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Murcko scaffold

Ring system with 2 rings and 21 atoms

22 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
21
Chemicals
22
With full pages
3
Scaffold SMILES

O=C(CSCC(=O)Nc1ccccc1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CSCC(=O)Nc1ccccc1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 22 of 22 chemicals

2-[2-(4-Ethylanilino)-2-oxoethyl]sulfanyl-N-phenylacetamide chemical structure, C18H20N2O2S, CAS 296274-33-4
2-[2-(4-Ethylanilino)-2-oxoethyl]sulfanyl-N-phenylacetamide
CAS 296274-33-4C18H20N2O2S
N-(2-Isopropoxy-phenyl)-2-phenylcarbamoylmethylsulfanyl-acetamide chemical structure, C19H22N2O3S, CAS 423731-36-6
N-(2-Isopropoxy-phenyl)-2-phenylcarbamoylmethylsulfanyl-acetamide
CAS 423731-36-6C19H22N2O3S
2-Phenylcarbamoylmethylsulfanyl-N-(3-trifluoromethyl-phenyl)-acetamide chemical structure, C17H15F3N2O2S, CAS 346465-99-4
2-Phenylcarbamoylmethylsulfanyl-N-(3-trifluoromethyl-phenyl)-acetamide
CAS 346465-99-4C17H15F3N2O2S
2-(2-Anilino-2-oxoethyl)sulfanyl-N-(2,4,6-trimethylphenyl)propanamide chemical structure, C20H24N2O2S, CAS 355810-27-4
2-(2-Anilino-2-oxoethyl)sulfanyl-N-(2,4,6-trimethylphenyl)propanamide
CAS 355810-27-4C20H24N2O2S
AG-205/05852034 chemical structure, C18H20N2O2S, CAS 5928-42-7
AG-205/05852034
CAS 5928-42-7C18H20N2O2S
2-[2-(3-Fluoro-2-methylanilino)-2-oxoethyl]sulfanyl-N-phenylacetamide chemical structure, C17H17FN2O2S, CAS 431931-49-6
2-[2-(3-Fluoro-2-methylanilino)-2-oxoethyl]sulfanyl-N-phenylacetamide
CAS 431931-49-6C17H17FN2O2S
2-[2-(5-Chloro-2-methylanilino)-2-oxoethyl]sulfanyl-N-phenylacetamide chemical structure, C17H17ClN2O2S, CAS 423731-32-2
2-[2-(5-Chloro-2-methylanilino)-2-oxoethyl]sulfanyl-N-phenylacetamide
CAS 423731-32-2C17H17ClN2O2S
Methyl 2-[({[2-(2-methoxyanilino)-2-oxoethyl]sulfanyl}acetyl)amino]benzoate chemical structure, C19H20N2O5S, CAS 385377-07-1
Methyl 2-[({[2-(2-methoxyanilino)-2-oxoethyl]sulfanyl}acetyl)amino]benzoate
CAS 385377-07-1C19H20N2O5S
2-[2-(4-Fluoroanilino)-2-oxoethyl]sulfanyl-N-phenylacetamide chemical structure, C16H15FN2O2S, CAS 296274-31-2
2-[2-(4-Fluoroanilino)-2-oxoethyl]sulfanyl-N-phenylacetamide
CAS 296274-31-2C16H15FN2O2S
2-[2-(4-Bromoanilino)-2-oxoethyl]sulfanyl-N-phenylacetamide chemical structure, C16H15BrN2O2S, CAS 431979-60-1
2-[2-(4-Bromoanilino)-2-oxoethyl]sulfanyl-N-phenylacetamide
CAS 431979-60-1C16H15BrN2O2S
2-[2-Oxo-2-[2-(trifluoromethyl)anilino]ethyl]sulfanyl-N-phenylacetamide chemical structure, C17H15F3N2O2S, CAS 433261-49-5
2-[2-Oxo-2-[2-(trifluoromethyl)anilino]ethyl]sulfanyl-N-phenylacetamide
