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Murcko scaffold

Ring system with 4 rings and 25 atoms

31 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
31
With full pages
1
Scaffold SMILES

O=c1c(Oc2ccccc2)coc2c(CN3CCCCC3)cccc12

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1c(Oc2ccccc2)coc2c(CN3CCCCC3)cccc12

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 31 of 31 chemicals

3-(2-Bromophenoxy)-7-hydroxy-8-(piperidin-1-ylmethyl)-2-(trifluoromethyl)-4H-chromen-4-one chemical structure, C22H19BrF3NO4, CAS 303121-66-6
3-(2-Bromophenoxy)-7-hydroxy-8-(piperidin-1-ylmethyl)-2-(trifluoromethyl)-4H-chromen-4-one
CAS 303121-66-6C22H19BrF3NO4
7-Hydroxy-3-(3-methylphenoxy)-8-[(4-methylpiperidin-1-yl)methyl]-2-(trifluoromethyl)-4H-chromen-4-one chemical structure, C24H24F3NO4, CAS 329225-42-5
7-Hydroxy-3-(3-methylphenoxy)-8-[(4-methylpiperidin-1-yl)methyl]-2-(trifluoromethyl)-4H-chromen-4-one
CAS 329225-42-5C24H24F3NO4
7-Hydroxy-3-(4-methoxyphenoxy)-8-(piperidin-1-ylmethyl)-2-(trifluoromethyl)-4H-chromen-4-one chemical structure, C23H22F3NO5, CAS 302952-70-1
7-Hydroxy-3-(4-methoxyphenoxy)-8-(piperidin-1-ylmethyl)-2-(trifluoromethyl)-4H-chromen-4-one
CAS 302952-70-1C23H22F3NO5
8-[(2-Ethylpiperidin-1-yl)methyl]-7-hydroxy-3-(4-methoxyphenoxy)-2-(trifluoromethyl)chromen-4-one chemical structure, C25H26F3NO5, CAS 302952-74-5
8-[(2-Ethylpiperidin-1-yl)methyl]-7-hydroxy-3-(4-methoxyphenoxy)-2-(trifluoromethyl)chromen-4-one
CAS 302952-74-5C25H26F3NO5
3-(3,5-Dimethylphenoxy)-7-hydroxy-8-(1-piperidinylmethyl)-2-(trifluoromethyl)-4H-chromen-4-one chemical structure, C24H24F3NO4, CAS 329224-91-1
3-(3,5-Dimethylphenoxy)-7-hydroxy-8-(1-piperidinylmethyl)-2-(trifluoromethyl)-4H-chromen-4-one
CAS 329224-91-1C24H24F3NO4
3-(3,4-Dimethylphenoxy)-7-hydroxy-8-[(4-methylpiperidin-1-yl)methyl]-2-(trifluoromethyl)chromen-4-one chemical structure, C25H26F3NO4, CAS 685861-30-7
3-(3,4-Dimethylphenoxy)-7-hydroxy-8-[(4-methylpiperidin-1-yl)methyl]-2-(trifluoromethyl)chromen-4-one
CAS 685861-30-7C25H26F3NO4
3-(4-Chlorophenoxy)-7-hydroxy-8-(piperidin-1-ylmethyl)-2-(trifluoromethyl)chromen-4-one chemical structure, C22H19ClF3NO4, CAS 685861-35-2
3-(4-Chlorophenoxy)-7-hydroxy-8-(piperidin-1-ylmethyl)-2-(trifluoromethyl)chromen-4-one
CAS 685861-35-2C22H19ClF3NO4
7-Hydroxy-3-(4-methoxyphenoxy)-8-(piperidin-1-ylmethyl)-4H-chromen-4-one chemical structure, C22H23NO5, CAS 637751-84-9
7-Hydroxy-3-(4-methoxyphenoxy)-8-(piperidin-1-ylmethyl)-4H-chromen-4-one
CAS 637751-84-9C22H23NO5
7-Hydroxy-3-(3-methoxyphenoxy)-8-(piperidin-1-ylmethyl)-2-(trifluoromethyl)chromen-4-one chemical structure, C23H22F3NO5, CAS 637751-89-4
7-Hydroxy-3-(3-methoxyphenoxy)-8-(piperidin-1-ylmethyl)-2-(trifluoromethyl)chromen-4-one
CAS 637751-89-4C23H22F3NO5
Ethyl 4-[7-hydroxy-4-oxo-8-(piperidylmethyl)chromen-3-yloxy]benzoate chemical structure, C24H25NO6, CAS 637751-92-9
Ethyl 4-[7-hydroxy-4-oxo-8-(piperidylmethyl)chromen-3-yloxy]benzoate
CAS 637751-92-9C24H25NO6
Methyl 4-[7-hydroxy-4-oxo-8-(piperidylmethyl)chromen-3-yloxy]benzoate chemical structure, C23H23NO6, CAS 637752-59-1
Methyl 4-[7-hydroxy-4-oxo-8-(piperidylmethyl)chromen-3-yloxy]benzoate
CAS 637752-59-1C23H23NO6
