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Murcko scaffold

Ring system with 4 rings and 25 atoms

23 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
23
With full pages
6
Scaffold SMILES

O=c1c(Oc2ccccc2)coc2c(CN3CCOCC3)cccc12

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1c(Oc2ccccc2)coc2c(CN3CCOCC3)cccc12

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 23 of 23 chemicals

3-(2-Bromophenoxy)-7-hydroxy-8-(4-morpholinylmethyl)-2-(trifluoromethyl)-4H-chromen-4-one chemical structure, C21H17BrF3NO5, CAS 303121-67-7
3-(2-Bromophenoxy)-7-hydroxy-8-(4-morpholinylmethyl)-2-(trifluoromethyl)-4H-chromen-4-one
CAS 303121-67-7C21H17BrF3NO5
7-Hydroxy-3-(3-methoxyphenoxy)-2-methyl-8-(morpholin-4-ylmethyl)chromen-4-one chemical structure, C22H23NO6, CAS 845901-43-1
7-Hydroxy-3-(3-methoxyphenoxy)-2-methyl-8-(morpholin-4-ylmethyl)chromen-4-one
CAS 845901-43-1C22H23NO6
7-Hydroxy-3-(3-methoxyphenoxy)-8-(morpholinomethyl)-4H-chromen-4-one chemical structure, C21H21NO6, CAS 847160-29-6
7-Hydroxy-3-(3-methoxyphenoxy)-8-(morpholinomethyl)-4H-chromen-4-one
CAS 847160-29-6C21H21NO6
3-(3,5-Dimethylphenoxy)-7-hydroxy-8-(morpholin-4-ylmethyl)-2-(trifluoromethyl)chromen-4-one chemical structure, C23H22F3NO5, CAS 307544-07-6
3-(3,5-Dimethylphenoxy)-7-hydroxy-8-(morpholin-4-ylmethyl)-2-(trifluoromethyl)chromen-4-one
CAS 307544-07-6C23H22F3NO5
7-Hydroxy-8-(morpholin-4-ylmethyl)-3-(4-propylphenoxy)-2-(trifluoromethyl)chromen-4-one chemical structure, C24H24F3NO5, CAS 685861-16-9
7-Hydroxy-8-(morpholin-4-ylmethyl)-3-(4-propylphenoxy)-2-(trifluoromethyl)chromen-4-one
CAS 685861-16-9C24H24F3NO5
7-Hydroxy-8-(morpholin-4-ylmethyl)-2-(trifluoromethyl)-3-(2,3,5-trimethylphenoxy)chromen-4-one chemical structure, C24H24F3NO5, CAS 685861-22-7
7-Hydroxy-8-(morpholin-4-ylmethyl)-2-(trifluoromethyl)-3-(2,3,5-trimethylphenoxy)chromen-4-one
CAS 685861-22-7C24H24F3NO5
3-(3,4-Dimethylphenoxy)-7-hydroxy-8-(morpholin-4-ylmethyl)-2-(trifluoromethyl)chromen-4-one chemical structure, C23H22F3NO5, CAS 685861-28-3
3-(3,4-Dimethylphenoxy)-7-hydroxy-8-(morpholin-4-ylmethyl)-2-(trifluoromethyl)chromen-4-one
CAS 685861-28-3C23H22F3NO5
3-(4-Chlorophenoxy)-7-hydroxy-8-(morpholin-4-ylmethyl)-2-(trifluoromethyl)chromen-4-one chemical structure, C21H17ClF3NO5, CAS 685861-34-1
3-(4-Chlorophenoxy)-7-hydroxy-8-(morpholin-4-ylmethyl)-2-(trifluoromethyl)chromen-4-one
CAS 685861-34-1C21H17ClF3NO5
3-(4-Chloro-3-methylphenoxy)-7-hydroxy-8-(morpholin-4-ylmethyl)-2-(trifluoromethyl)chromen-4-one chemical structure, C22H19ClF3NO5, CAS 685861-40-9
3-(4-Chloro-3-methylphenoxy)-7-hydroxy-8-(morpholin-4-ylmethyl)-2-(trifluoromethyl)chromen-4-one
CAS 685861-40-9C22H19ClF3NO5
3-(3,5-Dimethylphenoxy)-7-hydroxy-8-(morpholin-4-ylmethyl)chromen-4-one chemical structure, C22H23NO5, CAS 347365-58-6
3-(3,5-Dimethylphenoxy)-7-hydroxy-8-(morpholin-4-ylmethyl)chromen-4-one
CAS 347365-58-6C22H23NO5
3-(4-tert-Butylphenoxy)-7-hydroxy-8-(morpholin-4-ylmethyl)-2-(trifluoromethyl)chromen-4-one chemical structure, C25H26F3NO5, CAS 302951-22-0
