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Murcko scaffold

Ring system with 4 rings and 25 atoms

41 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
41
With full pages
8
Scaffold SMILES

O=c1c(Oc2ccccc2)coc2c(CN3CCNCC3)cccc12

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1c(Oc2ccccc2)coc2c(CN3CCNCC3)cccc12

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 41 of 41 chemicals

3-(3,5-Dimethylphenoxy)-8-[(4-ethylpiperazin-1-yl)methyl]-7-hydroxy-2-(trifluoromethyl)chromen-4-one chemical structure, C25H27F3N2O4, CAS 329224-94-4
3-(3,5-Dimethylphenoxy)-8-[(4-ethylpiperazin-1-yl)methyl]-7-hydroxy-2-(trifluoromethyl)chromen-4-one
CAS 329224-94-4C25H27F3N2O4
Methyl 4-({7-hydroxy-2-methyl-8-[(4-methylpiperazin-1-yl)methyl]-4-oxo-4H-chromen-3-yl}oxy)benzoate chemical structure, C24H26N2O6, CAS 844852-48-8
Methyl 4-({7-hydroxy-2-methyl-8-[(4-methylpiperazin-1-yl)methyl]-4-oxo-4H-chromen-3-yl}oxy)benzoate
CAS 844852-48-8C24H26N2O6
3-(2-Ethoxyphenoxy)-7-hydroxy-2-methyl-8-((4-methylpiperazin-1-yl)methyl)-4H-chromen-4-one chemical structure, C24H28N2O5, CAS 844835-75-2
3-(2-Ethoxyphenoxy)-7-hydroxy-2-methyl-8-((4-methylpiperazin-1-yl)methyl)-4H-chromen-4-one
CAS 844835-75-2C24H28N2O5
7-Hydroxy-3-(2-methoxyphenoxy)-8-((4-methylpiperazin-1-yl)methyl)-4H-chromen-4-one chemical structure, C22H24N2O5, CAS 845808-38-0
7-Hydroxy-3-(2-methoxyphenoxy)-8-((4-methylpiperazin-1-yl)methyl)-4H-chromen-4-one
CAS 845808-38-0C22H24N2O5
7-Hydroxy-3-(2-methoxyphenoxy)-2-methyl-8-[(4-methylpiperazin-1-yl)methyl]-4H-chromen-4-one chemical structure, C23H26N2O5, CAS 847036-15-1
7-Hydroxy-3-(2-methoxyphenoxy)-2-methyl-8-[(4-methylpiperazin-1-yl)methyl]-4H-chromen-4-one
CAS 847036-15-1C23H26N2O5
Ethyl 4-({7-hydroxy-2-methyl-8-[(4-methylpiperazin-1-yl)methyl]-4-oxo-4H-chromen-3-yl}oxy)benzoate chemical structure, C25H28N2O6, CAS 847049-28-9
Ethyl 4-({7-hydroxy-2-methyl-8-[(4-methylpiperazin-1-yl)methyl]-4-oxo-4H-chromen-3-yl}oxy)benzoate
CAS 847049-28-9C25H28N2O6
3-(2-Ethoxyphenoxy)-7-hydroxy-8-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)-2-methyl-4H-chromen-4-one chemical structure, C25H30N2O6, CAS 848670-04-2
3-(2-Ethoxyphenoxy)-7-hydroxy-8-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)-2-methyl-4H-chromen-4-one
CAS 848670-04-2C25H30N2O6
7-Hydroxy-8-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)-3-(2-methoxyphenoxy)-2-methyl-4H-chromen-4-one chemical structure, C24H28N2O6, CAS 848207-29-4
7-Hydroxy-8-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)-3-(2-methoxyphenoxy)-2-methyl-4H-chromen-4-one
CAS 848207-29-4C24H28N2O6
Ethyl 4-[(7-hydroxy-8-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}-4-oxo-4H-chromen-3-yl)oxy]benzoate chemical structure, C25H28N2O7, CAS 637753-68-5
Ethyl 4-[(7-hydroxy-8-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}-4-oxo-4H-chromen-3-yl)oxy]benzoate
CAS 637753-68-5C25H28N2O7
Propyl 4-({7-hydroxy-8-[(4-methylpiperazin-1-yl)methyl]-4-oxo-4H-chromen-3-yl}oxy)benzoate chemical structure, C25H28N2O6, CAS 847336-89-4
Propyl 4-({7-hydroxy-8-[(4-methylpiperazin-1-yl)methyl]-4-oxo-4H-chromen-3-yl}oxy)benzoate
CAS 847336-89-4C25H28N2O6
Propyl 4-{[7-hydroxy-8-[(4-methylpiperazino)methyl]-4-oxo-2-(trifluoromethyl)-4H-chromen-3-yl]oxy}benzoate chemical structure, C26H27F3N2O6, CAS 848689-69-0
Propyl 4-{[7-hydroxy-8-[(4-methylpiperazino)methyl]-4-oxo-2-(trifluoromethyl)-4H-chromen-3-yl]oxy}benzoate
CAS 848689-69-0C26H27F3N2O6
Propyl 4-({8-[(4-ethylpiperazin-1-yl)methyl]-7-hydroxy-4-oxo-4H-chromen-3-yl}oxy)benzoate chemical structure, C26H30N2O6, CAS 845628-27-5