Ethyl 4-((7-hydroxy-4-oxo-8-(piperidin-1-ylmethyl)-2-(trifluoromethyl)-4H-chromen-3-yl)oxy)benzoate chemical structure, C25H24F3NO6, CAS 637752-62-6
Ethyl 4-((7-hydroxy-4-oxo-8-(piperidin-1-ylmethyl)-2-(trifluoromethyl)-4H-chromen-3-yl)oxy)benzoate
CAS 637752-62-6C25H24F3NO6
Methyl 4-((7-hydroxy-2-methyl-4-oxo-8-(piperidin-1-ylmethyl)-4H-chromen-3-yl)oxy)benzoate chemical structure, C24H25NO6, CAS 637753-32-3
Methyl 4-((7-hydroxy-2-methyl-4-oxo-8-(piperidin-1-ylmethyl)-4H-chromen-3-yl)oxy)benzoate
CAS 637753-32-3C24H25NO6
7-Hydroxy-3-(4-methoxyphenoxy)-2-methyl-8-[(4-methylpiperidin-1-yl)methyl]-4H-chromen-4-one chemical structure, C24H27NO5, CAS 847339-97-3
7-Hydroxy-3-(4-methoxyphenoxy)-2-methyl-8-[(4-methylpiperidin-1-yl)methyl]-4H-chromen-4-one
CAS 847339-97-3C24H27NO5
7-Hydroxy-3-(3-methoxyphenoxy)-2-methyl-8-[(4-methylpiperidin-1-yl)methyl]-4H-chromen-4-one chemical structure, C24H27NO5, CAS 845666-55-9
7-Hydroxy-3-(3-methoxyphenoxy)-2-methyl-8-[(4-methylpiperidin-1-yl)methyl]-4H-chromen-4-one
CAS 845666-55-9C24H27NO5
7-Hydroxy-3-(3-methoxyphenoxy)-8-((2-methylpiperidin-1-yl)methyl)-2-(trifluoromethyl)-4H-chromen-4-one chemical structure, C24H24F3NO5, CAS 845663-01-6
7-Hydroxy-3-(3-methoxyphenoxy)-8-((2-methylpiperidin-1-yl)methyl)-2-(trifluoromethyl)-4H-chromen-4-one
CAS 845663-01-6C24H24F3NO5
3-(2-Bromophenoxy)-7-hydroxy-8-((2-methylpiperidin-1-yl)methyl)-4H-chromen-4-one chemical structure, C22H22BrNO4, CAS 844860-47-5
3-(2-Bromophenoxy)-7-hydroxy-8-((2-methylpiperidin-1-yl)methyl)-4H-chromen-4-one
CAS 844860-47-5C22H22BrNO4
Ethyl 4-({7-hydroxy-2-methyl-8-[(2-methylpiperidin-1-yl)methyl]-4-oxo-4H-chromen-3-yl}oxy)benzoate chemical structure, C26H29NO6, CAS 847040-26-0
Ethyl 4-({7-hydroxy-2-methyl-8-[(2-methylpiperidin-1-yl)methyl]-4-oxo-4H-chromen-3-yl}oxy)benzoate
CAS 847040-26-0C26H29NO6
7-Hydroxy-3-(4-methoxyphenoxy)-2-methyl-8-(piperidin-1-ylmethyl)-4H-chromen-4-one chemical structure, C23H25NO5, CAS 637753-31-2
7-Hydroxy-3-(4-methoxyphenoxy)-2-methyl-8-(piperidin-1-ylmethyl)-4H-chromen-4-one
CAS 637753-31-2C23H25NO5
7-Hydroxy-3-(2-methoxyphenoxy)-8-((3-methylpiperidin-1-yl)methyl)-4H-chromen-4-one chemical structure, C23H25NO5, CAS 845798-86-9
7-Hydroxy-3-(2-methoxyphenoxy)-8-((3-methylpiperidin-1-yl)methyl)-4H-chromen-4-one
CAS 845798-86-9C23H25NO5
Methyl 4-((7-hydroxy-8-((4-methylpiperidin-1-yl)methyl)-4-oxo-4H-chromen-3-yl)oxy)benzoate chemical structure, C24H25NO6, CAS 847185-23-3
Methyl 4-((7-hydroxy-8-((4-methylpiperidin-1-yl)methyl)-4-oxo-4H-chromen-3-yl)oxy)benzoate
CAS 847185-23-3C24H25NO6
Methyl 4-((7-hydroxy-8-((2-methylpiperidin-1-yl)methyl)-4-oxo-4H-chromen-3-yl)oxy)benzoate chemical structure, C24H25NO6, CAS 847916-69-2
Methyl 4-((7-hydroxy-8-((2-methylpiperidin-1-yl)methyl)-4-oxo-4H-chromen-3-yl)oxy)benzoate
CAS 847916-69-2C24H25NO6
7-Hydroxy-3-(2-methoxyphenoxy)-2-methyl-8-(piperidin-1-ylmethyl)-4H-chromen-4-one chemical structure, C23H25NO5, CAS 637751-95-2
7-Hydroxy-3-(2-methoxyphenoxy)-2-methyl-8-(piperidin-1-ylmethyl)-4H-chromen-4-one
CAS 637751-95-2C23H25NO5
7-Hydroxy-3-(2-methoxyphenoxy)-8-((2-methylpiperidin-1-yl)methyl)-4H-chromen-4-one chemical structure, C23H25NO5, CAS 847340-31-2
7-Hydroxy-3-(2-methoxyphenoxy)-8-((2-methylpiperidin-1-yl)methyl)-4H-chromen-4-one
CAS 847340-31-2C23H25NO5