3-(4-tert-Butylphenoxy)-7-hydroxy-8-(morpholin-4-ylmethyl)-2-(trifluoromethyl)chromen-4-one
CAS 302951-22-0C25H26F3NO5
7-Hydroxy-3-(4-methoxyphenoxy)-8-(morpholinomethyl)-2-(trifluoromethyl)-4H-chromen-4-one chemical structure, C22H20F3NO6, CAS 302952-71-2
7-Hydroxy-3-(4-methoxyphenoxy)-8-(morpholinomethyl)-2-(trifluoromethyl)-4H-chromen-4-one
CAS 302952-71-2C22H20F3NO6
Propyl 4-((7-hydroxy-2-methyl-8-(morpholinomethyl)-4-oxo-4H-chromen-3-yl)oxy)benzoate chemical structure, C25H27NO7, CAS 845989-03-9
Propyl 4-((7-hydroxy-2-methyl-8-(morpholinomethyl)-4-oxo-4H-chromen-3-yl)oxy)benzoate
CAS 845989-03-9C25H27NO7
Propyl 4-[7-hydroxy-8-(morpholin-4-ylmethyl)-4-oxochromen-3-yl]oxybenzoate chemical structure, C24H25NO7, CAS 844861-33-2
Propyl 4-[7-hydroxy-8-(morpholin-4-ylmethyl)-4-oxochromen-3-yl]oxybenzoate
CAS 844861-33-2C24H25NO7
8-[(2,6-Dimethylmorpholin-4-yl)methyl]-7-hydroxy-3-(3-methylphenoxy)-2-(trifluoromethyl)-4H-chromen-4-one chemical structure, C24H24F3NO5, CAS 307507-83-1
8-[(2,6-Dimethylmorpholin-4-yl)methyl]-7-hydroxy-3-(3-methylphenoxy)-2-(trifluoromethyl)-4H-chromen-4-one
CAS 307507-83-1C24H24F3NO5
3-(2-Ethoxyphenoxy)-7-hydroxy-2-methyl-8-(morpholin-4-ylmethyl)chromen-4-one chemical structure, C23H25NO6, CAS 844650-11-9
3-(2-Ethoxyphenoxy)-7-hydroxy-2-methyl-8-(morpholin-4-ylmethyl)chromen-4-one
CAS 844650-11-9C23H25NO6
7-Hydroxy-3-(2-methoxyphenoxy)-2-methyl-8-(morpholin-4-ylmethyl)chromen-4-one chemical structure, C22H23NO6, CAS 844858-92-0
7-Hydroxy-3-(2-methoxyphenoxy)-2-methyl-8-(morpholin-4-ylmethyl)chromen-4-one
CAS 844858-92-0C22H23NO6
7-Hydroxy-3-(4-methoxyphenoxy)-2-methyl-8-(morpholin-4-ylmethyl)chromen-4-one chemical structure, C22H23NO6, CAS 845799-01-1
7-Hydroxy-3-(4-methoxyphenoxy)-2-methyl-8-(morpholin-4-ylmethyl)chromen-4-one
CAS 845799-01-1C22H23NO6
3-(2-Ethoxyphenoxy)-7-hydroxy-8-(morpholin-4-ylmethyl)-2-(trifluoromethyl)chromen-4-one chemical structure, C23H22F3NO6, CAS 773151-99-8
3-(2-Ethoxyphenoxy)-7-hydroxy-8-(morpholin-4-ylmethyl)-2-(trifluoromethyl)chromen-4-one
CAS 773151-99-8C23H22F3NO6
3-(2-Bromophenoxy)-7-hydroxy-2-methyl-8-(morpholin-4-ylmethyl)chromen-4-one chemical structure, C21H20BrNO5, CAS 844653-64-1
3-(2-Bromophenoxy)-7-hydroxy-2-methyl-8-(morpholin-4-ylmethyl)chromen-4-one
CAS 844653-64-1C21H20BrNO5
7-Hydroxy-3-(2-methoxyphenoxy)-8-(morpholin-4-ylmethyl)chromen-4-one chemical structure, C21H21NO6, CAS 844460-94-2
7-Hydroxy-3-(2-methoxyphenoxy)-8-(morpholin-4-ylmethyl)chromen-4-one
CAS 844460-94-2C21H21NO6
3-(2-Ethoxyphenoxy)-7-hydroxy-8-(morpholin-4-ylmethyl)chromen-4-one chemical structure, C22H23NO6, CAS 848214-60-8
3-(2-Ethoxyphenoxy)-7-hydroxy-8-(morpholin-4-ylmethyl)chromen-4-one
CAS 848214-60-8C22H23NO6
7-Hydroxy-3-(3-methoxyphenoxy)-8-(morpholin-4-ylmethyl)-2-(trifluoromethyl)chromen-4-one chemical structure, C22H20F3NO6, CAS 848674-42-0
7-Hydroxy-3-(3-methoxyphenoxy)-8-(morpholin-4-ylmethyl)-2-(trifluoromethyl)chromen-4-one
CAS 848674-42-0C22H20F3NO6