CAS 433261-49-5C17H15F3N2O2S
2-{[2-(2,4-Dichloro-5-isopropoxyanilino)-2-oxoethyl]sulfanyl}-N-(4-methoxyphenyl)acetamide chemical structure, C20H22Cl2N2O4S, CAS 341964-58-7
2-{[2-(2,4-Dichloro-5-isopropoxyanilino)-2-oxoethyl]sulfanyl}-N-(4-methoxyphenyl)acetamide
CAS 341964-58-7C20H22Cl2N2O4S
2-{[2-(2,4-Dichloro-5-isopropoxyanilino)-2-oxoethyl]sulfanyl}-N-(2,4-difluorophenyl)acetamide chemical structure, C19H18Cl2F2N2O3S, CAS 341964-62-3
2-{[2-(2,4-Dichloro-5-isopropoxyanilino)-2-oxoethyl]sulfanyl}-N-(2,4-difluorophenyl)acetamide
CAS 341964-62-3C19H18Cl2F2N2O3S
2-{[2-(2,4-Dichloro-5-isopropoxyanilino)-2-oxoethyl]sulfanyl}-N-[3-(trifluoromethyl)phenyl]acetamide chemical structure, C20H19Cl2F3N2O3S, CAS 341964-74-7
2-{[2-(2,4-Dichloro-5-isopropoxyanilino)-2-oxoethyl]sulfanyl}-N-[3-(trifluoromethyl)phenyl]acetamide
CAS 341964-74-7C20H19Cl2F3N2O3S
2-{[2-(2,4-Dichloro-5-methoxyanilino)-2-oxoethyl]sulfanyl}-N-[3-(trifluoromethyl)phenyl]acetamide chemical structure, C18H15Cl2F3N2O3S, CAS 341965-12-6
2-{[2-(2,4-Dichloro-5-methoxyanilino)-2-oxoethyl]sulfanyl}-N-[3-(trifluoromethyl)phenyl]acetamide
CAS 341965-12-6C18H15Cl2F3N2O3S
2-[2-(3-Nitroanilino)-2-oxoethyl]sulfanyl-N-phenylacetamide chemical structure, C16H15N3O4S, CAS 423736-05-4
2-[2-(3-Nitroanilino)-2-oxoethyl]sulfanyl-N-phenylacetamide
CAS 423736-05-4C16H15N3O4S
2-{[2-(2,4-Dichloro-5-methoxyanilino)-2-oxoethyl]sulfanyl}-N-methyl-N-phenylacetamide chemical structure, C18H18Cl2N2O3S, CAS 341965-20-6
2-{[2-(2,4-Dichloro-5-methoxyanilino)-2-oxoethyl]sulfanyl}-N-methyl-N-phenylacetamide
CAS 341965-20-6C18H18Cl2N2O3S
2-[2-(4-Methyl-3-nitroanilino)-2-oxoethyl]sulfanyl-N-phenylacetamide chemical structure, C17H17N3O4S, CAS 432002-88-5
2-[2-(4-Methyl-3-nitroanilino)-2-oxoethyl]sulfanyl-N-phenylacetamide
CAS 432002-88-5C17H17N3O4S
2-[2-(4-Bromo-3-methylanilino)-2-oxoethyl]sulfanyl-N-phenylacetamide chemical structure, C17H17BrN2O2S, CAS 431977-75-2
2-[2-(4-Bromo-3-methylanilino)-2-oxoethyl]sulfanyl-N-phenylacetamide
CAS 431977-75-2C17H17BrN2O2S
2-[2-(4-Acetylanilino)-2-oxoethyl]sulfanyl-N-phenylacetamide chemical structure, C18H18N2O3S, CAS 327992-30-3
2-[2-(4-Acetylanilino)-2-oxoethyl]sulfanyl-N-phenylacetamide
CAS 327992-30-3C18H18N2O3S
2,2'-Sulfanediylbis(N-methyl-N-phenylacetamide) chemical structure, C18H20N2O2S, CAS 34866-69-8
2,2'-Sulfanediylbis(N-methyl-N-phenylacetamide)
CAS 34866-69-8C18H20N2O2S
2,2'-Sulfanediylbis[N-(3,5-di-tert-butyl-4-hydroxyphenyl)acetamide] chemical structure, C32H48N2O4S, CAS 29414-01-5
2,2'-Sulfanediylbis[N-(3,5-di-tert-butyl-4-hydroxyphenyl)acetamide]
CAS 29414-01-5C32H48N2O4S