Propyl 4-({8-[(4-ethylpiperazin-1-yl)methyl]-7-hydroxy-4-oxo-4H-chromen-3-yl}oxy)benzoate
CAS 845628-27-5C26H30N2O6
Methyl 4-[(7-hydroxy-8-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}-4-oxo-4H-chromen-3-yl)oxy]benzoate chemical structure, C24H26N2O7, CAS 847380-45-4
Methyl 4-[(7-hydroxy-8-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}-4-oxo-4H-chromen-3-yl)oxy]benzoate
CAS 847380-45-4C24H26N2O7
7-Hydroxy-3-(3-methoxyphenoxy)-2-methyl-8-[(4-methylpiperazin-1-yl)methyl]-4H-chromen-4-one chemical structure, C23H26N2O5, CAS 847182-74-5
7-Hydroxy-3-(3-methoxyphenoxy)-2-methyl-8-[(4-methylpiperazin-1-yl)methyl]-4H-chromen-4-one
CAS 847182-74-5C23H26N2O5
Propyl 4-((7-hydroxy-8-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)-2-methyl-4-oxo-4H-chromen-3-yl)oxy)benzoate chemical structure, C27H32N2O7, CAS 724741-03-1
Propyl 4-((7-hydroxy-8-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)-2-methyl-4-oxo-4H-chromen-3-yl)oxy)benzoate
CAS 724741-03-1C27H32N2O7
7-Hydroxy-3-(4-methoxyphenoxy)-2-methyl-8-((4-methylpiperazin-1-yl)methyl)-4H-chromen-4-one chemical structure, C23H26N2O5, CAS 845900-26-7
7-Hydroxy-3-(4-methoxyphenoxy)-2-methyl-8-((4-methylpiperazin-1-yl)methyl)-4H-chromen-4-one
CAS 845900-26-7C23H26N2O5
7-Hydroxy-8-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}-3-(3-methoxyphenoxy)-2-methyl-4H-chromen-4-one chemical structure, C24H28N2O6, CAS 844836-00-6
7-Hydroxy-8-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}-3-(3-methoxyphenoxy)-2-methyl-4H-chromen-4-one
CAS 844836-00-6C24H28N2O6
Propyl 4-({7-hydroxy-2-methyl-8-[(4-methylpiperazin-1-yl)methyl]-4-oxo-4H-chromen-3-yl}oxy)benzoate chemical structure, C26H30N2O6, CAS 724741-05-3
Propyl 4-({7-hydroxy-2-methyl-8-[(4-methylpiperazin-1-yl)methyl]-4-oxo-4H-chromen-3-yl}oxy)benzoate
CAS 724741-05-3C26H30N2O6
Propyl 4-[(7-hydroxy-8-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}-4-oxo-4H-chromen-3-yl)oxy]benzoate chemical structure, C26H30N2O7, CAS 845899-56-1
Propyl 4-[(7-hydroxy-8-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}-4-oxo-4H-chromen-3-yl)oxy]benzoate
CAS 845899-56-1C26H30N2O7
7-Hydroxy-8-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)-3-(3-methoxyphenoxy)-2-(trifluoromethyl)-4H-chromen-4-one chemical structure, C24H25F3N2O6, CAS 848214-35-7
7-Hydroxy-8-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)-3-(3-methoxyphenoxy)-2-(trifluoromethyl)-4H-chromen-4-one
CAS 848214-35-7C24H25F3N2O6
Ethyl 4-[(7-hydroxy-8-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}-2-methyl-4-oxo-4H-chromen-3-yl)oxy]benzoate chemical structure, C26H30N2O7, CAS 846062-46-2
Ethyl 4-[(7-hydroxy-8-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}-2-methyl-4-oxo-4H-chromen-3-yl)oxy]benzoate
CAS 846062-46-2C26H30N2O7
7-Hydroxy-8-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)-3-(4-methoxyphenoxy)-2-methyl-4H-chromen-4-one chemical structure, C24H28N2O6, CAS 848212-17-9
7-Hydroxy-8-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)-3-(4-methoxyphenoxy)-2-methyl-4H-chromen-4-one
CAS 848212-17-9C24H28N2O6
3-(2-Bromophenoxy)-8-((4-ethylpiperazin-1-yl)methyl)-7-hydroxy-4H-chromen-4-one chemical structure, C22H23BrN2O4, CAS 845800-94-4
3-(2-Bromophenoxy)-8-((4-ethylpiperazin-1-yl)methyl)-7-hydroxy-4H-chromen-4-one
CAS 845800-94-4C22H23BrN2O4
Methyl 4-({8-[(4-ethylpiperazin-1-yl)methyl]-7-hydroxy-2-methyl-4-oxo-4H-chromen-3-yl}oxy)benzoate chemical structure, C25H28N2O6, CAS 845805-54-1
Methyl 4-({8-[(4-ethylpiperazin-1-yl)methyl]-7-hydroxy-2-methyl-4-oxo-4H-chromen-3-yl}oxy)benzoate
CAS 845805-54-1C25H28N2O6