3
N-(2-Chlorobenzyl)-2-(4-oxo-2-(p-tolyl)pyrazolo[1,5-a]pyrazin-5(4H)-yl)acetamide chemical structure, C22H19ClN4O2, CAS 941921-19-3
N-(2-Chlorobenzyl)-2-(4-oxo-2-(p-tolyl)pyrazolo[1,5-a]pyrazin-5(4H)-yl)acetamide
CAS 941921-19-3C22H19ClN4O2
N-(2-Methoxybenzyl)-2-[2-(4-methylphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]acetamide chemical structure, C23H22N4O3, CAS 941921-22-8
N-(2-Methoxybenzyl)-2-[2-(4-methylphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]acetamide
CAS 941921-22-8C23H22N4O3
N-(3,4-Dimethoxybenzyl)-2-[2-(4-methylphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]acetamide chemical structure, C24H24N4O4, CAS 941963-96-8
N-(3,4-Dimethoxybenzyl)-2-[2-(4-methylphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]acetamide
CAS 941963-96-8C24H24N4O4