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Murcko scaffold

(4-Phenylpiperazin-1-yl)-quinolin-2-ylmethanone scaffold

8 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
24
Chemicals
8
With full pages
2
Scaffold SMILES

O=C(c1ccc2ccccc2n1)N1CCN(c2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the (4-Phenylpiperazin-1-yl)-quinolin-2-ylmethanone page
Murcko scaffold O=C(c1ccc2ccccc2n1)N1CCN(c2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 8 of 8 chemicals

[4-(4-Methoxyphenyl)piperazin-1-yl]-quinolin-2-ylmethanone chemical structure, C21H21N3O2, CAS 667868-50-0
[4-(4-Methoxyphenyl)piperazin-1-yl]-quinolin-2-ylmethanone
CAS 667868-50-0C21H21N3O2
(4-Phenylpiperazin-1-yl)-quinolin-2-ylmethanone chemical structure, C20H19N3O, CAS 473254-23-8
(4-Phenylpiperazin-1-yl)-quinolin-2-ylmethanone
CAS 473254-23-8C20H19N3O
4,6-Dimethoxy-2-(4-phenylpiperazine-1-carbonyl)quinoline chemical structure, C22H23N3O3, CAS 2415568-70-4
4,6-Dimethoxy-2-(4-phenylpiperazine-1-carbonyl)quinoline
CAS 2415568-70-4C22H23N3O3
2-[4-(4-Fluorophenyl)piperazine-1-carbonyl]-4,6-dimethoxyquinoline chemical structure, C22H22FN3O3, CAS 2415464-09-2
2-[4-(4-Fluorophenyl)piperazine-1-carbonyl]-4,6-dimethoxyquinoline
CAS 2415464-09-2C22H22FN3O3
2-[4-(2-Fluorophenyl)piperazine-1-carbonyl]-4,6-dimethoxyquinoline chemical structure, C22H22FN3O3, CAS 2415620-72-1
2-[4-(2-Fluorophenyl)piperazine-1-carbonyl]-4,6-dimethoxyquinoline
CAS 2415620-72-1C22H22FN3O3
4,6-Dimethoxy-2-[4-(3-methoxyphenyl)piperazine-1-carbonyl]quinoline chemical structure, C23H25N3O4, CAS 2415533-68-3
4,6-Dimethoxy-2-[4-(3-methoxyphenyl)piperazine-1-carbonyl]quinoline
CAS 2415533-68-3C23H25N3O4
4-Ethoxy-6,7-dimethoxy-2-(4-phenylpiperazine-1-carbonyl)quinoline chemical structure, C24H27N3O4, CAS 2415453-30-2
4-Ethoxy-6,7-dimethoxy-2-(4-phenylpiperazine-1-carbonyl)quinoline
CAS 2415453-30-2C24H27N3O4
4-Ethoxy-8-fluoro-2-(4-phenylpiperazine-1-carbonyl)quinoline chemical structure, C22H22FN3O2, CAS 2415602-73-0
4-Ethoxy-8-fluoro-2-(4-phenylpiperazine-1-carbonyl)quinoline
CAS 2415602-73-0C22H22FN3O2