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Murcko scaffold

Thiophene-2-carboxylic acid, morpholide scaffold

23 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
13
Chemicals
23
With full pages
4
Scaffold SMILES

O=C(c1cccs1)N1CCOCC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the Thiophene-2-carboxylic acid, morpholide page
Murcko scaffold O=C(c1cccs1)N1CCOCC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 23 of 23 chemicals

Morpholine, 4-((5-nitro-2-thienyl)carbonyl)- chemical structure, C9H10N2O4S, CAS 31330-60-6
Morpholine, 4-((5-nitro-2-thienyl)carbonyl)-
CAS 31330-60-6C9H10N2O4S
Thiophene-2-carboxylic acid, morpholide chemical structure, C9H11NO2S, CAS 31330-61-7
Thiophene-2-carboxylic acid, morpholide
CAS 31330-61-7C9H11NO2S
Ethyl 2-amino-4-methyl-5-(morpholine-4-carbonyl)thiophene-3-carboxylate chemical structure, C13H18N2O4S, CAS 314046-67-8
Ethyl 2-amino-4-methyl-5-(morpholine-4-carbonyl)thiophene-3-carboxylate
CAS 314046-67-8C13H18N2O4S
Methyl 2-amino-4-methyl-5-(morpholin-4-ylcarbonyl)thiophene-3-carboxylate chemical structure, C12H16N2O4S, CAS 832107-65-0
Methyl 2-amino-4-methyl-5-(morpholin-4-ylcarbonyl)thiophene-3-carboxylate
CAS 832107-65-0C12H16N2O4S
4-(5-Chlorothiophene-2-carbonyl)morpholine chemical structure, C9H10ClNO2S, CAS 774574-91-3
4-(5-Chlorothiophene-2-carbonyl)morpholine
CAS 774574-91-3C9H10ClNO2S
(5-Bromothiophen-2-yl)(morpholin-4-yl)methanone chemical structure, C9H10BrNO2S, CAS 325743-60-0
(5-Bromothiophen-2-yl)(morpholin-4-yl)methanone
CAS 325743-60-0C9H10BrNO2S
(4-Bromothiophen-2-yl)(morpholin-4-yl)methanone chemical structure, C9H10BrNO2S, CAS 587853-53-0
(4-Bromothiophen-2-yl)(morpholin-4-yl)methanone
CAS 587853-53-0C9H10BrNO2S
(4-Bromo-5-ethylthiophen-2-yl)-morpholin-4-ylmethanone chemical structure, C11H14BrNO2S, CAS 588676-52-2
(4-Bromo-5-ethylthiophen-2-yl)-morpholin-4-ylmethanone
CAS 588676-52-2C11H14BrNO2S
5-(Morpholine-4-carbonyl)thiophene-2-carboxylic acid chemical structure, C10H11NO4S, CAS 921596-88-5
5-(Morpholine-4-carbonyl)thiophene-2-carboxylic acid
CAS 921596-88-5C10H11NO4S
(5-Chlorothiophen-2-yl)(2,6-dimethylmorpholin-4-yl)methanone chemical structure, C11H14ClNO2S, CAS 1015850-81-3
(5-Chlorothiophen-2-yl)(2,6-dimethylmorpholin-4-yl)methanone
CAS 1015850-81-3C11H14ClNO2S
5-(Morpholine-4-carbonyl)thiophene-2-carbohydrazide chemical structure, C10H13N3O3S, CAS 921596-40-9
5-(Morpholine-4-carbonyl)thiophene-2-carbohydrazide
CAS 921596-40-9C10H13N3O3S
4-(3-Bromothiophene-2-carbonyl)morpholine-3-carboxylic acid chemical structure, C10H10BrNO4S, CAS 1498716-91-8
4-(3-Bromothiophene-2-carbonyl)morpholine-3-carboxylic acid
CAS 1498716-91-8C10H10BrNO4S
4-(5-Methylthiophene-2-carbonyl)morpholine-3-carboxylic acid chemical structure, C11H13NO4S, CAS 1468506-71-9
4-(5-Methylthiophene-2-carbonyl)morpholine-3-carboxylic acid
CAS 1468506-71-9C11H13NO4S
(5-Bromo-4-methylthiophen-2-yl)(morpholin-4-yl)methanone chemical structure, C10H12BrNO2S, CAS 860344-44-1
(5-Bromo-4-methylthiophen-2-yl)(morpholin-4-yl)methanone
CAS 860344-44-1C10H12BrNO2S
Methyl 5-(morpholine-4-carbonyl)thiophene-2-carboxylate chemical structure, C11H13NO4S, CAS 921596-41-0
Methyl 5-(morpholine-4-carbonyl)thiophene-2-carboxylate
CAS 921596-41-0C11H13NO4S
4-(3-Methoxythiophene-2-carbonyl)morpholine-3-carbonitrile chemical structure, C11H12N2O3S, CAS 1436069-17-8
4-(3-Methoxythiophene-2-carbonyl)morpholine-3-carbonitrile
CAS 1436069-17-8C11H12N2O3S
(5-Chlorothiophen-2-yl)(3,3-dimethylmorpholino)methanone chemical structure, C11H14ClNO2S, CAS 2124945-90-8
(5-Chlorothiophen-2-yl)(3,3-dimethylmorpholino)methanone
CAS 2124945-90-8C11H14ClNO2S
B-[5-(4-Morpholinylcarbonyl)-2-thienyl]boronic acid chemical structure, C9H12BNO4S, CAS 1383532-13-5
B-[5-(4-Morpholinylcarbonyl)-2-thienyl]boronic acid
CAS 1383532-13-5C9H12BNO4S
4-[5-(Azidomethyl)thiophene-2-carbonyl]morpholine chemical structure, C10H12N4O2S, CAS 2324697-29-0
4-[5-(Azidomethyl)thiophene-2-carbonyl]morpholine
CAS 2324697-29-0C10H12N4O2S
4-[5-(Azidomethyl)thiophene-2-carbonyl]-2,6-dimethylmorpholine chemical structure, C12H16N4O2S, CAS 2325993-80-2
4-[5-(Azidomethyl)thiophene-2-carbonyl]-2,6-dimethylmorpholine
CAS 2325993-80-2C12H16N4O2S
(2R,6S)-4-[5-(Azidomethyl)thiophene-2-carbonyl]-2,6-dimethylmorpholine chemical structure, C12H16N4O2S, CAS 2326119-08-6
(2R,6S)-4-[5-(Azidomethyl)thiophene-2-carbonyl]-2,6-dimethylmorpholine
CAS 2326119-08-6C12H16N4O2S
4-(5-Methyl-4-nitrothiophene-2-carbonyl)morpholine-3-carbonitrile chemical structure, C11H11N3O4S, CAS 2128599-79-9
4-(5-Methyl-4-nitrothiophene-2-carbonyl)morpholine-3-carbonitrile
CAS 2128599-79-9C11H11N3O4S
[4-(Thiophene-2-carbonyl)morpholin-2-yl]methanesulfonyl fluoride chemical structure, C10H12FNO4S2, CAS 2249464-96-6
[4-(Thiophene-2-carbonyl)morpholin-2-yl]methanesulfonyl fluoride
CAS 2249464-96-6C10H12FNO4S2