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Murcko scaffold

Ring system with 4 rings and 29 atoms

62 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
29
Chemicals
62
With full pages
9
Scaffold SMILES

O=C(COC(=O)c1ccc2c(c1)C(=O)N(c1ccccc1)C2=O)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(COC(=O)c1ccc2c(c1)C(=O)N(c1ccccc1)C2=O)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 62 chemicals

2-Oxo-2-phenylethyl 2-(2-methoxyphenyl)-1,3-dioxo-5-isoindolinecarboxylate chemical structure, C24H17NO6, CAS 298212-80-3
2-Oxo-2-phenylethyl 2-(2-methoxyphenyl)-1,3-dioxo-5-isoindolinecarboxylate
CAS 298212-80-3C24H17NO6
2-Oxo-2-phenylethyl 2-(4-methoxyphenyl)-1,3-dioxo-5-isoindolinecarboxylate chemical structure, C24H17NO6, CAS 313552-10-2
2-Oxo-2-phenylethyl 2-(4-methoxyphenyl)-1,3-dioxo-5-isoindolinecarboxylate
CAS 313552-10-2C24H17NO6
2-(4-Bromophenyl)-2-oxoethyl 2-(4-methoxyphenyl)-1,3-dioxo-5-isoindolinecarboxylate chemical structure, C24H16BrNO6, CAS 331269-37-5
2-(4-Bromophenyl)-2-oxoethyl 2-(4-methoxyphenyl)-1,3-dioxo-5-isoindolinecarboxylate
CAS 331269-37-5C24H16BrNO6
2-(4-Bromophenyl)-2-oxoethyl 2-(2-methylphenyl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylate chemical structure, C24H16BrNO5, CAS 331269-39-7
2-(4-Bromophenyl)-2-oxoethyl 2-(2-methylphenyl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylate
CAS 331269-39-7C24H16BrNO5
2-(4-Bromophenyl)-2-oxoethyl 2-(2,5-dimethylphenyl)-1,3-dioxo-5-isoindolinecarboxylate chemical structure, C25H18BrNO5, CAS 331269-80-8
2-(4-Bromophenyl)-2-oxoethyl 2-(2,5-dimethylphenyl)-1,3-dioxo-5-isoindolinecarboxylate
CAS 331269-80-8C25H18BrNO5
2-(4-Bromophenyl)-2-oxoethyl 2-[4-(acetylamino)phenyl]-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylate chemical structure, C25H17BrN2O6, CAS 331269-82-0
2-(4-Bromophenyl)-2-oxoethyl 2-[4-(acetylamino)phenyl]-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylate
CAS 331269-82-0C25H17BrN2O6
2-Oxo-2-phenylethyl 2-(2,4-dimethylphenyl)-1,3-dioxo-5-isoindolinecarboxylate chemical structure, C25H19NO5, CAS 351997-86-9
2-Oxo-2-phenylethyl 2-(2,4-dimethylphenyl)-1,3-dioxo-5-isoindolinecarboxylate
CAS 351997-86-9C25H19NO5
2-Oxo-2-phenylethyl 2-(4-iodo-2-methylphenyl)-1,3-dioxo-5-isoindolinecarboxylate chemical structure, C24H16INO5, CAS 312916-21-5
2-Oxo-2-phenylethyl 2-(4-iodo-2-methylphenyl)-1,3-dioxo-5-isoindolinecarboxylate
CAS 312916-21-5C24H16INO5
2-(4-Bromophenyl)-2-oxoethyl 2-(4-acetylphenyl)-1,3-dioxo-5-isoindolinecarboxylate chemical structure, C25H16BrNO6, CAS 331269-60-4
2-(4-Bromophenyl)-2-oxoethyl 2-(4-acetylphenyl)-1,3-dioxo-5-isoindolinecarboxylate
CAS 331269-60-4C25H16BrNO6
2-(4-Bromophenyl)-2-oxoethyl 2-(4-methylphenyl)-1,3-dioxoisoindoline-5-carboxylate chemical structure, C24H16BrNO5, CAS 331269-42-2
2-(4-Bromophenyl)-2-oxoethyl 2-(4-methylphenyl)-1,3-dioxoisoindoline-5-carboxylate
CAS 331269-42-2C24H16BrNO5
Phenacyl 2-(3-acetylphenyl)-1,3-dioxoisoindole-5-carboxylate chemical structure, C25H17NO6, CAS 298212-79-0
Phenacyl 2-(3-acetylphenyl)-1,3-dioxoisoindole-5-carboxylate
CAS 298212-79-0C25H17NO6
2-(4-Ethylphenyl)-2-oxoethyl 2-(2-methoxyphenyl)-1,3-dioxo-5-isoindolinecarboxylate chemical structure, C26H21NO6, CAS 524043-24-1
