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Murcko scaffold

1-Prolylpiperazine scaffold

31 chemicals on CompoundList share this ring system.

Rings: 2
Scaffold atoms: 13
Chemicals: 31
With full pages: 3

Scaffold SMILES

O=C(C1CCCN1)N1CCNCC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold Open the 1-Prolylpiperazine page

Murcko scaffold O=C(C1CCCN1)N1CCNCC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 31 of 31 chemicals

(4-Methyl-piperazin-1-yl)-(S)-pyrrolidin-2-yl-methanone chemical structure, C10H19N3O, CAS 100158-68-7

(4-Methyl-piperazin-1-yl)-(S)-pyrrolidin-2-yl-methanone

CAS 100158-68-7C₁₀H₁₉N₃O

1-Methyl-4-(pyrrolidine-2-carbonyl)piperazine chemical structure, C10H19N3O, CAS 116818-82-7

1-Methyl-4-(pyrrolidine-2-carbonyl)piperazine

CAS 116818-82-7C₁₀H₁₉N₃O

1-(1-Methylpyrrolidine-2-carbonyl)piperazine chemical structure, C10H19N3O, CAS 1248383-26-7

1-(1-Methylpyrrolidine-2-carbonyl)piperazine

CAS 1248383-26-7C₁₀H₁₉N₃O

1-[(2S)-Pyrrolidine-2-carbonyl]piperazine chemical structure, C9H17N3O, CAS 1308446-12-9

1-[(2S)-Pyrrolidine-2-carbonyl]piperazine

CAS 1308446-12-9C₉H₁₇N₃O

1-Prolylpiperazine chemical structure, C9H17N3O, CAS 1228686-81-4

1-Prolylpiperazine

CAS 1228686-81-4C₉H₁₇N₃O

(S)-1-(Methylsulfonyl)-4-prolylpiperazine chemical structure, C10H19N3O3S

(S)-1-(Methylsulfonyl)-4-prolylpiperazine

C₁₀H₁₉N₃O₃S

tert-Butyl 4-(pyrrolidine-2-carbonyl)piperazine-1-carboxylate chemical structure, C14H25N3O3, CAS 1219201-40-7

tert-Butyl 4-(pyrrolidine-2-carbonyl)piperazine-1-carboxylate

CAS 1219201-40-7C₁₄H₂₅N₃O₃

tert-Butyl (2S)-2-(piperazine-1-carbonyl)pyrrolidine-1-carboxylate chemical structure, C14H25N3O3, CAS 1305710-99-9

tert-Butyl (2S)-2-(piperazine-1-carbonyl)pyrrolidine-1-carboxylate

CAS 1305710-99-9C₁₄H₂₅N₃O₃

tert-Butyl 4-((2S)-pyrrolidine-2-carbonyl)piperazine-1-carboxylate chemical structure, C14H25N3O3, CAS 1308650-55-6

tert-Butyl 4-((2S)-pyrrolidine-2-carbonyl)piperazine-1-carboxylate

CAS 1308650-55-6C₁₄H₂₅N₃O₃

tert-Butyl 4-[(2R)-pyrrolidine-2-carbonyl]piperazine-1-carboxylate chemical structure, C14H25N3O3, CAS 2173637-52-8

tert-Butyl 4-[(2R)-pyrrolidine-2-carbonyl]piperazine-1-carboxylate

CAS 2173637-52-8C₁₄H₂₅N₃O₃

(4-Methyl-1-piperazinyl)(2-pyrrolidinyl)methanone hydrochloride chemical structure, C10H20ClN3O, CAS 1236260-93-7

(4-Methyl-1-piperazinyl)(2-pyrrolidinyl)methanone hydrochloride

CAS 1236260-93-7C₁₀H₂₀ClN₃O

[4-(2-Hydroxyethyl)-1-piperazinyl](2-pyrrolidinyl) methanone hydrochloride chemical structure, C11H22ClN3O2, CAS 1236260-66-4

