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Murcko scaffold

1,2,3,4-Tetrahydro-1,8-naphthyridin-2-one scaffold

57 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
11
Chemicals
57
With full pages
9
Scaffold SMILES

O=C1CCc2cccnc2N1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1,2,3,4-Tetrahydro-1,8-naphthyridin-2-one page
Murcko scaffold O=C1CCc2cccnc2N1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 57 chemicals

tert-Butyl (E)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylate chemical structure, C15H18N2O3, CAS 527758-07-2
tert-Butyl (E)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylate
CAS 527758-07-2C15H18N2O3
6-Bromo-3,4-dihydro-1,8-naphthyridin-2(1H)-one chemical structure, C8H7BrN2O, CAS 129686-16-4
6-Bromo-3,4-dihydro-1,8-naphthyridin-2(1H)-one
CAS 129686-16-4C8H7BrN2O
Methyl 6-bromo-2-oxo-1,2,3,4-tetrahydro-1,8-naphthyridine-3-carboxylate chemical structure, C10H9BrN2O3, CAS 335031-10-2
Methyl 6-bromo-2-oxo-1,2,3,4-tetrahydro-1,8-naphthyridine-3-carboxylate
CAS 335031-10-2C10H9BrN2O3
3-Amino-3,4-dihydro-1,8-naphthyridin-2(1H)-one chemical structure, C8H9N3O, CAS 847684-77-9
3-Amino-3,4-dihydro-1,8-naphthyridin-2(1H)-one
CAS 847684-77-9C8H9N3O
(E)-3-(7-Oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylic acid chemical structure, C11H10N2O3, CAS 527758-08-3
(E)-3-(7-Oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylic acid
CAS 527758-08-3C11H10N2O3
1,2,3,4-Tetrahydro-1,8-naphthyridin-2-one chemical structure, C8H8N2O, CAS 40000-79-1
1,2,3,4-Tetrahydro-1,8-naphthyridin-2-one
CAS 40000-79-1C8H8N2O
6-Bromo-1-methyl-3,4-dihydro-1,8-naphthyridin-2(1H)-one chemical structure, C9H9BrN2O, CAS 129686-17-5
6-Bromo-1-methyl-3,4-dihydro-1,8-naphthyridin-2(1H)-one
CAS 129686-17-5C9H9BrN2O
6-Vinyl-3,4-dihydro-1H-[1,8]naphthyridin-2-one chemical structure, C10H10N2O, CAS 443956-56-7
6-Vinyl-3,4-dihydro-1H-[1,8]naphthyridin-2-one
CAS 443956-56-7C10H10N2O
7-Oxo-5,6,7,8-tetrahydro-1,8-naphthyridine-3-carbaldehyde chemical structure, C9H8N2O2, CAS 443956-57-8
7-Oxo-5,6,7,8-tetrahydro-1,8-naphthyridine-3-carbaldehyde
CAS 443956-57-8C9H8N2O2
6-Methyl-3,4-dihydro-1,8-naphthyridin-2(1H)-one chemical structure, C9H10N2O, CAS 1222533-73-4
6-Methyl-3,4-dihydro-1,8-naphthyridin-2(1H)-one
CAS 1222533-73-4C9H10N2O
4-((7-Oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)oxy)butanal chemical structure, C12H14N2O3, CAS 846031-27-4
4-((7-Oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)oxy)butanal
CAS 846031-27-4C12H14N2O3
7-(4-Chlorobutoxy)-3,4-dihydro-1,8-naphthyridin-2(1H)-one chemical structure, C12H15ClN2O2, CAS 846033-38-3
7-(4-Chlorobutoxy)-3,4-dihydro-1,8-naphthyridin-2(1H)-one
CAS 846033-38-3C12H15ClN2O2
7-(4-Hydroxybutoxy)-3,4-dihydro-1,8-naphthyridin-2(1H)-one chemical structure, C12H16N2O3, CAS 846031-25-2
7-(4-Hydroxybutoxy)-3,4-dihydro-1,8-naphthyridin-2(1H)-one
CAS 846031-25-2C12H16N2O3
7-Amino-4,4-dimethyl-3,4-dihydro-1,8-naphthyridin-2(1H)-one chemical structure, C10H13N3O, CAS 618446-06-3
7-Amino-4,4-dimethyl-3,4-dihydro-1,8-naphthyridin-2(1H)-one
CAS 618446-06-3C10H13N3O
7-Chloro-3,4-dihydro-1,8-naphthyridin-2(1H)-one chemical structure, C8H7ClN2O, CAS 846034-67-1
7-Chloro-3,4-dihydro-1,8-naphthyridin-2(1H)-one
CAS 846034-67-1C8H7ClN2O
7-Fluoro-4,4-dimethyl-1,2,3,4-tetrahydro-1,8-naphthyridin-2-one chemical structure, C10H11FN2O, CAS 846035-55-0
7-Fluoro-4,4-dimethyl-1,2,3,4-tetrahydro-1,8-naphthyridin-2-one
CAS 846035-55-0C10H11FN2O
7-Oxo-5,6,7,8-tetrahydro-1,8-naphthyridine-2-carboxylic acid chemical structure, C9H8N2O3, CAS 615568-70-2
7-Oxo-5,6,7,8-tetrahydro-1,8-naphthyridine-2-carboxylic acid
CAS 615568-70-2C9H8N2O3
7-Oxo-5,6,7,8-tetrahydro-1,8-naphthyridine-2-carbaldehyde chemical structure, C9H8N2O2, CAS 615568-72-4
7-Oxo-5,6,7,8-tetrahydro-1,8-naphthyridine-2-carbaldehyde
CAS 615568-72-4C9H8N2O2
7-(Hydroxymethyl)-3,4-dihydro-1,8-naphthyridin-2(1H)-one chemical structure, C9H10N2O2, CAS 615568-71-3
7-(Hydroxymethyl)-3,4-dihydro-1,8-naphthyridin-2(1H)-one
CAS 615568-71-3C9H10N2O2
6-Bromo-2-oxo-1,2,3,4-tetrahydro-1,8-naphthyridine-3-carboxylic acid chemical structure, C9H7BrN2O3, CAS 1196154-23-0
6-Bromo-2-oxo-1,2,3,4-tetrahydro-1,8-naphthyridine-3-carboxylic acid
CAS 1196154-23-0C9H7BrN2O3
5-Methoxy-3,4-dihydro-1,8-naphthyridin-2(1H)-one chemical structure, C9H10N2O2, CAS 1045855-18-2
5-Methoxy-3,4-dihydro-1,8-naphthyridin-2(1H)-one
CAS 1045855-18-2C9H10N2O2
5-Fluoro-3,4-dihydro-1,8-naphthyridin-2(1H)-one chemical structure, C8H7FN2O, CAS 1237535-78-2
5-Fluoro-3,4-dihydro-1,8-naphthyridin-2(1H)-one
CAS 1237535-78-2C8H7FN2O
5-Chloro-3,4-dihydro-1,8-naphthyridin-2(1H)-one chemical structure, C8H7ClN2O, CAS 1237535-79-3
5-Chloro-3,4-dihydro-1,8-naphthyridin-2(1H)-one
CAS 1237535-79-3C8H7ClN2O
6-Fluoro-3,4-dihydro-1,8-naphthyridin-2(1H)-one chemical structure, C8H7FN2O, CAS 1222533-77-8
6-Fluoro-3,4-dihydro-1,8-naphthyridin-2(1H)-one
CAS 1222533-77-8C8H7FN2O