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Murcko scaffold

Ring system with 4 rings and 24 atoms

110 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 24
Chemicals: 110
With full pages: 15

Scaffold SMILES

O=c1cc(CN2CCN(c3ccccc3)CC2)c2ccccc2o1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=c1cc(CN2CCN(c3ccccc3)CC2)c2ccccc2o1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 49 to 96 of 110 chemicals

4-{[4-(4-Fluorophenyl)piperazin-1-yl]methyl}-7-methyl-2H-chromen-2-one chemical structure, C21H21FN2O2, CAS 877781-98-1

4-{[4-(4-Fluorophenyl)piperazin-1-yl]methyl}-7-methyl-2H-chromen-2-one

CAS 877781-98-1C₂₁H₂₁FN₂O₂

4-{[4-(2-Fluorophenyl)piperazin-1-yl]methyl}-6-(propan-2-yl)-2H-chromen-2-one chemical structure, C23H25FN2O2, CAS 877783-53-4

4-{[4-(2-Fluorophenyl)piperazin-1-yl]methyl}-6-(propan-2-yl)-2H-chromen-2-one

CAS 877783-53-4C₂₃H₂₅FN₂O₂

6-Chloro-4-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-5,7-dimethyl-2H-chromen-2-one chemical structure, C22H22ClFN2O2, CAS 877792-50-2

6-Chloro-4-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-5,7-dimethyl-2H-chromen-2-one

CAS 877792-50-2C₂₂H₂₂ClFN₂O₂

6-Chloro-4-((4-(4-fluorophenyl)piperazin-1-yl)methyl)-5,7-dimethyl-2H-chromen-2-one chemical structure, C22H22ClFN2O2, CAS 877777-46-3

6-Chloro-4-((4-(4-fluorophenyl)piperazin-1-yl)methyl)-5,7-dimethyl-2H-chromen-2-one

CAS 877777-46-3C₂₂H₂₂ClFN₂O₂

4-{[4-(4-Methoxyphenyl)piperazin-1-yl]methyl}-6,8-dimethyl-2H-chromen-2-one chemical structure, C23H26N2O3, CAS 877798-29-3

4-{[4-(4-Methoxyphenyl)piperazin-1-yl]methyl}-6,8-dimethyl-2H-chromen-2-one

CAS 877798-29-3C₂₃H₂₆N₂O₃

4-{[4-(4-Methoxyphenyl)piperazin-1-yl]methyl}-5,7-dimethyl-2H-chromen-2-one chemical structure, C23H26N2O3, CAS 877647-90-0

4-{[4-(4-Methoxyphenyl)piperazin-1-yl]methyl}-5,7-dimethyl-2H-chromen-2-one

CAS 877647-90-0C₂₃H₂₆N₂O₃

7-Methyl-4-[(4-phenylpiperazin-1-yl)methyl]chromen-2-one chemical structure, C21H22N2O2, CAS 877805-29-3

7-Methyl-4-[(4-phenylpiperazin-1-yl)methyl]chromen-2-one

CAS 877805-29-3C₂₁H₂₂N₂O₂

4-((4-(4-Fluorophenyl)piperazin-1-yl)methyl)-7,8-dimethyl-2H-chromen-2-one chemical structure, C22H23FN2O2, CAS 877786-58-8

4-((4-(4-Fluorophenyl)piperazin-1-yl)methyl)-7,8-dimethyl-2H-chromen-2-one

CAS 877786-58-8C₂₂H₂₃FN₂O₂

4-((4-(4-Methoxyphenyl)piperazin-1-yl)methyl)-5,7,8-trimethyl-2H-chromen-2-one chemical structure, C24H28N2O3, CAS 862193-57-5

4-((4-(4-Methoxyphenyl)piperazin-1-yl)methyl)-5,7,8-trimethyl-2H-chromen-2-one

CAS 862193-57-5C₂₄H₂₈N₂O₃

4-{[4-(2-Fluorophenyl)piperazin-1-yl]methyl}-6-methyl-2H-chromen-2-one chemical structure, C21H21FN2O2, CAS 877782-66-6

4-{[4-(2-Fluorophenyl)piperazin-1-yl]methyl}-6-methyl-2H-chromen-2-one

CAS 877782-66-6C₂₁H₂₁FN₂O₂

4-{[4-(3-Chlorophenyl)piperazin-1-yl]methyl}-5,7,8-trimethyl-2H-chromen-2-one chemical structure, C23H25ClN2O2, CAS 877788-15-3

4-{[4-(3-Chlorophenyl)piperazin-1-yl]methyl}-5,7,8-trimethyl-2H-chromen-2-one

CAS 877788-15-3C₂₃H₂₅ClN₂O₂

6-Chloro-4-((4-(3-chlorophenyl)piperazin-1-yl)methyl)-5,7-dimethyl-2H-chromen-2-one chemical structure, C22H22Cl2N2O2, CAS 877797-55-2