[4-(2-Hydroxyethyl)-1-piperazinyl](2-pyrrolidinyl) methanone hydrochloride

CAS 1236260-66-4C₁₁H₂₂ClN₃O₂

tert-Butyl (2S)-2-[(piperazin-1-yl)carbonyl]pyrrolidine-1-carboxylate chemical structure, C14H25N3O3, CAS 939979-76-7

tert-Butyl (2S)-2-[(piperazin-1-yl)carbonyl]pyrrolidine-1-carboxylate

CAS 939979-76-7C₁₄H₂₅N₃O₃

1-[(2S)-1-Methylpyrrolidine-2-carbonyl]piperazine chemical structure, C10H19N3O, CAS 1215385-64-0

1-[(2S)-1-Methylpyrrolidine-2-carbonyl]piperazine

CAS 1215385-64-0C₁₀H₁₉N₃O

1-(2-Methylpropyl)-4-(pyrrolidine-2-carbonyl)piperazine chemical structure, C13H25N3O, CAS 1266726-12-8

1-(2-Methylpropyl)-4-(pyrrolidine-2-carbonyl)piperazine

CAS 1266726-12-8C₁₃H₂₅N₃O

1-[4-(Pyrrolidine-2-carbonyl)piperazin-1-yl]ethan-1-one chemical structure, C11H19N3O2, CAS 1251233-36-9

1-[4-(Pyrrolidine-2-carbonyl)piperazin-1-yl]ethan-1-one

CAS 1251233-36-9C₁₁H₁₉N₃O₂

1-(Methylsulfonyl)-4-prolylpiperazine chemical structure, C10H19N3O3S, CAS 1281754-80-0

1-(Methylsulfonyl)-4-prolylpiperazine

CAS 1281754-80-0C₁₀H₁₉N₃O₃S

(2S)-1-(tert-Butoxycarbonyl)-2-(4-methylpiperazin-1-ylcarbonyl)pyrrolidine chemical structure, C15H27N3O3, CAS 537040-25-8

(2S)-1-(tert-Butoxycarbonyl)-2-(4-methylpiperazin-1-ylcarbonyl)pyrrolidine

CAS 537040-25-8C₁₅H₂₇N₃O₃

1-[(2R)-Pyrrolidine-2-carbonyl]piperazine chemical structure, C9H17N3O, CAS 1604300-97-1

1-[(2R)-Pyrrolidine-2-carbonyl]piperazine

CAS 1604300-97-1C₉H₁₇N₃O

1-(1-Methylpyrrolidine-2-carbonyl)piperazine dihydrochloride chemical structure, C10H21Cl2N3O, CAS 1394040-06-2

1-(1-Methylpyrrolidine-2-carbonyl)piperazine dihydrochloride

CAS 1394040-06-2C₁₀H₂₁Cl₂N₃O

2-(Piperazine-1-carbonyl)pyrrolidine-1-carbaldehyde chemical structure, C10H17N3O2, CAS 1352311-19-3

2-(Piperazine-1-carbonyl)pyrrolidine-1-carbaldehyde

CAS 1352311-19-3C₁₀H₁₇N₃O₂

1-(2-Methoxyethyl)-4-prolylpiperazine chemical structure, C12H23N3O2, CAS 1506251-22-4

1-(2-Methoxyethyl)-4-prolylpiperazine

CAS 1506251-22-4C₁₂H₂₃N₃O₂

(2S,4S)-1-Boc-4-azido-2-[(4-methylpiperazin-1-yl)carbonyl]pyrrolidine chemical structure, C15H26N6O3, CAS 1226771-89-6

(2S,4S)-1-Boc-4-azido-2-[(4-methylpiperazin-1-yl)carbonyl]pyrrolidine

CAS 1226771-89-6C₁₅H₂₆N₆O₃

1-(Methylsulfonyl)-4-prolylpiperazine hydrochloride chemical structure, C10H20ClN3O3S, CAS 1582100-49-9

1-(Methylsulfonyl)-4-prolylpiperazine hydrochloride

CAS 1582100-49-9C₁₀H₂₀ClN₃O₃S