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Murcko scaffold

2-((5-(Pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(thiazol-2-yl)acetamide scaffold

13 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
21
Chemicals
13
With full pages
3
Scaffold SMILES

O=C(CSc1nnc(-c2ccncc2)[nH]1)Nc1nccs1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2-((5-(Pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(thiazol-2-yl)acetamide page
Murcko scaffold O=C(CSc1nnc(-c2ccncc2)[nH]1)Nc1nccs1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 13 of 13 chemicals

2-[(4-Methyl-5-pyridin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-(5-methyl-1,3-thiazol-2-yl)acetamide chemical structure, C14H14N6OS2, CAS 482636-96-4
2-[(4-Methyl-5-pyridin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-(5-methyl-1,3-thiazol-2-yl)acetamide
CAS 482636-96-4C14H14N6OS2
2-{[4-Ethyl-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio}-N-1,3-thiazol-2-ylacetamide chemical structure, C14H14N6OS2, CAS 701225-92-5
2-{[4-Ethyl-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio}-N-1,3-thiazol-2-ylacetamide
CAS 701225-92-5C14H14N6OS2
2-[(4-Ethyl-5-pyridin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-(4-methyl-1,3-thiazol-2-yl)acetamide chemical structure, C15H16N6OS2, CAS 557063-92-0
2-[(4-Ethyl-5-pyridin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-(4-methyl-1,3-thiazol-2-yl)acetamide
CAS 557063-92-0C15H16N6OS2
2-((5-(Pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(thiazol-2-yl)acetamide chemical structure, C12H10N6OS2, CAS 833434-07-4
2-((5-(Pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(thiazol-2-yl)acetamide
CAS 833434-07-4C12H10N6OS2
2-[(4-Prop-2-enyl-5-pyridin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-(1,3-thiazol-2-yl)acetamide chemical structure, C15H14N6OS2, CAS 497176-17-7
2-[(4-Prop-2-enyl-5-pyridin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-(1,3-thiazol-2-yl)acetamide
CAS 497176-17-7C15H14N6OS2
2-[4-(3-Dimethylamino-propyl)-5-pyridin-4-yl-4H-[1,2,4]triazol-3-ylsulfanyl]-N-thiazol-2-yl-acetamide chemical structure, C17H21N7OS2, CAS 485338-92-9
2-[4-(3-Dimethylamino-propyl)-5-pyridin-4-yl-4H-[1,2,4]triazol-3-ylsulfanyl]-N-thiazol-2-yl-acetamide
CAS 485338-92-9C17H21N7OS2
2-{[4-Amino-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(1,3-thiazol-2-yl)acetamide chemical structure, C12H11N7OS2, CAS 442670-47-5
2-{[4-Amino-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(1,3-thiazol-2-yl)acetamide
CAS 442670-47-5C12H11N7OS2
N-(4,5-Dimethyl-1,3-thiazol-2-yl)-2-[(4-ethyl-5-pyridin-4-yl-1,2,4-triazol-3-yl)sulfanyl]propanamide chemical structure, C17H20N6OS2, CAS 892671-55-5
N-(4,5-Dimethyl-1,3-thiazol-2-yl)-2-[(4-ethyl-5-pyridin-4-yl-1,2,4-triazol-3-yl)sulfanyl]propanamide
CAS 892671-55-5C17H20N6OS2
2-[(4-Prop-2-enyl-5-pyridin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-(1,3-thiazol-2-yl)propanamide chemical structure, C16H16N6OS2, CAS 892686-46-3
2-[(4-Prop-2-enyl-5-pyridin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-(1,3-thiazol-2-yl)propanamide
CAS 892686-46-3C16H16N6OS2
N-(4,5-Dimethyl-1,3-thiazol-2-yl)-2-[(4-methyl-5-pyridin-4-yl-1,2,4-triazol-3-yl)sulfanyl]propanamide chemical structure, C16H18N6OS2, CAS 879061-94-6
N-(4,5-Dimethyl-1,3-thiazol-2-yl)-2-[(4-methyl-5-pyridin-4-yl-1,2,4-triazol-3-yl)sulfanyl]propanamide
CAS 879061-94-6C16H18N6OS2
2-[(4-Methyl-5-pyridin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-(1,3-thiazol-2-yl)propanamide chemical structure, C14H14N6OS2, CAS 879061-83-3
2-[(4-Methyl-5-pyridin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-(1,3-thiazol-2-yl)propanamide
CAS 879061-83-3C14H14N6OS2
N-(4-Methyl-1,3-thiazol-2-yl)-2-{[4-(prop-2-en-1-yl)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}propanamide chemical structure, C17H18N6OS2, CAS 906212-61-1
N-(4-Methyl-1,3-thiazol-2-yl)-2-{[4-(prop-2-en-1-yl)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}propanamide
CAS 906212-61-1C17H18N6OS2
N-(4,5-Dimethyl-1,3-thiazol-2-yl)-2-{[4-(prop-2-en-1-yl)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}propanamide chemical structure, C18H20N6OS2, CAS 948824-42-8
N-(4,5-Dimethyl-1,3-thiazol-2-yl)-2-{[4-(prop-2-en-1-yl)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}propanamide
CAS 948824-42-8C18H20N6OS2