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Murcko scaffold

Ring system with 3 rings and 21 atoms

15 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 21
Chemicals: 15
With full pages: 7

Scaffold SMILES

O=C(NN=Cc1cccs1)c1cc(-c2ccccc2)n[nH]1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(NN=Cc1cccs1)c1cc(-c2ccccc2)n[nH]1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 15 of 15 chemicals

5-(4-Fluorophenyl)-1H-pyrazole-3-carboxylic acid 2-[1-(2-thienyl)ethylidene]hydrazide chemical structure, C16H13FN4OS, CAS 488098-46-0

5-(4-Fluorophenyl)-1H-pyrazole-3-carboxylic acid 2-[1-(2-thienyl)ethylidene]hydrazide

CAS 488098-46-0C₁₆H₁₃FN₄OS

5-(3,4-Dimethylphenyl)-1H-pyrazole-3-carboxylic acid 2-[1-(2-thienyl)ethylidene]hydrazide chemical structure, C18H18N4OS, CAS 1038397-91-9

5-(3,4-Dimethylphenyl)-1H-pyrazole-3-carboxylic acid 2-[1-(2-thienyl)ethylidene]hydrazide

CAS 1038397-91-9C₁₈H₁₈N₄OS

3-(3-Ethoxyphenyl)-N'-[(E)-thiophen-2-ylmethylidene]-1H-pyrazole-5-carbohydrazide chemical structure, C17H16N4O2S, CAS 303204-19-5

3-(3-Ethoxyphenyl)-N'-[(E)-thiophen-2-ylmethylidene]-1H-pyrazole-5-carbohydrazide

CAS 303204-19-5C₁₇H₁₆N₄O₂S

3-(4-Methoxyphenyl)-N'-[(1E)-1-(thiophen-2-yl)ethylidene]-1H-pyrazole-5-carbohydrazide chemical structure, C17H16N4O2S, CAS 307325-23-1

3-(4-Methoxyphenyl)-N'-[(1E)-1-(thiophen-2-yl)ethylidene]-1H-pyrazole-5-carbohydrazide

CAS 307325-23-1C₁₇H₁₆N₄O₂S

3-(3-Nitrophenyl)-N'-(2-thienylmethylene)-1H-pyrazole-5-carbohydrazide chemical structure, C15H11N5O3S, CAS 303106-87-8

3-(3-Nitrophenyl)-N'-(2-thienylmethylene)-1H-pyrazole-5-carbohydrazide

CAS 303106-87-8C₁₅H₁₁N₅O₃S

(E)-3-(4-Butoxyphenyl)-N'-(thiophen-2-ylmethylene)-1H-pyrazole-5-carbohydrazide chemical structure, C19H20N4O2S, CAS 634899-35-7

(E)-3-(4-Butoxyphenyl)-N'-(thiophen-2-ylmethylene)-1H-pyrazole-5-carbohydrazide

CAS 634899-35-7C₁₉H₂₀N₄O₂S

3-(2-Ethoxyphenyl)-N'-(2-thienylmethylene)-1H-pyrazole-5-carbohydrazide chemical structure, C17H16N4O2S, CAS 302917-88-0

3-(2-Ethoxyphenyl)-N'-(2-thienylmethylene)-1H-pyrazole-5-carbohydrazide

CAS 302917-88-0C₁₇H₁₆N₄O₂S

3-(4-Isobutylphenyl)-N'-(2-thienylmethylene)-1H-pyrazole-5-carbohydrazide chemical structure, C19H20N4OS, CAS 303107-07-5

3-(4-Isobutylphenyl)-N'-(2-thienylmethylene)-1H-pyrazole-5-carbohydrazide

CAS 303107-07-5C₁₉H₂₀N₄OS

(E)-3-(4-Ethoxy-3-methoxyphenyl)-N'-(thiophen-2-ylmethylene)-1H-pyrazole-5-carbohydrazide chemical structure, C18H18N4O3S, CAS 634894-99-8

(E)-3-(4-Ethoxy-3-methoxyphenyl)-N'-(thiophen-2-ylmethylene)-1H-pyrazole-5-carbohydrazide

CAS 634894-99-8C₁₈H₁₈N₄O₃S

(E)-3-(4-Isopropoxyphenyl)-N'-(thiophen-2-ylmethylene)-1H-pyrazole-5-carbohydrazide chemical structure, C18H18N4O2S, CAS 634894-77-2

(E)-3-(4-Isopropoxyphenyl)-N'-(thiophen-2-ylmethylene)-1H-pyrazole-5-carbohydrazide

CAS 634894-77-2C₁₈H₁₈N₄O₂S

3-(4-Methoxyphenyl)-4-ME-N'-(2-thienylmethylene)-1H-pyrazole-5-carbohydrazide chemical structure, C17H16N4O2S, CAS 303104-06-5

3-(4-Methoxyphenyl)-4-ME-N'-(2-thienylmethylene)-1H-pyrazole-5-carbohydrazide

CAS 303104-06-5C₁₇H₁₆N₄O₂S

(E)-3-(4-Isopropoxy-3-methoxyphenyl)-N'-(thiophen-2-ylmethylene)-1H-pyrazole-5-carbohydrazide chemical structure, C19H20N4O3S, CAS 1285537-66-7

(E)-3-(4-Isopropoxy-3-methoxyphenyl)-N'-(thiophen-2-ylmethylene)-1H-pyrazole-5-carbohydrazide

CAS 1285537-66-7C₁₉H₂₀N₄O₃S

3-(3-Ethoxyphenyl)-N'-(1-(2-thienyl)ethylidene)-1H-pyrazole-5-carbohydrazide chemical structure, C18H18N4O2S, CAS 303107-66-6

3-(3-Ethoxyphenyl)-N'-(1-(2-thienyl)ethylidene)-1H-pyrazole-5-carbohydrazide

CAS 303107-66-6C₁₈H₁₈N₄O₂S

3-(4-(Octyloxy)phenyl)-N'-(2-thienylmethylene)-1H-pyrazole-5-carbohydrazide chemical structure, C23H28N4O2S, CAS 303104-81-6

3-(4-(Octyloxy)phenyl)-N'-(2-thienylmethylene)-1H-pyrazole-5-carbohydrazide

CAS 303104-81-6C₂₃H₂₈N₄O₂S

3-(2-Ethoxyphenyl)-N'-(1-(2-thienyl)ethylidene)-1H-pyrazole-5-carbohydrazide chemical structure, C18H18N4O2S, CAS 303104-09-8

3-(2-Ethoxyphenyl)-N'-(1-(2-thienyl)ethylidene)-1H-pyrazole-5-carbohydrazide

CAS 303104-09-8C₁₈H₁₈N₄O₂S