6-Chloro-4-((4-(3-chlorophenyl)piperazin-1-yl)methyl)-5,7-dimethyl-2H-chromen-2-one

CAS 877797-55-2C₂₂H₂₂Cl₂N₂O₂

4-{[4-(4-Fluorophenyl)piperazin-1-yl]methyl}-6,8-dimethyl-2H-chromen-2-one chemical structure, C22H23FN2O2, CAS 877802-16-9

4-{[4-(4-Fluorophenyl)piperazin-1-yl]methyl}-6,8-dimethyl-2H-chromen-2-one

CAS 877802-16-9C₂₂H₂₃FN₂O₂

4-((4-(2-Fluorophenyl)piperazin-1-yl)methyl)-6-hydroxy-7-methyl-2H-chromen-2-one chemical structure, C21H21FN2O3, CAS 877797-92-7

4-((4-(2-Fluorophenyl)piperazin-1-yl)methyl)-6-hydroxy-7-methyl-2H-chromen-2-one

CAS 877797-92-7C₂₁H₂₁FN₂O₃

4-((4-(2-Fluorophenyl)piperazin-1-yl)methyl)-7-methyl-2H-chromen-2-one chemical structure, C21H21FN2O2, CAS 877804-73-4

4-((4-(2-Fluorophenyl)piperazin-1-yl)methyl)-7-methyl-2H-chromen-2-one

CAS 877804-73-4C₂₁H₂₁FN₂O₂

5,7-Dimethyl-4-[(4-phenylpiperazin-1-yl)methyl]chromen-2-one chemical structure, C22H24N2O2, CAS 862488-44-6

5,7-Dimethyl-4-[(4-phenylpiperazin-1-yl)methyl]chromen-2-one

CAS 862488-44-6C₂₂H₂₄N₂O₂

4-((4-(2-Fluorophenyl)piperazin-1-yl)methyl)-6,8-dimethyl-2H-chromen-2-one chemical structure, C22H23FN2O2, CAS 877786-34-0

4-((4-(2-Fluorophenyl)piperazin-1-yl)methyl)-6,8-dimethyl-2H-chromen-2-one

CAS 877786-34-0C₂₂H₂₃FN₂O₂

4-((4-(2-Fluorophenyl)piperazin-1-yl)methyl)-6-hydroxy-2H-chromen-2-one chemical structure, C20H19FN2O3, CAS 877802-53-4

4-((4-(2-Fluorophenyl)piperazin-1-yl)methyl)-6-hydroxy-2H-chromen-2-one

CAS 877802-53-4C₂₀H₁₉FN₂O₃

4-{[4-(2-Fluorophenyl)piperazin-1-yl]methyl}-5,7,8-trimethyl-2H-chromen-2-one chemical structure, C23H25FN2O2, CAS 877795-67-0

4-{[4-(2-Fluorophenyl)piperazin-1-yl]methyl}-5,7,8-trimethyl-2H-chromen-2-one

CAS 877795-67-0C₂₃H₂₅FN₂O₂

6,7-Dimethyl-4-[(4-phenylpiperazin-1-yl)methyl]chromen-2-one chemical structure, C22H24N2O2, CAS 850030-35-2

6,7-Dimethyl-4-[(4-phenylpiperazin-1-yl)methyl]chromen-2-one

CAS 850030-35-2C₂₂H₂₄N₂O₂

4-{[4-(2-Fluorophenyl)piperazin-1-yl]methyl}-5,7-dimethyl-2H-chromen-2-one chemical structure, C22H23FN2O2, CAS 862489-47-2

4-{[4-(2-Fluorophenyl)piperazin-1-yl]methyl}-5,7-dimethyl-2H-chromen-2-one

CAS 862489-47-2C₂₂H₂₃FN₂O₂

4-((4-(2-Methoxyphenyl)piperazin-1-yl)methyl)-6,8-dimethyl-2H-chromen-2-one chemical structure, C23H26N2O3, CAS 902322-61-6

4-((4-(2-Methoxyphenyl)piperazin-1-yl)methyl)-6,8-dimethyl-2H-chromen-2-one

CAS 902322-61-6C₂₃H₂₆N₂O₃

6-Hydroxy-4-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]chromen-2-one chemical structure, C21H22N2O4, CAS 902020-22-8

6-Hydroxy-4-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]chromen-2-one

CAS 902020-22-8C₂₁H₂₂N₂O₄

6-Ethyl-4-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]chromen-2-one chemical structure, C23H26N2O3, CAS 902034-05-3

6-Ethyl-4-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]chromen-2-one

CAS 902034-05-3C₂₃H₂₆N₂O₃