2-(4-Ethylphenyl)-2-oxoethyl 2-(2-methoxyphenyl)-1,3-dioxo-5-isoindolinecarboxylate
CAS 524043-24-1C26H21NO6
2-(4-Bromophenyl)-2-oxoethyl 1,3-dioxo-2-phenylisoindoline-5-carboxylate chemical structure, C23H14BrNO5, CAS 351444-37-6
2-(4-Bromophenyl)-2-oxoethyl 1,3-dioxo-2-phenylisoindoline-5-carboxylate
CAS 351444-37-6C23H14BrNO5
2-(3-Nitrophenyl)-2-oxoethyl 2-(2-chlorophenyl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylate chemical structure, C23H13ClN2O7, CAS 352005-10-8
2-(3-Nitrophenyl)-2-oxoethyl 2-(2-chlorophenyl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylate
CAS 352005-10-8C23H13ClN2O7
2-(3-Nitrophenyl)-2-oxoethyl 2-(2-methoxyphenyl)-1,3-dioxoisoindoline-5-carboxylate chemical structure, C24H16N2O8, CAS 352005-43-7
2-(3-Nitrophenyl)-2-oxoethyl 2-(2-methoxyphenyl)-1,3-dioxoisoindoline-5-carboxylate
CAS 352005-43-7C24H16N2O8
2-(3-Nitrophenyl)-2-oxoethyl 2-(2-hydroxyphenyl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylate chemical structure, C23H14N2O8, CAS 352005-46-0
2-(3-Nitrophenyl)-2-oxoethyl 2-(2-hydroxyphenyl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylate
CAS 352005-46-0C23H14N2O8
2-(3-Nitrophenyl)-2-oxoethyl 2-(3-chlorophenyl)-1,3-dioxoisoindoline-5-carboxylate chemical structure, C23H13ClN2O7, CAS 352005-15-3
2-(3-Nitrophenyl)-2-oxoethyl 2-(3-chlorophenyl)-1,3-dioxoisoindoline-5-carboxylate
CAS 352005-15-3C23H13ClN2O7
2-{3-Nitrophenyl}-2-oxoethyl 2-(3-hydroxyphenyl)-1,3-dioxoisoindoline-5-carboxylate chemical structure, C23H14N2O8, CAS 352005-26-6
2-{3-Nitrophenyl}-2-oxoethyl 2-(3-hydroxyphenyl)-1,3-dioxoisoindoline-5-carboxylate
CAS 352005-26-6C23H14N2O8
[2-(3-Nitrophenyl)-2-oxoethyl] 2-(2-methylphenyl)-1,3-dioxoisoindole-5-carboxylate chemical structure, C24H16N2O7, CAS 352005-36-8
[2-(3-Nitrophenyl)-2-oxoethyl] 2-(2-methylphenyl)-1,3-dioxoisoindole-5-carboxylate
CAS 352005-36-8C24H16N2O7
2-(4-Nitrophenyl)-2-oxoethyl 2-(3-chloro-4-methylphenyl)-1,3-dioxoisoindoline-5-carboxylate chemical structure, C24H15ClN2O7, CAS 352218-96-3
2-(4-Nitrophenyl)-2-oxoethyl 2-(3-chloro-4-methylphenyl)-1,3-dioxoisoindoline-5-carboxylate
CAS 352218-96-3C24H15ClN2O7
2-(4-Nitrophenyl)-2-oxoethyl 2-(3-acetylphenyl)-1,3-dioxoisoindoline-5-carboxylate chemical structure, C25H16N2O8, CAS 352219-08-0
2-(4-Nitrophenyl)-2-oxoethyl 2-(3-acetylphenyl)-1,3-dioxoisoindoline-5-carboxylate
CAS 352219-08-0C25H16N2O8
2-(4-Methylphenyl)-2-oxoethyl 2-(3-chloro-4-methylphenyl)-1,3-dioxo-5-isoindolinecarboxylate chemical structure, C25H18ClNO5, CAS 351896-27-0
2-(4-Methylphenyl)-2-oxoethyl 2-(3-chloro-4-methylphenyl)-1,3-dioxo-5-isoindolinecarboxylate
CAS 351896-27-0C25H18ClNO5
2-(4-Methylphenyl)-2-oxoethyl 2-(3-methylphenyl)-1,3-dioxo-5-isoindolinecarboxylate chemical structure, C25H19NO5, CAS 351896-35-0
2-(4-Methylphenyl)-2-oxoethyl 2-(3-methylphenyl)-1,3-dioxo-5-isoindolinecarboxylate
CAS 351896-35-0C25H19NO5
2-(4-Methoxyphenyl)-2-oxoethyl 2-(2,5-dichlorophenyl)-1,3-dioxo-5-isoindolinecarboxylate chemical structure, C24H15Cl2NO6, CAS 351496-74-7
2-(4-Methoxyphenyl)-2-oxoethyl 2-(2,5-dichlorophenyl)-1,3-dioxo-5-isoindolinecarboxylate
CAS 351496-74-7C24H15Cl2NO6