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Murcko scaffold

Ring system with 4 rings and 24 atoms

110 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
24
Chemicals
110
With full pages
15
Scaffold SMILES

O=c1cc(CN2CCN(c3ccccc3)CC2)c2ccccc2o1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1cc(CN2CCN(c3ccccc3)CC2)c2ccccc2o1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 97 to 110 of 110 chemicals

6-Chloro-7-hydroxy-4-[[4-(4-methoxyphenyl)piperazin-1-yl]methyl]chromen-2-one chemical structure, C21H21ClN2O4, CAS 849459-02-5
6-Chloro-7-hydroxy-4-[[4-(4-methoxyphenyl)piperazin-1-yl]methyl]chromen-2-one
CAS 849459-02-5C21H21ClN2O4
7-Hydroxy-4-((4-(2-methoxyphenyl)piperazin-1-yl)methyl)-8-methyl-2H-chromen-2-one chemical structure, C22H24N2O4, CAS 850150-54-8
7-Hydroxy-4-((4-(2-methoxyphenyl)piperazin-1-yl)methyl)-8-methyl-2H-chromen-2-one
CAS 850150-54-8C22H24N2O4
4-((4-(3-Chlorophenyl)piperazin-1-yl)methyl)-6-ethyl-7-hydroxy-2H-chromen-2-one chemical structure, C22H23ClN2O3, CAS 849533-03-5
4-((4-(3-Chlorophenyl)piperazin-1-yl)methyl)-6-ethyl-7-hydroxy-2H-chromen-2-one
CAS 849533-03-5C22H23ClN2O3
7,8-Dihydroxy-4-{[4-(2-methoxyphenyl)piperazin-1-yl]methyl}-2H-chromen-2-one chemical structure, C21H22N2O5, CAS 902305-77-5
7,8-Dihydroxy-4-{[4-(2-methoxyphenyl)piperazin-1-yl]methyl}-2H-chromen-2-one
CAS 902305-77-5C21H22N2O5
4-{[4-(2,5-Dimethylphenyl)piperazin-1-yl]methyl}-5,7-dimethyl-2H-chromen-2-one chemical structure, C24H28N2O2, CAS 931586-31-1
4-{[4-(2,5-Dimethylphenyl)piperazin-1-yl]methyl}-5,7-dimethyl-2H-chromen-2-one
CAS 931586-31-1C24H28N2O2
4-{[4-(5-Chloro-2-methylphenyl)piperazin-1-yl]methyl}-5,7-dimethyl-2H-chromen-2-one chemical structure, C23H25ClN2O2, CAS 931586-47-9
4-{[4-(5-Chloro-2-methylphenyl)piperazin-1-yl]methyl}-5,7-dimethyl-2H-chromen-2-one
CAS 931586-47-9C23H25ClN2O2
6-Chloro-4-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-2H-chromen-2-one chemical structure, C20H18ClFN2O2, CAS 919735-60-7
6-Chloro-4-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-2H-chromen-2-one
CAS 919735-60-7C20H18ClFN2O2
4-((4-(3-Chlorophenyl)piperazin-1-yl)methyl)-6-ethyl-2H-chromen-2-one hydrochloride chemical structure, C22H24Cl2N2O2, CAS 1177436-90-6
4-((4-(3-Chlorophenyl)piperazin-1-yl)methyl)-6-ethyl-2H-chromen-2-one hydrochloride
CAS 1177436-90-6C22H24Cl2N2O2
4-((4-(3-Chlorophenyl)piperazin-1-yl)methyl)-6-isopropyl-2H-chromen-2-one dihydrochloride chemical structure, C23H27Cl3N2O2, CAS 1177126-42-9
4-((4-(3-Chlorophenyl)piperazin-1-yl)methyl)-6-isopropyl-2H-chromen-2-one dihydrochloride
CAS 1177126-42-9C23H27Cl3N2O2
6-Isopropyl-4-((4-(2-methoxyphenyl)piperazin-1-yl)methyl)-2H-chromen-2-one dihydrochloride chemical structure, C24H30Cl2N2O3, CAS 1177816-69-1
6-Isopropyl-4-((4-(2-methoxyphenyl)piperazin-1-yl)methyl)-2H-chromen-2-one dihydrochloride
CAS 1177816-69-1C24H30Cl2N2O3
7,8-Dihydroxy-4-((4-(4-methoxyphenyl)piperazin-1-yl)methyl)-2H-chromen-2-one dihydrochloride chemical structure, C21H24Cl2N2O5, CAS 1177724-15-0
7,8-Dihydroxy-4-((4-(4-methoxyphenyl)piperazin-1-yl)methyl)-2H-chromen-2-one dihydrochloride
CAS 1177724-15-0C21H24Cl2N2O5
4-((4-(3-Chlorophenyl)piperazin-1-yl)methyl)-7,8-dihydroxy-2H-chromen-2-one dihydrochloride chemical structure, C20H21Cl3N2O4, CAS 1177926-15-6
4-((4-(3-Chlorophenyl)piperazin-1-yl)methyl)-7,8-dihydroxy-2H-chromen-2-one dihydrochloride
CAS 1177926-15-6C20H21Cl3N2O4
6-Ethyl-4-((4-phenylpiperazin-1-yl)methyl)-2H-chromen-2-one dihydrochloride chemical structure, C22H26Cl2N2O2, CAS 1177911-44-2
6-Ethyl-4-((4-phenylpiperazin-1-yl)methyl)-2H-chromen-2-one dihydrochloride
CAS 1177911-44-2C22H26Cl2N2O2
6-Chloro-4-((4-(2-methoxyphenyl)piperazin-1-yl)methyl)-2H-chromen-2-one dihydrochloride chemical structure, C21H23Cl3N2O3, CAS 1177807-72-5
6-Chloro-4-((4-(2-methoxyphenyl)piperazin-1-yl)methyl)-2H-chromen-2-one dihydrochloride
CAS 1177807-72-5C21H23Cl3N2O3